Skip to main content

Advertisement

Articles

Page 6 of 20

  1. Group B Sox domain transcription factors play important roles in metazoan central nervous system development. They are, however, difficult to study as mutations often have pleiotropic effects and other Sox fam...

    Authors: Shih Pei Shen, Jelena Aleksic and Steven Russell

    Citation: BMC Developmental Biology 2013 13:1

    Content type: Research article

    Published on:

  2. Members of the family Syngnathidae share a unique reproductive mode termed male pregnancy. Males carry eggs in specialised brooding structures for several weeks and release free-swimming offspring. Here we des...

    Authors: Stefan Sommer, Camilla M Whittington and Anthony B Wilson

    Citation: BMC Developmental Biology 2012 12:39

    Content type: Research article

    Published on:

  3. Magnetic resonance imaging is a noninvasive method of evaluating embryonic development. Diffusion tensor imaging (DTI), based on the directional diffusivity of water molecules, is an established method of eval...

    Authors: Zien Zhou, Zachary DelProposto, Lianming Wu, Jianrong Xu, Jia Hua, Yan Zhou, Yongquan Ye, Zishu Zhang, Jiani Hu and E Mark Haacke

    Citation: BMC Developmental Biology 2012 12:38

    Content type: Methodology article

    Published on:

  4. Genetic studies in mouse have demonstrated the crucial function of PAX4 in pancreatic cell differentiation. This transcription factor specifies β- and δ-cell fate at the expense of α-cell identity by repressing A...

    Authors: Joachim Djiotsa, Vincianne Verbruggen, Jean Giacomotto, Minaka Ishibashi, Elisabeth Manning, Silke Rinkwitz, Isabelle Manfroid, Marianne L Voz and Bernard Peers

    Citation: BMC Developmental Biology 2012 12:37

    Content type: Research article

    Published on:

  5. In mammals, R-spondin (Rspo), an activator of the Wnt/β-catenin signaling pathway, has been shown to be involved in ovarian differentiation. However, the role of the Rspo/Wnt/β-catenin signaling pathway in fis...

    Authors: Linyan Zhou, Tapas Charkraborty, Xiangguo Yu, Limin Wu, Gang Liu, Sipra Mohapatra, Deshou Wang and Yoshitaka Nagahama

    Citation: BMC Developmental Biology 2012 12:36

    Content type: Research article

    Published on:

  6. The proper balance of autophagy, a lysosome-mediated degradation process, is indispensable for oogenesis in Drosophila. We recently demonstrated that egg development depends on autophagy in the somatic follicle c...

    Authors: Julia MI Barth, Ernst Hafen and Katja Köhler

    Citation: BMC Developmental Biology 2012 12:35

    Content type: Research article

    Published on:

  7. The contribution of cell proliferation to regeneration varies greatly between different metazoan models. Planarians rely on pluripotent neoblasts and amphibian limb regeneration depends upon formation of a pro...

    Authors: Yale J Passamaneck and Mark Q Martindale

    Citation: BMC Developmental Biology 2012 12:34

    Content type: Research article

    Published on:

  8. The first distinct differentiation event in mammals occurs at the blastocyst stage when totipotent blastomeres differentiate into either pluripotent inner cell mass (ICM) or multipotent trophectoderm (TE). Her...

    Authors: Manabu Ozawa, Miki Sakatani, JiQiang Yao, Savita Shanker, Fahong Yu, Rui Yamashita, Shunichi Wakabayashi, Kenta Nakai, Kyle B Dobbs, Mateus José Sudano, William G Farmerie and Peter J Hansen

    Citation: BMC Developmental Biology 2012 12:33

    Content type: Research article

    Published on:

  9. Temperature affects virtually all cellular processes. A quick increase in temperature challenges the cells to undergo a heat shock response to maintain cellular homeostasis. Heat shock factor-1 (HSF-1) functio...

    Authors: János Barna, Andrea Princz, Mónika Kosztelnik, Balázs Hargitai, Krisztina Takács-Vellai and Tibor Vellai

    Citation: BMC Developmental Biology 2012 12:32

    Content type: Research article

    Published on:

  10. Oxygen sensing is a near universal signaling modality that, in eukaryotes ranging from protists such as Dictyostelium and Toxoplasma to humans, involves a cytoplasmic prolyl 4-hydroxylase that utilizes oxygen and...

