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  1. Content type: Research article

    Sonic hedgehog (Shh) is an important signalling protein involved in the induction of early cartilaginous differentiation. Herein, we demonstrate that Shh markedly induces chondrogenesis of rabbit bone marrow s...

    Authors: Liyang Chen, Gejun Liu, Wenjun Li and Xing Wu

    Citation: BMC Developmental Biology 2019 19:18

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  2. Content type: Research article

    The Tet protein family (Tet1, Tet2, and Tet3) regulate DNA methylation through conversion of 5-methylcytosine to 5-hydroxymethylcytosine which can ultimately result in DNA demethylation and play a critical rol...

    Authors: Michael Reimer Jr, Kirthi Pulakanti, Linzheng Shi, Alex Abel, Mingyu Liang, Subramaniam Malarkannan and Sridhar Rao

    Citation: BMC Developmental Biology 2019 19:16

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  3. Content type: Research article

    Prostate androgen-regulated mucin-like protein 1 (PARM1) is a pro-proliferative and anti-apoptotic glycoprotein involved in the endoplasmic reticulum (ER) stress response. A single nucleotide polymorphism in t...

    Authors: Adriana M. Zolini, Verónica M. Negrón-Pérez and Peter J. Hansen

    Citation: BMC Developmental Biology 2019 19:15

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  4. Content type: Research article

    Insulin/insulin-like growth peptide signaling (IIS) down-regulates hemolymph sugar level and facilitates larval growth in the soybean pod borer, Maruca vitrata. The objective of this study is to determine whether...

    Authors: Md. Abdullah Al Baki, Dae-Weon Lee, Jin Kyo Jung and Yonggyun Kim

    Citation: BMC Developmental Biology 2019 19:14

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  5. Content type: Research article

    The segregation of the hypoblast and the emergence of the pluripotent epiblast mark the final stages of blastocyst formation in mammalian embryos. In bovine embryos the formation of the hypoblast has been part...

    Authors: Jesica R. Canizo, Amada E. Ynsaurralde Rivolta, Camila Vazquez Echegaray, Mariana Suvá, Virgilia Alberio, Juan F. Aller, Alejandra S. Guberman, Daniel F. Salamone, Ricardo H. Alberio and Ramiro Alberio

    Citation: BMC Developmental Biology 2019 19:13

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  6. Content type: Research article

    Alterations of bioelectrical properties of cells and tissues are known to function as wide-ranging signals during development, regeneration and wound-healing in several species. The Drosophila follicle-cell epith...

    Authors: Isabel Weiß and Johannes Bohrmann

    Citation: BMC Developmental Biology 2019 19:12

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  7. Content type: Research Article

    Progressive transformation of the otic placode into the functional inner ear during gestational development in humans leads to the acquisition of hearing perception via the cochlea and balance and spatial orie...

    Authors: Lejo Johnson Chacko, David Wertjanz, Consolato Sergi, Jozsef Dudas, Natalie Fischer, Theresa Eberharter, Romed Hoermann, Rudolf Glueckert, Helga Fritsch, Helge Rask-Andersen, Anneliese Schrott-Fischer and Stephan Handschuh

    Citation: BMC Developmental Biology 2019 19:11

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  8. Content type: Research article

    Cell differentiation is mediated by synchronized waves of coordinated expression for hundreds to thousands of genes, and must be regulated to produce complex tissues and phenotypes. For many animal species, se...

    Authors: Damien B. Wilburn and Richard C. Feldhoff

    Citation: BMC Developmental Biology 2019 19:10

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  9. Content type: Research article

    Coilia nasus oogenesis/spawning migration is a well-defined synchronous arrangement process. DnaJs are indispensable molecular chaperones for oogenesis process. However, how DnaJs involved the anadromous spawning...

