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  1. Content type: Research article

    Integrins are transmembrane receptors that mediate cell–extracellular matrix (ECM) and cell-cell adhesion and trophoblast cells undergo changes in integrin expression as they differentiate. However, the mechan...

    Authors: Eiko Kawamura, Gina B. Hamilton, Ewa I. Miskiewicz and Daniel J. MacPhee

    Citation: BMC Developmental Biology 2018 18:19

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  2. Content type: Research article

    Mammalian brain is formed through neural tube closure (NTC), wherein both ridges of opposing neural folds are fused in the midline and remodeled in the roof plate of the neural tube and overlying non-neural ec...

    Authors: Naomi Shinotsuka, Yoshifumi Yamaguchi, Kenichi Nakazato, Yudai Matsumoto, Atsushi Mochizuki and Masayuki Miura

    Citation: BMC Developmental Biology 2018 18:17

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  3. Content type: Research article

    Alterations in maternal environment can sometimes affect embryonic development in a sexually-dimorphic manner. The objective was to determine whether preimplantation bovine embryos respond to three maternally-...

    Authors: Paula Tríbulo, Gulnur Jumatayeva, Khoboso Lehloenya, James I. Moss, Veronica M. Negrón-Pérez and Peter J. Hansen

    Citation: BMC Developmental Biology 2018 18:16

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  4. Content type: Research article

    Diabetes and hypothyroidism produce adverse effects on body weight and sexual maturity by inhibiting body growth and metabolism. The occurrence of diabetes is always accompanied with thyroid dysfunction. Thus,...

    Authors: Nazar Ali KOREJO, Quanwei WEI, Kaizhi ZHENG, Dagan MAO, Rashid Ali KOREJO, Atta Hussain SHAH and Fangxiong SHI

    Citation: BMC Developmental Biology 2018 18:15

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  5. Content type: Research article

    Dmrt2a is a zinc finger like transcription factor with several roles during zebrafish early development: left-right asymmetry, synchronisation of the somite clock genes and fast muscle differentiation. Despite...

    Authors: Rita Alexandra Pinto, José Almeida-Santos, Raquel Lourenço and Leonor Saúde

    Citation: BMC Developmental Biology 2018 18:14

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  6. Content type: Research article

    Pregnant women may be exposed to nicotine if they smoke or use tobacco products, nicotine replacement therapy, or via e-cigarettes. Prenatal nicotine exposure has been shown to have deleterious effects on the ...

    Authors: Melanie Morris, Ariel Shaw, Madison Lambert, Haley Halperin Perry, Eve Lowenstein, David Valenzuela and Norma Andrea Velazquez-Ulloa

    Citation: BMC Developmental Biology 2018 18:13

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  7. Content type: Research article

    The proliferating cell nuclear antigen (PCNA or PCN-1 in C. elegans), an essential processivity factor for DNA polymerase δ, has been widely used as a marker of S-phase. In C. elegans early embryos, PCN-1 accumul...

    Authors: Zuzana Kocsisova, Kerry Kornfeld and Tim Schedl

    Citation: BMC Developmental Biology 2018 18:12

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  8. Content type: Research article

    Honeybee development consists of four stages: embryo, larva, pupa and adult. Embryogenesis, a key process of cell division and differentiation, takes 3 days in honeybees. However, the embryonic transcriptome a...

    Authors: Xiaofen Hu, Li Ke, Zilong Wang and Zhijiang Zeng

    Citation: BMC Developmental Biology 2018 18:11

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  9. Content type: Research article

    Male European seabass, already predominant (~ 70%) in cultured stocks, show a high incidence (20–30%) of precocious sexual maturation under current aquaculture practices, leading to important economic losses f...

    Authors: Marco Graziano, Raul Benito, Josep V. Planas and Arjan P. Palstra

    Citation: BMC Developmental Biology 2018 18:10

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  10. Content type: Research article

    In this work we have determined molecular signatures of oviduct epithelial and progenitor cells. We have proposed a panel of selected marker genes, which correspond with the phenotype of oviduct cells of a lay...

    Authors: Katarzyna Stadnicka, Anna Sławińska, Aleksandra Dunisławska, Bertrand Pain and Marek Bednarczyk

    Citation: BMC Developmental Biology 2018 18:9

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  11. Content type: Research article

    The experimental approach to the evolution and development of the vertebrate skeleton has to a large extent relied on “direct-developing” amniote model organisms, such as the mouse and the chicken. These organ...

    Authors: Joost M. Woltering, Michaela Holzem, Ralf F. Schneider, Vasilios Nanos and Axel Meyer

    Citation: BMC Developmental Biology 2018 18:8

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  12. Content type: Review

    FK506-binding proteins (FKBPs) have become the subject of considerable interest in several fields, leading to the identification of several cellular and molecular pathways in which FKBPs impact prenatal develo...