    Authors: Yuechi Xu, Zhuo A Wang, Rebekah S Green and Christopher M West

    Citation: BMC Developmental Biology 2012 12:31

    Content type: Research article

    Published on:

  11. Embryonic development proceeds through finely tuned reprogramming of the parental genomes to form a totipotent embryo. Cells within this embryo will then differentiate and give rise to all the tissues of a new...

    Authors: Tiphaine Aguirre-Lavin, Pierre Adenot, Amélie Bonnet-Garnier, Gaétan Lehmann, Renaud Fleurot, Claire Boulesteix, Pascale Debey and Nathalie Beaujean

    Citation: BMC Developmental Biology 2012 12:30

    Content type: Research article

    Published on:

  12. Hox proteins are transcription factors involved in crucial processes during animal development. Their mode of action remains scantily documented. While other families of transcription factors, like Smad or Sta...

    Authors: Barbara Lambert, Julie Vandeputte, Sophie Remacle, Isabelle Bergiers, Nicolas Simonis, Jean-Claude Twizere, Marc Vidal and René Rezsohazy

    Citation: BMC Developmental Biology 2012 12:29

    Content type: Research article

    Published on:

  13. In chondrichthyans, basal osteichthyans and tetrapods, vertebral bodies have cartilaginous anlagen that subsequently mineralize (chondrichthyans) or ossify (osteichthyans). Chondrocytes that form the vertebral...

    Authors: Anabela Bensimon-Brito, João Cardeira, Maria Leonor Cancela, Ann Huysseune and Paul Eckhard Witten

    Citation: BMC Developmental Biology 2012 12:28

    Content type: Research article

    Published on:

  14. The multicellular slug in Dictyostelium has a single tip that acts as an organising centre patterning the rest of the slug. High adenosine levels at the tip are believed to be responsible for this tip dominance a...

    Authors: Pundrik Jaiswal, Shashi Prakash Singh, Prasad Aiyar, Rakhil Akkali and Ramamurthy Baskar

    Citation: BMC Developmental Biology 2012 12:26

    Content type: Research article

    Published on:

  15. Secreted frizzled-related proteins (SFRPs) are a family of proteins that block the Wnt signaling pathway and loss of SFRP1 expression is found in breast cancer along with a multitude of other human cancers. Ac...

    Authors: Kelly J Gauger, Akihiko Shimono, Giovanna M Crisi and Sallie Smith Schneider

    Citation: BMC Developmental Biology 2012 12:25

    Content type: Research article

    Published on:

  16. Zebrafish has emerged as a powerful model organism to study the process of regeneration. This teleost fish has the ability to regenerate various tissues and organs like the heart, spinal cord, retina and fins....

    Authors: Ana Sofia Azevedo, Sara Sousa, António Jacinto and Leonor Saúde

    Citation: BMC Developmental Biology 2012 12:24

    Content type: Research article

    Published on:

  17. Mouse limb bud is a prime model to study the regulatory interactions that control vertebrate organogenesis. Major aspects of limb bud development are controlled by feedback loops that define a self-regulatory ...

    Authors: Aimée Zuniga, Frédéric Laurent, Javier Lopez-Rios, Christian Klasen, Nicolas Matt and Rolf Zeller

    Citation: BMC Developmental Biology 2012 12:23

    Content type: Research article

    Published on:

  18. Valvulogenesis and septation in the developing heart depend on the formation and remodeling of endocardial cushions in the atrioventricular canal (AVC) and outflow tract (OFT). These cushions are invaded by a ...

    Authors: Kathryn E LeMasters, Yotam Blech-Hermoni, Samantha J Stillwagon, Natalie A Vajda and Andrea N Ladd

    Citation: BMC Developmental Biology 2012 12:22

    Content type: Research article

    Published on:

  19. Calpains are calcium regulated intracellular cysteine proteases implicated in a variety of physiological functions and pathological conditions. The Drosophila melanogaster genome contains only two genes, CalpA an...

