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  1. Content type: Research article

    Multipotent stem cells have been successfully isolated from various tissues and are currently utilized for tissue-engineering and cell-based therapies. Among the many sources, skin has recently emerged as an a...

    Authors: Radhakrishnan Vishnubalaji, Muthurangan Manikandan, May Al-Nbaheen, Balamuthu Kadalmani, Abdullah Aldahmash and Nehad M Alajez

    Citation: BMC Developmental Biology 2012 12:7

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  2. Content type: Research article

    Because of the structural and molecular similarities between the two systems, the lateral line, a fish and amphibian specific sensory organ, has been widely used in zebrafish as a model to study the developmen...

    Authors: Martine Behra, Viviana E Gallardo, John Bradsher, Aranza Torrado, Abdel Elkahloun, Jennifer Idol, Jessica Sheehy, Seth Zonies, Lisha Xu, Kenna M Shaw, Chie Satou, Shin-ichi Higashijima, Brant M Weinstein and Shawn M Burgess

    Citation: BMC Developmental Biology 2012 12:6

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  3. Content type: Research article

    Multicellularity in cellular slime molds is achieved by aggregation of several hundreds to thousands of cells. In the model slime mold Dictyostelium discoideum, adenosine is known to increase the aggregate size a...

    Authors: Pundrik Jaiswal, Thierry Soldati, Sascha Thewes and Ramamurthy Baskar

    Citation: BMC Developmental Biology 2012 12:5

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  4. Content type: Research article

    Germline stem cells (GSCs) are present in the gonads of Drosophila females and males, and their proper maintenance, as well as their correct differentiation, is essential for fertility and fecundity. The molec...

    Authors: Amy C Cash and Justen Andrews

    Citation: BMC Developmental Biology 2012 12:4

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  5. Content type: Research article

    Cell adhesion, an integral part of D. discoideum development, is important for morphogenesis and regulated gene expression in the multicellular context and is required to trigger cell-differentiation. G-protein l...

    Authors: Hameeda Sultana, Girish Neelakanta, Francisco Rivero, Rosemarie Blau-Wasser, Michael Schleicher and Angelika A Noegel

    Citation: BMC Developmental Biology 2012 12:3

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  6. Content type: Research article

    The desmosomal cadherins (DCs), desmocollin (Dsc) and desmoglein (Dsg), are the adhesion molecules of desmosomes, intercellular adhesive junctions of epithelia and cardiac muscle. Both the DCs and desmosomes h...

    Authors: Alexander Goonesinghe, Xing-Ming Luan, Adam Hurlstone and David Garrod

    Citation: BMC Developmental Biology 2012 12:1

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    The Erratum to this article has been published in BMC Developmental Biology 2014 14:13

  7. Content type: Research article

    Kangaroos and wallabies have specialised limbs that allow for their hopping mode of locomotion. The hindlimbs differentiate much later in development but become much larger than the forelimbs. The hindlimb aut...

    Authors: Keng Yih Chew, Hongshi Yu, Andrew J Pask, Geoffrey Shaw and Marilyn B Renfree

    Citation: BMC Developmental Biology 2012 12:2

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  8. Content type: Methodology article

    Hemangioblasts are known as the common precursors for primitive hematopoietic and endothelial lineages. Their existence has been supported mainly by the observation that both cell types develop in close proxim...

    Authors: Vera Teixeira, Natacha Arede, Rui Gardner, Joaquín Rodríguez-León and Ana T Tavares

    Citation: BMC Developmental Biology 2011 11:76

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  9. Content type: Research article

    The lung and thyroid are derived from the anterior endoderm. Retinoic acid and Fgf signalling are known to be essential for development of the lung in mouse but little is known on how the lung and thyroid are ...

    Authors: Jean H Wang, Steven J Deimling, Nicole E D'Alessandro, Lin Zhao, Fred Possmayer and Thomas A Drysdale

    Citation: BMC Developmental Biology 2011 11:75

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  10. Content type: Research article

    The molecular mechanism that initiates the formation of the vertebrate central nervous system has long been debated. Studies in Xenopus and mouse demonstrate that inhibition of BMP signaling is sufficient to indu...

    Authors: Crystal D Rogers, George S Ferzli and Elena S Casey

    Citation: BMC Developmental Biology 2011 11:74

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  11. Content type: Research article

    Desert hedgehog (DHH) belongs to the hedgehog gene family that act as secreted intercellular signal transducers. DHH is an essential morphogen for normal testicular development and function in both mice and human...

    Authors: William A O'Hara, Walid J Azar, Richard R Behringer, Marilyn B Renfree and Andrew J Pask

    Citation: BMC Developmental Biology 2011 11:72

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  12. Content type: Research article

    Genetic alterations in human topoisomerase II alpha (TOP2A) are linked to cancer susceptibility. TOP2A decatenates chromosomes and thus is necessary for multiple aspects of cell division including DNA replication...