    Authors: George Ghartey-Kwansah, Zhongguang Li, Rui Feng, Liyang Wang, Xin Zhou, Frederic Z. Chen, Meng Meng Xu, Odell Jones, Yulian Mu, Shawn Chen, Joseph Bryant, Williams B. Isaacs, Jianjie Ma and Xuehong Xu

    Citation: BMC Developmental Biology 2018 18:7

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  13. Content type: Research article

    Tbx5 deficiency in zebrafish causes several abnormal phenotypes of the heart and pectoral fins. It has been reported that exogenous human growth hormone can enhance expression of downstream mediators in the growt...

    Authors: Tzu-Chun Tsai, Chun-Che Shih, Hsin-Ping Chien, An-Hang Yang, Jenn-Kan Lu and Jen-Her Lu

    Citation: BMC Developmental Biology 2018 18:5

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  14. Content type: Research article

    Germ cell formation has been investigated in sessile forms of tunicates. This process involves the release of a subset of maternal transcripts from the centrosome-attracting body (CAB) in the progenitor cells ...

    Authors: Lisbeth Charlotte Olsen, Ioannis Kourtesis, Henriette Busengdal, Marit Flo Jensen, Harald Hausen and Daniel Chourrout

    Citation: BMC Developmental Biology 2018 18:4

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  15. Content type: Research article

    MiR-9 is a small non-coding RNA that is highly conserved between species and primarily expressed in the central nervous system (CNS). It is known to influence proliferation and neuronal differentiation in the ...

    Authors: A. Alwin Prem Anand, Carola Huber, John Asnet Mary, Nancy Gallus, Christoph Leucht, Ruth Klafke, Bernhard Hirt and Andrea Wizenmann

    Citation: BMC Developmental Biology 2018 18:3

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  16. Content type: Research article

    The compound eyes of insects allow them to catch photons and convert the energy into electric signals. All compound eyes consist of numerous ommatidia, each comprising a fixed number of photoreceptors. Differe...

    Authors: Leonie Lichtenstein, Kornelia Grübel and Johannes Spaethe

    Citation: BMC Developmental Biology 2018 18:1

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  17. Content type: Research article

    All animals have mechanisms for healing damage to the epithelial sheets that cover the body and line internal cavities. Epithelial wounds heal either by cells crawling over the wound gap, by contraction of a s...

    Authors: Zach Kamran, Katie Zellner, Harry Kyriazes, Christine M. Kraus, Jean-Baptiste Reynier and Jocelyn E. Malamy

    Citation: BMC Developmental Biology 2017 17:17

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  18. Content type: Research article

    Over one third of all animal phyla utilize a mode of early embryogenesis called ‘spiral cleavage’ to divide the fertilized egg into embryonic cells with different cell fates. This mode is characterized by a se...

    Authors: Aron B. Nakama, Hsien-Chao Chou and Stephan Q. Schneider

    Citation: BMC Developmental Biology 2017 17:16

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  19. Content type: Methodology article

    The Midas cichlid species complex (Amphilophus spp.) is widely known among evolutionary biologists as a model system for sympatric speciation and adaptive phenotypic divergence within extremely short periods of t...

    Authors: Claudius F. Kratochwil, Maggie M. Sefton, Yipeng Liang and Axel Meyer

    Citation: BMC Developmental Biology 2017 17:15

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  20. Content type: Research article

    The Runt-related transcription factors (Runx) are a family of evolutionarily conserved transcriptional regulators that play multiple roles in the developmental control of various cell types. Among the three ma...

    Authors: Sebastian Nieke, Nighat Yasmin, Kiyokazu Kakugawa, Tomomasa Yokomizo, Sawako Muroi and Ichiro Taniuchi

    Citation: BMC Developmental Biology 2017 17:14

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  21. Content type: Research article

    Vertebrate head development depends on a series of interactions between many cell populations of distinct embryological origins. Cranial mesenchymal tissues have a dual embryonic source: - the neural crest (NC...

    Authors: Barbara F. Fonseca, Gérard Couly and Elisabeth Dupin

    Citation: BMC Developmental Biology 2017 17:13

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  22. Content type: Research article

    The quality and yield of duck feathers are very important economic traits that might be controlled by miRNA regulation. The aim of the present study was to investigate the mechanism underlying the crosstalk be...

    Authors: Xingyong Chen, Kai Ge, Min Wang, Cheng Zhang and Zhaoyu Geng

    Citation: BMC Developmental Biology 2017 17:12

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  23. Content type: Research article

    The identification of DNA methyltransferases (Dnmt) expression patterns during development and their regulation is important to understand the epigenetic mechanisms that modulate larval plasticity in marine fi...

