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  • Erratum
  • Open Access

Erratum to: Histamine is a modulator of metamorphic competence in Strongylocentrotus purpuratus (Echinodermata: Echinoidea)

  • 1,
  • 1,
  • 1,
  • 2,
  • 2, 3 and
  • 1Email author
BMC Developmental Biology201313:30

  • Received: 6 June 2013
  • Accepted: 12 June 2013
  • Published:

The original article was published in BMC Developmental Biology 2012 12:14

In Figure six (Figure 1 here) of the original manuscript [1] panels B-H are representative images from which measurements were taken and then graphed in Figure six panel I. In the original submission of the manuscript panel C and H ended up showing identical images. We corrected this error by replacing panel C with the correct representative image. Note that this error occurred when preparing the original figure and it does not affect the data presented in any way.
Figure 1
Figure 1

Histamine (HA) receptor 1 antagonist (125 μM chlorpheniramine) and histidine decarboxylase (HDC) inhibitor alpha-methylhistidine (AMH, 100 μM) treatment of competent larvae leads to increased caspase activity. Caspase activity was analyzed using FAM-VAD-FMK, a fluorescently tagged caspase inhibitor. Normalized fluorescence was measured in the arm tips of competent larvae. HA, HA receptor 2 antagonist (200 μM cimetidine), HA receptor 3 antagonist (125 μM Thioperamide) and KCl had no effect on caspase activity. The upper panel shows representative fluorescent images of treatment categories: B-control, C-HA (1 μM), D- HA receptor 1 antagonist (125 μM chlorpheniramine), E-HA receptor 2 antagonist (200 μM cimetidine), F-HA receptor 3 antagonist (125 μM Thioperamide), G-alpha-methylhistidine (AMH, 100 μM) and H-KCl. The lower panel shows the corresponding results of the fluorescent analysis. Panel A illustrates the approximate region of the arms that was included in the analysis. Note that all fluorescent intensities were normalized to the area measured and the exposure time. Scale bars: 20 μm.



Authors’ Affiliations

University of Guelph, Integrative Biology, Guelph, ON, N1G-2 W1, Canada
Brown University, MCB, Providence, RI 02912, USA
Present address: U.S. Naval Medical Research Unit No.6, Lima, Peru


  1. Sutherby J, Giardini JL, Nguyen J, Wessel G, Leguia M, Heyland A: Histamine is a modulator of metamorphic competence in Strongylocentrotus purpuratus (Echinodermata: Echinoidea). BMC Dev Biol. 2012, 12: 14-10.1186/1471-213X-12-14.PubMed CentralView ArticlePubMedGoogle Scholar


© Sutherby et al.; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.