    Authors: Endre Kókai, Ferencz Sándor Páldy, Kálmán Somogyi, Anil Chougule, Margit Pál, Éva Kerekes, Péter Deák, Péter Friedrich, Viktor Dombrádi and Géza Ádám

    Citation: BMC Developmental Biology 2012 12:20

    Content type: Research article

    Published on:

  20. The peptidylarginine deiminases (PADIs) convert positively charged arginine residues to neutrally charged citrulline on protein substrates in a process that is known as citrullination or deimination. Previous ...

    Authors: Rui Kan, Mei Jin, Venkataraman Subramanian, Corey P Causey, Paul R Thompson and Scott A Coonrod

    Citation: BMC Developmental Biology 2012 12:19

    Content type: Research article

    Published on:

  21. To facilitate the in vivo study of esophageal (stem) cell biology in homeostasis and cancer, novel mouse models are necessary to elicit expression of candidate genes in a tissue-specific and inducible fashion. To...

    Authors: Sabrina Roth, Patrick Franken, Kim Monkhorst, John Kong a San and Riccardo Fodde

    Citation: BMC Developmental Biology 2012 12:18

    Content type: Methodology article

    Published on:

  22. Wnts are a family of secreted signaling molecules involved in a number of developmental processes including the establishment of cell fate, polarity and proliferation. Recent studies also implicate wnts in epi...

    Authors: Macalister Usongo and Riaz Farookhi

    Citation: BMC Developmental Biology 2012 12:17

    Content type: Research article

    Published on:

  23. Histone deacetylase-4 (Hdac4) is a class II histone deacetylase that inhibits the activity of transcription factors. In humans, HDAC4 deficiency is associated with non-syndromic oral clefts and brachydactyly m...

    Authors: April DeLaurier, Yukio Nakamura, Ingo Braasch, Vishesh Khanna, Hiroyuki Kato, Shigeyuki Wakitani, John H Postlethwait and Charles B Kimmel

    Citation: BMC Developmental Biology 2012 12:16

    Content type: Research article

    Published on:

  24. A hallmark of Drosophila segmentation is the stepwise subdivision of the body into smaller and smaller units, and finally into the segments. This is achieved by the function of the well-understood segmentation ge...

    Authors: Ralf Janssen, Wim G M Damen and Graham E Budd

    Citation: BMC Developmental Biology 2012 12:15

    Content type: Research article

    Published on:

  25. A metamorphic life-history is present in the majority of animal phyla. This developmental mode is particularly prominent among marine invertebrates with a bentho-planktonic life cycle, where a pelagic larval f...

    Authors: Josh Sutherby, Jamie-Lee Giardini, Julia Nguyen, Gary Wessel, Mariana Leguia and Andreas Heyland

    Citation: BMC Developmental Biology 2012 12:14

    Content type: Research article

    Published on:

    The Erratum to this article has been published in BMC Developmental Biology 2013 13:30

  26. The mammary gland is key to all mammal species; in particular in multiparous species like pigs the number and the shape of functional mammary gland complexes are major determinants of fitness. Accordingly, we ...

    Authors: Kunsuda Chomwisarutkun, Eduard Murani, Siriluck Ponsuksili and Klaus Wimmers

    Citation: BMC Developmental Biology 2012 12:13

    Content type: Research article

    Published on:

  27. Folic acid supplementation reduces the risk of neural tube defects and congenital heart defects. The biological mechanisms through which folate prevents birth defects are not well understood. We explore the us...

    Authors: Marina S Lee, Jenna R Bonner, David J Bernard, Erica L Sanchez, Eric T Sause, R Reid Prentice, Shawn M Burgess and Lawrence C Brody

    Citation: BMC Developmental Biology 2012 12:12

    Content type: Research article

    Published on:

  28. Among the four major bilaterian clades, Deuterostomia, Acoelomorpha, Ecdysozoa, and Lophotrochozoa, the latter shows an astonishing diversity of bodyplans. While the largest lophotrochozoan assemblage, the Spi...

    Authors: Julia Merkel, Tim Wollesen, Bernhard Lieb and Andreas Wanninger

    Citation: BMC Developmental Biology 2012 12:11

    Content type: Research article

    Published on:

  29. During early stages of brain development, secreted molecules, components of intracellular signaling pathways and transcriptional regulators act in positive and negative feed-back or feed-forward loops at the m...