    Authors: Xiao-ting Feng, Xue-jun Yang, Jian-jian Ruan, Ya-qi Wang, Yan-feng Zhou, Dong-po Xu and Di-an Fang

    Citation: BMC Developmental Biology 2019 19:9

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  10. Content type: Research article

    The interstitium of the mouse testis contains Leydig cells and a small number of steroidogenic cells with adrenal characteristics which may be derived from the fetal adrenal during development or may be a norm...

    Authors: Peter J. O’Shaughnessy, Rod T. Mitchell, Ana Monteiro, Laura O’Hara, Lyndsey Cruickshanks, Hedi Claahsen-van der Grinten, Pamela Brown, Margaret Abel and Lee B. Smith

    Citation: BMC Developmental Biology 2019 19:8

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  11. Content type: Research article

    NK genes are a group of homeobox transcription factors that are involved in various molecular pathways across bilaterians. They are typically divided into two subgroups, the NK cluster (NKC) and NK-linked gene...

    Authors: Sandra Treffkorn and Georg Mayer

    Citation: BMC Developmental Biology 2019 19:7

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  12. Content type: Research article

    C-lectin family 14 Member A (Clec14a) is a transmembrane protein specifically expressed in vascular endothelial cells during embryogenesis. Previous in vitro and in vivo studies have provided conflicting data ...

    Authors: Karolina Pociute, Jennifer A. Schumacher and Saulius Sumanas

    Citation: BMC Developmental Biology 2019 19:6

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  13. Content type: Research article

    The embryonic day E10–13 period of mouse heart development is characterized by robust cardiomyocyte proliferation that creates the compact zone of thickened ventricular wall myocardium. This process is initiat...

    Authors: Kai Wang, Hua Shen, Peiheng Gan, Susana Cavallero, S. Ram Kumar, Ching-Ling Lien and Henry M. Sucov

    Citation: BMC Developmental Biology 2019 19:5

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  14. Content type: Research article

    Knowledge about vitellogenesis in spiders is rudimentary. Therefore, the aim of study was to check the vitellogenin (Vg) presence in various tissues of the female spider Parasteatoda tepidariorum, determine when ...

    Authors: Agata W. Bednarek, Marta K. Sawadro, Łukasz Nicewicz and Agnieszka I. Babczyńska

    Citation: BMC Developmental Biology 2019 19:4

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  15. Content type: Methodology article

    Organoid cultivation in suspension culture requires agitation at low shear stress to allow for nutrient diffusion, which preserves tissue structure. Multiplex systems for organoid cultivation have been propose...

    Authors: Livia Goto-Silva, Nadia M. E. Ayad, Iasmin L. Herzog, Nilton P. Silva, Bernard Lamien, Helcio R. B. Orlande, Annie da Costa Souza, Sidarta Ribeiro, Michele Martins, Gilberto B. Domont, Magno Junqueira, Fernanda Tovar-Moll and Stevens K. Rehen

    Citation: BMC Developmental Biology 2019 19:3

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  16. Content type: Research article

    Work in other species suggests that interleukin-6 (IL6) promotes early embryo development. It was unclear whether IL6 serves as an embryokine in cultured bovine embryos. This work was undertaken to elucidate t...

    Authors: Lydia K. Wooldridge and Alan D. Ealy

    Citation: BMC Developmental Biology 2019 19:2

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  17. Content type: Methodology article

    BMP signaling is involved in myriad metazoan developmental processes, and study of this pathway in Drosophila has contributed greatly to our understanding of its molecular and genetic mechanisms. These studies ha...

    Authors: Scott J. Neal, Darin Dolezal, Nisveta Jusić and Francesca Pignoni

    Citation: BMC Developmental Biology 2019 19:1

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  18. Content type: Research article

    Previous studies have implicated a role for circadian clocks in regulating pre-adult development of organisms. Among them two approaches are most notable: 1) use of insects whose clocks have different free-run...