    Authors: Beata Sapetto-Rebow, Sarah C McLoughlin, Lynne C O'Shea, Olivia O'Leary, Jason R Willer, Yolanda Alvarez, Ross Collery, Jacintha O'Sullivan, Freek Van Eeden, Carmel Hensey and Breandán N Kennedy

    Citation: BMC Developmental Biology 2011 11:71

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  13. Content type: Research article

    The molecular mechanisms governing vertebrate appendage regeneration remain poorly understood. Uncovering these mechanisms may lead to novel therapies aimed at alleviating human disfigurement and visible loss ...

    Authors: Nick R Love, Yaoyao Chen, Boyan Bonev, Michael J Gilchrist, Lynne Fairclough, Robert Lea, Timothy J Mohun, Roberto Paredes, Leo AH Zeef and Enrique Amaya

    Citation: BMC Developmental Biology 2011 11:70

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  14. Content type: Research article

    The freshwater planarian Schmidtea mediterranea exhibits two distinct reproductive modes. Individuals of the sexual strain are cross-fertilizing hermaphrodites with reproductive organs that develop post-embryonic...

    Authors: Tracy Chong, Joel M Stary, Yuying Wang and Phillip A Newmark

    Citation: BMC Developmental Biology 2011 11:69

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  15. Content type: Research article

    Neural crest cells (NCCs) are embryonic, multipotent stem cells. Their long-range and precision-guided migration is one of their most striking characteristics. We previously reported that P0-Cre/CAG-CAT-lacZ doub...

    Authors: Minoru Kawakami, Masafumi Umeda, Naomi Nakagata, Toru Takeo and Ken-ichi Yamamura

    Citation: BMC Developmental Biology 2011 11:68

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  16. Content type: Research article

    Progesterone triggers resumption of the first meiotic division in the Rana pipiens oocyte by binding to the N-terminal external loop of the catalytic subunit of Na/K-ATPase, releasing a cascade of lipid second me...

    Authors: Gene A Morrill, Terry L Dowd, Adele B Kostellow and Raj K Gupta

    Citation: BMC Developmental Biology 2011 11:67

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  17. Content type: Research article

    During Drosophila development, titers of the steroid ecdysone trigger and maintain temporal and tissue specific biological transitions. Decades of evidence reveal that the ecdysone response is both unique to spec...

    Authors: Melissa B Davis, Inigo SanGil, Grace Berry, Rashidat Olayokun and Lori H Neves

    Citation: BMC Developmental Biology 2011 11:66

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  18. Content type: Research article

    The T-box transcription factor TBX3 is necessary for early embryonic development and for the normal development of the mammary gland. Homozygous mutations, in mice, are embryonic lethal while heterozygous muta...

    Authors: Jing Liu, Taraneh Esmailpour, Xiying Shang, Gultekin Gulsen, Andy Liu and Taosheng Huang

    Citation: BMC Developmental Biology 2011 11:65

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  19. Content type: Research article

    Identifying DNA sequences (enhancers) that direct the precise spatial and temporal expression of developmental control genes remains a significant challenge in the annotation of vertebrate genomes. Locating th...

    Authors: Sumantra Chatterjee, Guillaume Bourque and Thomas Lufkin

    Citation: BMC Developmental Biology 2011 11:63

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  20. Content type: Research article

    We recently identified Rbm24 as a novel gene expressed during mouse cardiac development. Due to its tightly restricted and persistent expression from formation of the cardiac crescent onwards and later in forming...

    Authors: Samantha Maragh, Ronald A Miller, Seneca L Bessling, David M McGaughey, Marja W Wessels, Bianca de Graaf, Eric A Stone, Aida M Bertoli-Avella, John D Gearhart, Shannon Fisher and Andrew S McCallion

    Citation: BMC Developmental Biology 2011 11:62

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  21. Content type: Research article

    Determining the type and source of cells involved in regenerative processes has been one of the most important goals of researchers in the field of regeneration biology. We have previously used several cellula...

    Authors: José E García-Arrarás, Griselle Valentín-Tirado, Jaime E Flores, Rey J Rosa, Angélica Rivera-Cruz, José E San Miguel-Ruiz and Karen Tossas

    Citation: BMC Developmental Biology 2011 11:61

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  22. Content type: Research article

    Valuable insights into the complex process of retinal vascular development can be gained using models with abnormal retinal vasculature. Two such models are the recently described mouse lines with mutations in La...