    Authors: Zsuzsa Agoston, Naixin Li, Anja Haslinger, Andrea Wizenmann and Dorothea Schulte

    Citation: BMC Developmental Biology 2012 12:10

    Content type: Research article

    Published on:

  30. Mammals are not able to restore lost appendages, while many amphibians are. One important question about epimorphic regeneration is related to the origin of the new tissues and whether they come from mature ce...

    Authors: Alexandre Miguel Cavaco Rodrigues, Bea Christen, Mercé Martí and Juan Carlos Izpisúa Belmonte

    Citation: BMC Developmental Biology 2012 12:9

    Content type: Research article

    Published on:

  31. The formation of a tubular organ, such as the heart, requires the communication of positional and polarity signals between migratory cells. Key to this process is the establishment of a new luminal domain on t...

    Authors: Jessica Vanderploeg, L Lourdes Vazquez Paz, Allison MacMullin and J Roger Jacobs

    Citation: BMC Developmental Biology 2012 12:8

    Content type: Research article

    Published on:

  32. Multipotent stem cells have been successfully isolated from various tissues and are currently utilized for tissue-engineering and cell-based therapies. Among the many sources, skin has recently emerged as an a...

    Authors: Radhakrishnan Vishnubalaji, Muthurangan Manikandan, May Al-Nbaheen, Balamuthu Kadalmani, Abdullah Aldahmash and Nehad M Alajez

    Citation: BMC Developmental Biology 2012 12:7

    Content type: Research article

    Published on:

  33. Because of the structural and molecular similarities between the two systems, the lateral line, a fish and amphibian specific sensory organ, has been widely used in zebrafish as a model to study the developmen...

    Authors: Martine Behra, Viviana E Gallardo, John Bradsher, Aranza Torrado, Abdel Elkahloun, Jennifer Idol, Jessica Sheehy, Seth Zonies, Lisha Xu, Kenna M Shaw, Chie Satou, Shin-ichi Higashijima, Brant M Weinstein and Shawn M Burgess

    Citation: BMC Developmental Biology 2012 12:6

    Content type: Research article

    Published on:

  34. Multicellularity in cellular slime molds is achieved by aggregation of several hundreds to thousands of cells. In the model slime mold Dictyostelium discoideum, adenosine is known to increase the aggregate size a...

    Authors: Pundrik Jaiswal, Thierry Soldati, Sascha Thewes and Ramamurthy Baskar

    Citation: BMC Developmental Biology 2012 12:5

    Content type: Research article

    Published on:

  35. Germline stem cells (GSCs) are present in the gonads of Drosophila females and males, and their proper maintenance, as well as their correct differentiation, is essential for fertility and fecundity. The molec...

    Authors: Amy C Cash and Justen Andrews

    Citation: BMC Developmental Biology 2012 12:4

    Content type: Research article

    Published on:

  36. Cell adhesion, an integral part of D. discoideum development, is important for morphogenesis and regulated gene expression in the multicellular context and is required to trigger cell-differentiation. G-protein l...

    Authors: Hameeda Sultana, Girish Neelakanta, Francisco Rivero, Rosemarie Blau-Wasser, Michael Schleicher and Angelika A Noegel

    Citation: BMC Developmental Biology 2012 12:3

    Content type: Research article

    Published on:

  37. Kangaroos and wallabies have specialised limbs that allow for their hopping mode of locomotion. The hindlimbs differentiate much later in development but become much larger than the forelimbs. The hindlimb aut...

    Authors: Keng Yih Chew, Hongshi Yu, Andrew J Pask, Geoffrey Shaw and Marilyn B Renfree

    Citation: BMC Developmental Biology 2012 12:2

    Content type: Research article

    Published on:

  38. The desmosomal cadherins (DCs), desmocollin (Dsc) and desmoglein (Dsg), are the adhesion molecules of desmosomes, intercellular adhesive junctions of epithelia and cardiac muscle. Both the DCs and desmosomes h...