    Authors: Manishi Srivastava, Anjana James, Vishwanath Varma, Vijay Kumar Sharma and Vasu Sheeba

    Citation: BMC Developmental Biology 2018 18:21

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  19. Content type: Research article

    Histone modifications are critical in regulating neuronal processes. However, the impacts of individual histone modifications on learning and memory are elusive. Here, we investigated the contributions of hist...

    Authors: Kai-Le Li, Lei Zhang, Xiao-Mei Yang, Qiang Fang, Xue-Fang Yin, Hui-Min Wei, Ting Zhou, Ya-Bin Li, Xue-Lin Chen, Fan Tang, Yong-Hao Li, Jian-Feng Chang, Wei Li and Feng Sun

    Citation: BMC Developmental Biology 2018 18:20

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  20. Content type: Research article

    Integrins are transmembrane receptors that mediate cell–extracellular matrix (ECM) and cell-cell adhesion and trophoblast cells undergo changes in integrin expression as they differentiate. However, the mechan...

    Authors: Eiko Kawamura, Gina B. Hamilton, Ewa I. Miskiewicz and Daniel J. MacPhee

    Citation: BMC Developmental Biology 2018 18:19

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  21. Content type: Research article

    Mammalian brain is formed through neural tube closure (NTC), wherein both ridges of opposing neural folds are fused in the midline and remodeled in the roof plate of the neural tube and overlying non-neural ec...

    Authors: Naomi Shinotsuka, Yoshifumi Yamaguchi, Kenichi Nakazato, Yudai Matsumoto, Atsushi Mochizuki and Masayuki Miura

    Citation: BMC Developmental Biology 2018 18:17

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  22. Content type: Research article

    Alterations in maternal environment can sometimes affect embryonic development in a sexually-dimorphic manner. The objective was to determine whether preimplantation bovine embryos respond to three maternally-...

    Authors: Paula Tríbulo, Gulnur Jumatayeva, Khoboso Lehloenya, James I. Moss, Veronica M. Negrón-Pérez and Peter J. Hansen

    Citation: BMC Developmental Biology 2018 18:16

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  23. Content type: Research article

    Diabetes and hypothyroidism produce adverse effects on body weight and sexual maturity by inhibiting body growth and metabolism. The occurrence of diabetes is always accompanied with thyroid dysfunction. Thus,...

    Authors: Nazar Ali KOREJO, Quanwei WEI, Kaizhi ZHENG, Dagan MAO, Rashid Ali KOREJO, Atta Hussain SHAH and Fangxiong SHI

    Citation: BMC Developmental Biology 2018 18:15

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  24. Content type: Research article

    Dmrt2a is a zinc finger like transcription factor with several roles during zebrafish early development: left-right asymmetry, synchronisation of the somite clock genes and fast muscle differentiation. Despite...

    Authors: Rita Alexandra Pinto, José Almeida-Santos, Raquel Lourenço and Leonor Saúde

    Citation: BMC Developmental Biology 2018 18:14

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  25. Content type: Research article

    Pregnant women may be exposed to nicotine if they smoke or use tobacco products, nicotine replacement therapy, or via e-cigarettes. Prenatal nicotine exposure has been shown to have deleterious effects on the ...

    Authors: Melanie Morris, Ariel Shaw, Madison Lambert, Haley Halperin Perry, Eve Lowenstein, David Valenzuela and Norma Andrea Velazquez-Ulloa

    Citation: BMC Developmental Biology 2018 18:13

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  26. Content type: Research article

    The proliferating cell nuclear antigen (PCNA or PCN-1 in C. elegans), an essential processivity factor for DNA polymerase δ, has been widely used as a marker of S-phase. In C. elegans early embryos, PCN-1 accumul...

    Authors: Zuzana Kocsisova, Kerry Kornfeld and Tim Schedl

    Citation: BMC Developmental Biology 2018 18:12

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  27. Content type: Research article

    Honeybee development consists of four stages: embryo, larva, pupa and adult. Embryogenesis, a key process of cell division and differentiation, takes 3 days in honeybees. However, the embryonic transcriptome a...