    Authors: Malia M Edwards, D Scott McLeod, Rhonda Grebe, Céline Heng, Olivier Lefebvre and Gerard A Lutty

    Citation: BMC Developmental Biology 2011 11:60

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  23. Content type: Research article

    Sox6 is a multi-faceted transcription factor involved in the terminal differentiation of many different cell types in vertebrates. It has been suggested that in mice as well as in zebrafish Sox6 plays a role i...

    Authors: Chung-Il An, Yao Dong and Nobuko Hagiwara

    Citation: BMC Developmental Biology 2011 11:59

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  24. Content type: Research article

    TG-interacting factors (TGIFs) belong to a family of TALE-homeodomain proteins including TGIF1, TGIF2 and TGIFLX/Y in human. Both TGIF1 and TGIF2 act as transcription factors repressing TGF-β signalling. Human TG...

    Authors: Yanqiu Hu, Hongshi Yu, Geoff Shaw, Marilyn B Renfree and Andrew J Pask

    Citation: BMC Developmental Biology 2011 11:58

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  25. Content type: Research article

    Epithelial neoplasias are associated with alterations in cell polarity and excessive cell proliferation, yet how these neoplastic properties are related to one another is still poorly understood. The study of Dro...

    Authors: Karen Doggett, Felix A Grusche, Helena E Richardson and Anthony M Brumby

    Citation: BMC Developmental Biology 2011 11:57

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  26. Content type: Research article

    During liver development, intrahepatic bile ducts are thought to arise by a unique asymmetric mode of cholangiocyte tubulogenesis characterized by a series of remodeling stages. Moreover, in liver diseases, ce...

    Authors: Peter S Vestentoft, Peter Jelnes, Branden M Hopkinson, Ben Vainer, Kjeld Møllgård, Bjørn Quistorff and Hanne C Bisgaard

    Citation: BMC Developmental Biology 2011 11:56

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  27. Content type: Methodology article

    Rapid advances in genomics have provided nearly complete genome sequences for many different species. However, no matter how the sequencing technology has improved, natural genetic polymorphism complicates the...

    Authors: Irene E Samonte-Padilla, Christophe Eizaguirre, Jörn P Scharsack, Tobias L Lenz and Manfred Milinski

    Citation: BMC Developmental Biology 2011 11:55

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  28. Content type: Research article

    Surgical removal of the lens from larval Xenopus laevis results in a rapid transdifferention of central corneal cells to form a new lens. The trigger for this process is understood to be an induction event arisin...

    Authors: Robert C Day and Caroline W Beck

    Citation: BMC Developmental Biology 2011 11:54

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  29. Content type: Research article

    Nkx2.2 and Arx represent key transcription factors implicated in the specification of islet cell subtypes during pancreas development. Mice deficient for Arx do not develop any alpha-cells whereas beta- and delta...

    Authors: Simon Kordowich, Patrick Collombat, Ahmed Mansouri and Palle Serup

    Citation: BMC Developmental Biology 2011 11:52

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  30. Content type: Research article

    Retinoic acid (RA) is important for vertebrate eye morphogenesis and is a regulator of photoreceptor development in the retina. In the zebrafish, RA treatment of postmitotic photoreceptor precursors has been s...

    Authors: Craig B Stevens, David A Cameron and Deborah L Stenkamp

    Citation: BMC Developmental Biology 2011 11:51

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  31. Content type: Research article

    We recently identified a novel oncogene, Cancer-upregulated gene 2 (CUG2), which is essential for kinetochore formation and promotes tumorigenesis in mammalian cells. However, the in vivo function of CUG2 has ...

    Authors: Hyun-Taek Kim, Ju-Hoon So, Seung-Hyun Jung, Dae-Gwon Ahn, Wansoo Koh, Nam-Soon Kim, Soo-Hyun Kim, Soojin Lee and Cheol-Hee Kim

    Citation: BMC Developmental Biology 2011 11:49

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  32. Content type: Research article

    Despite the detailed knowledge obtained over the last decade on the molecular regulation of gastrulation in amniotes, the process of amnion development has been poorly described and illustrated in mice, and co...

    Authors: Paulo NG Pereira, Mariya P Dobreva, Liz Graham, Danny Huylebroeck, Kirstie A Lawson and AN Zwijsen

    Citation: BMC Developmental Biology 2011 11:48

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  33. Content type: Research article

    The development of vertebrate limbs has been a traditional system to study fundamental processes at work during ontogenesis, such as the establishment of spatial cellular coordinates, the effect of diffusible ...

    Authors: Istvan Gyurján, Bernhard Sonderegger, Felix Naef and Denis Duboule

    Citation: BMC Developmental Biology 2011 11:47

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  34. Content type: Research article

    Understanding the mechanisms governing cell fate specification remains one of the main challenges in the study of retinal development. In this context, molecular markers that identify specific cell types becom...

    Authors: Christian Gutierrez, Minda McNally and M Valeria Canto-Soler

    Citation: BMC Developmental Biology 2011 11:46

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  35. Content type: Research article

    In a recent genomic study, Leung et al. used a factorial microarray analysis to identify Smarca4 (Brg1)-regulated genes in micro-dissected zebrafish retinas. Two hundred and fifty nine genes were grouped in th...

    Authors: Monica R Hensley, Farida Emran, Sylvia Bonilla, Liyun Zhang, Wenxuan Zhong, Paul Grosu, John E Dowling and Yuk Fai Leung

    Citation: BMC Developmental Biology 2011 11:45

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  36. Content type: Research article

    In vitro studies using the myogenic cell line C2C12 demonstrate that bone morphogenetic protein-2 (BMP-2) converts the developmental pathway of C2C12 from a myogenic cell lineage to an osteoblastic cell lineag...

    Authors: Kayoko Aoyama, Akira Yamane, Takeo Suga, Erika Suzuki, Tadayoshi Fukui and Yoshiki Nakamura

    Citation: BMC Developmental Biology 2011 11:44

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  37. Content type: Methodology article

    Whole-mount in situ hybridization (WISH) is extensively used to characterize gene expression patterns in developing and adult brain and other tissues. To obtain an idea whether a novel gene might be involved in s...

    Authors: Gilbert Lauter, Iris Söll and Giselbert Hauptmann

    Citation: BMC Developmental Biology 2011 11:43

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  38. Content type: Research article

    Loss of heterozygosity at 18q, which includes the Deleted in Colorectal Cancer (DCC) gene, has been linked to many human cancers. However, it is unclear if loss of DCC is the specific underlying cause of these ca...

    Authors: Adrienne VanZomeren-Dohm, Joseph Sarro, Ellen Flannery and Molly Duman-Scheel

    Citation: BMC Developmental Biology 2011 11:41

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  39. Content type: Research article

    Heparan sulfate (HS) is present on the surface of virtually all mammalian cells and is a major component of the extracellular matrix (ECM), where it plays a pivotal role in cell-cell and cell-matrix cross-talk...

    Authors: Sophie M Thompson, Marilyn G Connell, Toin H van Kuppevelt, Ruoyan Xu, Jeremy E Turnbull, Paul D Losty, David G Fernig and Edwin C Jesudason

    Citation: BMC Developmental Biology 2011 11:38

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  40. Content type: Research article

    The ERBB3 gene is essential for the proper development of the neural crest (NC) and its derivative populations such as Schwann cells. As with all cell fate decisions, transcriptional regulatory control plays a si...

    Authors: Megana K Prasad, Xylena Reed, David U Gorkin, Julia C Cronin, Anthony R McAdow, Kristopher Chain, Chani J Hodonsky, Erin A Jones, John Svaren, Anthony Antonellis, Stephen L Johnson, Stacie K Loftus, William J Pavan and Andrew S McCallion

    Citation: BMC Developmental Biology 2011 11:40

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  41. Content type: Research article

    Sphingosine-1-phosophate (S1P) is a biologically active sphingolipid metabolite that influences cellular events including differentiation, proliferation, and migration. S1P acts through five distinct cell surf...

    Authors: Ryan R Poulsen, Carolyn M McClaskey, Scott A Rivkees and Christopher C Wendler

    Citation: BMC Developmental Biology 2011 11:37

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  42. Content type: Research article

    Paraxial protocadherin (PAPC) plays a crucial role in morphogenetic movements during gastrulation and somitogenesis in mouse, zebrafish and Xenopus. PAPC influences cell-cell adhesion mediated by C-Cadherin. A...

    Authors: Barbara Jung, Almut Köhler, Alexandra Schambony and Doris Wedlich

    Citation: BMC Developmental Biology 2011 11:36

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  43. Content type: Research article

    Teneurin-1 is a member of a family of type II transmembrane proteins conserved from C.elegans to vertebrates. Teneurin expression in vertebrates is best studied in mouse and chicken, where the four members teneur...

    Authors: Jan Beckmann, Antonio Vitobello, Jacqueline Ferralli, Daniela Kenzelmann Brož, Filippo M Rijli and Ruth Chiquet-Ehrismann

    Citation: BMC Developmental Biology 2011 11:35

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  44. Content type: Research article

    MicroRNAs (miRNAs) are small RNA molecules that post-transcriptionally regulate gene expression and have been shown to play an important role during development. miR-1, miR-133a, miR-133b and miR-206 are expre...

    Authors: Andrie Koutsoulidou, Nikolaos P Mastroyiannopoulos, Denis Furling, James B Uney and Leonidas A Phylactou

    Citation: BMC Developmental Biology 2011 11:34

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