    Authors: Joana Firmino, Carlos Carballo, Paula Armesto, Marco A. Campinho, Deborah M. Power and Manuel Manchado

    Citation: BMC Developmental Biology 2017 17:11

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  24. Content type: Research article

    Cathepsin B is a lysosomal cysteine protease involved in apoptosis and oocytes which have lower developmental competence show higher expression of Cathepsin B. Furthermore, expression of Cathepsin B show a dec...

    Authors: M. Pezhman, S. M. Hosseini, S. Ostadhosseini, Sh. Rouhollahi Varnosfaderani, F. Sefid and M. H. Nasr-Esfahani

    Citation: BMC Developmental Biology 2017 17:10

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  25. Content type: Research article

    Mitochondrial alternative respiratory-chain enzymes are phylogenetically widespread, and buffer stresses affecting oxidative phosphorylation in species that possess them. However, they have been lost in the ev...

    Authors: Sina Saari, Ana Andjelković, Geovana S. Garcia, Howard T. Jacobs and Marcos T. Oliveira

    Citation: BMC Developmental Biology 2017 17:9

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  26. Content type: Research article

    The tauGFP reporter fusion protein is produced nearly ubiquitously by the TgTP6.3 transgene in TP6.3 mice and its localisation to microtubules offers some advantages over soluble GFP as a lineage marker. However,...

    Authors: Linda Sharp, Thomas Pratt, Gillian E. MacKay, Margaret A. Keighren, Jean H. Flockhart, Emma J. Chandler, David J. Price, John O. Mason and John D. West

    Citation: BMC Developmental Biology 2017 17:8

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  27. Content type: Research article

    Loss of proprotein convertase subtilisin/kexin type 5 (Pcsk5) results in multiple developmental anomalies including cardiac malformations, caudal regression, pre-sacral mass, renal agenesis, anteroposterior patte...

    Authors: Dorota Szumska, Milena Cioroch, Angela Keeling, Annik Prat, Nabil G. Seidah and Shoumo Bhattacharya

    Citation: BMC Developmental Biology 2017 17:6

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  28. Content type: Research article

    Cranial neural crest cells (NCCs) are a unique embryonic cell type which give rise to a diverse array of derivatives extending from neurons and glia through to bone and cartilage. Depending on their point of o...

    Authors: Rachael Lumb, Sam Buckberry, Genevieve Secker, David Lawrence and Quenten Schwarz

    Citation: BMC Developmental Biology 2017 17:5

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  29. Content type: Research article

    The molecular mechanisms underlying the development of the unusual echinoderm pentameral body plan and their likeness to mechanisms underlying the development of the bilateral plans of other deuterostomes are ...

    Authors: Demian Koop, Paula Cisternas, Valerie B. Morris, Dario Strbenac, Jean Yee Hwa Yang, Gregory A. Wray and Maria Byrne

    Citation: BMC Developmental Biology 2017 17:4

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  30. Content type: Research article

    Lake Malawi cichlids represent one of a growing number of vertebrate models used to uncover the genetic and developmental basis of trait diversity. Rapid evolutionary radiation has resulted in species that sha...

    Authors: R. F. Bloomquist, T. E. Fowler, J. B. Sylvester, R. J. Miro and J. T. Streelman

    Citation: BMC Developmental Biology 2017 17:3

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  31. Content type: Research article

    Many parasites regulate their development to synchronize their life cycle with a compatible host. The parasitic nematode Heterodera glycines displays incomplete host-mediated hatching behavior wherein some H. gly...

    Authors: Sita Thapa, Jayna A. Patel, Ursula Reuter-Carlson and Nathan E. Schroeder

    Citation: BMC Developmental Biology 2017 17:2

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  32. Content type: Research article

    Thus far, a handful of genes have been shown to be related to the wing maturation process in insects. A novel heme peroxidase enzyme known as curly suppressor (Cysu)(formerly CG5873), have been characterized i...

    Authors: Dondra Bailey, Mohammed Abul Basar, Sanjay Nag, Nivedita Bondhu, Shaloei Teng and Atanu Duttaroy

    Citation: BMC Developmental Biology 2017 17:1

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  33. Content type: Research article

    An increase in the activity of the pituitary-gonad axis (PG-axis) and gonad development are essential for the onset of spawning migration in teleosts. In the fish Coilia nasus, gonad development and spawning migr...

    Authors: Jin-Rong Duan, Di-An Fang, Min-Ying Zhang, Kai Liu, Yan-Feng Zhou, Dong-Po Xu, Pao Xu and Da-Peng Li

    Citation: BMC Developmental Biology 2016 16:42

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  34. Content type: Research article

    Long non-coding RNAs (LncRNAs) have been identified to play important roles in epigenetic processes that underpin organogenesis. However, the role of LncRNAs in the regulation of transition from fetal to adult...

    Authors: Jue Wang, Zhimin Geng, Jiakan Weng, Longjie Shen, Ming Li, Xueli Cai, Chengchao Sun and Maoping Chu

    Citation: BMC Developmental Biology 2016 16:41

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  35. Content type: Research article

    Establishment of the left-right axis is important for positioning organs asymmetrically in the developing vertebrate-embryo. A number of factors like maternally deposited molecules have emerged essential in in...

    Authors: Kartik Gupta, Vijaya Satish Sekhar Pilli and Gopala Krishna Aradhyam

    Citation: BMC Developmental Biology 2016 16:39

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  36. Content type: Research article

    Because ribosomes are ubiquitously required for protein production, it was long assumed that any inherited defect in ribosome manufacture would be embryonically lethal. However, several human congenital diseas...

    Authors: Andrew Robson, Nick D. L. Owens, Susan J. Baserga, Mustafa K. Khokha and John N. Griffin

    Citation: BMC Developmental Biology 2016 16:38

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  37. Content type: Research article

    Increased apposition of the frontal and parietal bones of the skull during embryogenesis may be a risk factor for the subsequent development of premature skull fusion, or craniosynostosis. Human craniosynostos...

    Authors: Stephen J. Goldie, Benedicta D. Arhatari, Peter Anderson, Alana Auden, Darren D. Partridge, Stephen M. Jane and Sebastian Dworkin

    Citation: BMC Developmental Biology 2016 16:37

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  38. Content type: Research article

    Successful development of iSCNT (interspecies somatic cell nuclear transfer) embryos depends on complex interactions between ooplasmic and nuclear components, which can be compromised by genetic divergence. Tr...

    Authors: L. Antonio González-Grajales, Laura A. Favetta, W. Allan King and Gabriela F. Mastromonaco

    Citation: BMC Developmental Biology 2016 16:36

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  39. Content type: Research article

    The multicellular volvocine alga Pleodorina is intermediate in organismal complexity between its unicellular relative, Chlamydomonas, and its multicellular relative, Volvox, which shows complete division of labor...

    Authors: Stephanie Höhn and Armin Hallmann

    Citation: BMC Developmental Biology 2016 16:35

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  40. Content type: Research article

    Bone morphogenetic protein (BMP) signalling has emerged as a fundamental pathway in endothelial cell biology and deregulation of this pathway is implicated in several vascular disorders. BMP signalling output ...

    Authors: Karen Beets, Michael W. Staring, Nathan Criem, Elke Maas, Niels Schellinx, Susana M. Chuva de Sousa Lopes, Lieve Umans and An Zwijsen

    Citation: BMC Developmental Biology 2016 16:34

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  41. Content type: Research article

    Nuclear receptors are a highly conserved set of ligand binding transcription factors, with essential roles regulating aspects of vertebrate and invertebrate biology alike. Current understanding of nuclear rece...

    Authors: Susanne Vogeler, Tim P. Bean, Brett P. Lyons and Tamara S. Galloway

    Citation: BMC Developmental Biology 2016 16:33

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  42. Content type: Methodology article

    Nuclear Factor-Kappa B (NF-kB) is a family of transcription factors that are important in embryonic development, inflammation, epithelial-to-mesenchymal transition and cancer. The 65 kDa RelA subunit is the ma...

    Authors: Talha Ijaz, Maki Wakamiya, Hong Sun, Adrian Recinos III, Ronald G. Tilton and Allan R. Brasier

    Citation: BMC Developmental Biology 2016 16:32

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  43. Content type: Research article

    HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 (HACE1) regulates a wide variety of cellular processes. It has been shown that one of the targets of HACE1 is the GTP-bound form of the s...

    Authors: Akira Iimura, Fuhito Yamazaki, Toshiyasu Suzuki, Tatsuya Endo, Eisuke Nishida and Morioh Kusakabe

    Citation: BMC Developmental Biology 2016 16:31

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  44. Content type: Research article

    Wnt11 is a member of the Wnt family of secreted signals controlling the early steps in ureteric bud (UB) branching. Due to the reported lethality of Wnt11 knockout embryos in utero, its role in later mammalian ki...

    Authors: Irina I. Nagy, Qi Xu, Florence Naillat, Nsrein Ali, Ilkka Miinalainen, Anatoly Samoylenko and Seppo J. Vainio

    Citation: BMC Developmental Biology 2016 16:30

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  45. Content type: Erratum

    Authors: Daniel Silberschmidt, Alina Rodriguez-Mallon, Prathiba Mithboakar, Gaetano Calì, Elena Amendola, Remo Sanges, Mariastella Zannini, Marzia Scarfò, Pasquale De Luca, Lucio Nitsch, Roberto Di Lauro and Mario De Felice

    Citation: BMC Developmental Biology 2016 16:29

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    The original article was published in BMC Developmental Biology 2011 11:9