    Authors: Xiaofen Hu, Li Ke, Zilong Wang and Zhijiang Zeng

    Citation: BMC Developmental Biology 2018 18:11

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  28. Content type: Research article

    Male European seabass, already predominant (~ 70%) in cultured stocks, show a high incidence (20–30%) of precocious sexual maturation under current aquaculture practices, leading to important economic losses f...

    Authors: Marco Graziano, Raul Benito, Josep V. Planas and Arjan P. Palstra

    Citation: BMC Developmental Biology 2018 18:10

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  29. Content type: Research article

    In this work we have determined molecular signatures of oviduct epithelial and progenitor cells. We have proposed a panel of selected marker genes, which correspond with the phenotype of oviduct cells of a lay...

    Authors: Katarzyna Stadnicka, Anna Sławińska, Aleksandra Dunisławska, Bertrand Pain and Marek Bednarczyk

    Citation: BMC Developmental Biology 2018 18:9

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  30. Content type: Research article

    The experimental approach to the evolution and development of the vertebrate skeleton has to a large extent relied on “direct-developing” amniote model organisms, such as the mouse and the chicken. These organ...

    Authors: Joost M. Woltering, Michaela Holzem, Ralf F. Schneider, Vasilios Nanos and Axel Meyer

    Citation: BMC Developmental Biology 2018 18:8

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  31. Content type: Review

    FK506-binding proteins (FKBPs) have become the subject of considerable interest in several fields, leading to the identification of several cellular and molecular pathways in which FKBPs impact prenatal develo...

    Authors: George Ghartey-Kwansah, Zhongguang Li, Rui Feng, Liyang Wang, Xin Zhou, Frederic Z. Chen, Meng Meng Xu, Odell Jones, Yulian Mu, Shawn Chen, Joseph Bryant, Williams B. Isaacs, Jianjie Ma and Xuehong Xu

    Citation: BMC Developmental Biology 2018 18:7

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  32. Content type: Research article

    Tbx5 deficiency in zebrafish causes several abnormal phenotypes of the heart and pectoral fins. It has been reported that exogenous human growth hormone can enhance expression of downstream mediators in the growt...

    Authors: Tzu-Chun Tsai, Chun-Che Shih, Hsin-Ping Chien, An-Hang Yang, Jenn-Kan Lu and Jen-Her Lu

    Citation: BMC Developmental Biology 2018 18:5

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  33. Content type: Research article

    Germ cell formation has been investigated in sessile forms of tunicates. This process involves the release of a subset of maternal transcripts from the centrosome-attracting body (CAB) in the progenitor cells ...

    Authors: Lisbeth Charlotte Olsen, Ioannis Kourtesis, Henriette Busengdal, Marit Flo Jensen, Harald Hausen and Daniel Chourrout

    Citation: BMC Developmental Biology 2018 18:4

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  34. Content type: Research article

    MiR-9 is a small non-coding RNA that is highly conserved between species and primarily expressed in the central nervous system (CNS). It is known to influence proliferation and neuronal differentiation in the ...

    Authors: A. Alwin Prem Anand, Carola Huber, John Asnet Mary, Nancy Gallus, Christoph Leucht, Ruth Klafke, Bernhard Hirt and Andrea Wizenmann

    Citation: BMC Developmental Biology 2018 18:3

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  35. Content type: Research article

    The compound eyes of insects allow them to catch photons and convert the energy into electric signals. All compound eyes consist of numerous ommatidia, each comprising a fixed number of photoreceptors. Differe...

    Authors: Leonie Lichtenstein, Kornelia Grübel and Johannes Spaethe

    Citation: BMC Developmental Biology 2018 18:1

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  36. Content type: Research article

    All animals have mechanisms for healing damage to the epithelial sheets that cover the body and line internal cavities. Epithelial wounds heal either by cells crawling over the wound gap, by contraction of a s...

    Authors: Zach Kamran, Katie Zellner, Harry Kyriazes, Christine M. Kraus, Jean-Baptiste Reynier and Jocelyn E. Malamy

    Citation: BMC Developmental Biology 2017 17:17

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  37. Content type: Research article

    Over one third of all animal phyla utilize a mode of early embryogenesis called ‘spiral cleavage’ to divide the fertilized egg into embryonic cells with different cell fates. This mode is characterized by a se...

    Authors: Aron B. Nakama, Hsien-Chao Chou and Stephan Q. Schneider

    Citation: BMC Developmental Biology 2017 17:16

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  38. Content type: Methodology article

    The Midas cichlid species complex (Amphilophus spp.) is widely known among evolutionary biologists as a model system for sympatric speciation and adaptive phenotypic divergence within extremely short periods of t...

    Authors: Claudius F. Kratochwil, Maggie M. Sefton, Yipeng Liang and Axel Meyer

    Citation: BMC Developmental Biology 2017 17:15

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  39. Content type: Research article

    The Runt-related transcription factors (Runx) are a family of evolutionarily conserved transcriptional regulators that play multiple roles in the developmental control of various cell types. Among the three ma...

    Authors: Sebastian Nieke, Nighat Yasmin, Kiyokazu Kakugawa, Tomomasa Yokomizo, Sawako Muroi and Ichiro Taniuchi

    Citation: BMC Developmental Biology 2017 17:14

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  40. Content type: Research article

    Vertebrate head development depends on a series of interactions between many cell populations of distinct embryological origins. Cranial mesenchymal tissues have a dual embryonic source: - the neural crest (NC...

    Authors: Barbara F. Fonseca, Gérard Couly and Elisabeth Dupin

    Citation: BMC Developmental Biology 2017 17:13

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  41. Content type: Research article

    The quality and yield of duck feathers are very important economic traits that might be controlled by miRNA regulation. The aim of the present study was to investigate the mechanism underlying the crosstalk be...

    Authors: Xingyong Chen, Kai Ge, Min Wang, Cheng Zhang and Zhaoyu Geng

    Citation: BMC Developmental Biology 2017 17:12

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  42. Content type: Research article

    The identification of DNA methyltransferases (Dnmt) expression patterns during development and their regulation is important to understand the epigenetic mechanisms that modulate larval plasticity in marine fi...

    Authors: Joana Firmino, Carlos Carballo, Paula Armesto, Marco A. Campinho, Deborah M. Power and Manuel Manchado

    Citation: BMC Developmental Biology 2017 17:11

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  43. Content type: Research article

    Cathepsin B is a lysosomal cysteine protease involved in apoptosis and oocytes which have lower developmental competence show higher expression of Cathepsin B. Furthermore, expression of Cathepsin B show a dec...

    Authors: M. Pezhman, S. M. Hosseini, S. Ostadhosseini, Sh. Rouhollahi Varnosfaderani, F. Sefid and M. H. Nasr-Esfahani

    Citation: BMC Developmental Biology 2017 17:10

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  44. Content type: Research article

    Mitochondrial alternative respiratory-chain enzymes are phylogenetically widespread, and buffer stresses affecting oxidative phosphorylation in species that possess them. However, they have been lost in the ev...

    Authors: Sina Saari, Ana Andjelković, Geovana S. Garcia, Howard T. Jacobs and Marcos T. Oliveira

    Citation: BMC Developmental Biology 2017 17:9

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  45. Content type: Research article

    The tauGFP reporter fusion protein is produced nearly ubiquitously by the TgTP6.3 transgene in TP6.3 mice and its localisation to microtubules offers some advantages over soluble GFP as a lineage marker. However,...

    Authors: Linda Sharp, Thomas Pratt, Gillian E. MacKay, Margaret A. Keighren, Jean H. Flockhart, Emma J. Chandler, David J. Price, John O. Mason and John D. West

    Citation: BMC Developmental Biology 2017 17:8

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