    Authors: Alexander Goonesinghe, Xing-Ming Luan, Adam Hurlstone and David Garrod

    Citation: BMC Developmental Biology 2012 12:1

    Content type: Research article

    Published on:

    The Erratum to this article has been published in BMC Developmental Biology 2014 14:13

  39. Hemangioblasts are known as the common precursors for primitive hematopoietic and endothelial lineages. Their existence has been supported mainly by the observation that both cell types develop in close proxim...

    Authors: Vera Teixeira, Natacha Arede, Rui Gardner, Joaquín Rodríguez-León and Ana T Tavares

    Citation: BMC Developmental Biology 2011 11:76

    Content type: Methodology article

    Published on:

  40. The lung and thyroid are derived from the anterior endoderm. Retinoic acid and Fgf signalling are known to be essential for development of the lung in mouse but little is known on how the lung and thyroid are ...

    Authors: Jean H Wang, Steven J Deimling, Nicole E D'Alessandro, Lin Zhao, Fred Possmayer and Thomas A Drysdale

    Citation: BMC Developmental Biology 2011 11:75

    Content type: Research article

    Published on:

  41. The molecular mechanism that initiates the formation of the vertebrate central nervous system has long been debated. Studies in Xenopus and mouse demonstrate that inhibition of BMP signaling is sufficient to indu...

    Authors: Crystal D Rogers, George S Ferzli and Elena S Casey

    Citation: BMC Developmental Biology 2011 11:74

    Content type: Research article

    Published on:

  42. Desert hedgehog (DHH) belongs to the hedgehog gene family that act as secreted intercellular signal transducers. DHH is an essential morphogen for normal testicular development and function in both mice and human...

    Authors: William A O'Hara, Walid J Azar, Richard R Behringer, Marilyn B Renfree and Andrew J Pask

    Citation: BMC Developmental Biology 2011 11:72

    Content type: Research article

    Published on:

  43. Genetic alterations in human topoisomerase II alpha (TOP2A) are linked to cancer susceptibility. TOP2A decatenates chromosomes and thus is necessary for multiple aspects of cell division including DNA replication...

    Authors: Beata Sapetto-Rebow, Sarah C McLoughlin, Lynne C O'Shea, Olivia O'Leary, Jason R Willer, Yolanda Alvarez, Ross Collery, Jacintha O'Sullivan, Freek Van Eeden, Carmel Hensey and Breandán N Kennedy

    Citation: BMC Developmental Biology 2011 11:71

    Content type: Research article

    Published on:

  44. The molecular mechanisms governing vertebrate appendage regeneration remain poorly understood. Uncovering these mechanisms may lead to novel therapies aimed at alleviating human disfigurement and visible loss ...

    Authors: Nick R Love, Yaoyao Chen, Boyan Bonev, Michael J Gilchrist, Lynne Fairclough, Robert Lea, Timothy J Mohun, Roberto Paredes, Leo AH Zeef and Enrique Amaya

    Citation: BMC Developmental Biology 2011 11:70

    Content type: Research article

    Published on:

  45. The freshwater planarian Schmidtea mediterranea exhibits two distinct reproductive modes. Individuals of the sexual strain are cross-fertilizing hermaphrodites with reproductive organs that develop post-embryonic...

    Authors: Tracy Chong, Joel M Stary, Yuying Wang and Phillip A Newmark

    Citation: BMC Developmental Biology 2011 11:69

    Content type: Research article

    Published on:

  46. Neural crest cells (NCCs) are embryonic, multipotent stem cells. Their long-range and precision-guided migration is one of their most striking characteristics. We previously reported that P0-Cre/CAG-CAT-lacZ doub...

    Authors: Minoru Kawakami, Masafumi Umeda, Naomi Nakagata, Toru Takeo and Ken-ichi Yamamura

    Citation: BMC Developmental Biology 2011 11:68

    Content type: Research article

    Published on:

  47. Progesterone triggers resumption of the first meiotic division in the Rana pipiens oocyte by binding to the N-terminal external loop of the catalytic subunit of Na/K-ATPase, releasing a cascade of lipid second me...

    Authors: Gene A Morrill, Terry L Dowd, Adele B Kostellow and Raj K Gupta

    Citation: BMC Developmental Biology 2011 11:67

    Content type: Research article

    Published on: