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  1. Content type: Research article

    Haploinsufficiency of the FOXL2 transcription factor in humans causes Blepharophimosis/Ptosis/Epicanthus Inversus syndrome (BPES), characterized by eyelid anomalies and premature ovarian failure. Mice lacking Fox...

    Authors: Mara Marongiu, Loredana Marcia, Emanuele Pelosi, Mario Lovicu, Manila Deiana, Yonqing Zhang, Alessandro Puddu, Angela Loi, Manuela Uda, Antonino Forabosco, David Schlessinger and Laura Crisponi

    Citation: BMC Developmental Biology 2015 15:27

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  2. Content type: Research article

    MicroRNAs (miRNAs) are small noncoding RNAs that act as post-transcriptional regulators of gene targets. Accurate quantification of miRNA expression using validated internal controls should aid in the understa...

    Authors: Mahdi Mahdipour, Helena T.A. van Tol, Tom A.E. Stout and Bernard A.J. Roelen

    Citation: BMC Developmental Biology 2015 15:25

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  3. Content type: Methodology article

    During the fourth larval (L4) stage, vulval cells of C. elegans undergo extensive morphogenesis accompanied by changes in gene expression. This phase of vulval development, occurring after the well-studied induct...

    Authors: Darren Z. L. Mok, Paul W. Sternberg and Takao Inoue

    Citation: BMC Developmental Biology 2015 15:26

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  4. Content type: Research Article

    Adult echinoderms can completely regenerate major parts of their central nervous system even after severe injuries. Even though this capacity has long been known, the molecular mechanisms that drive fast and c...

    Authors: Vladimir S Mashanov, Olga R Zueva and José E García-Arrarás

    Citation: BMC Developmental Biology 2015 15:24

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  5. Content type: Research article

    HP1γ, a well-known regulator of gene expression, has been recently identified to be a target of Aurora A, a mitotic kinase which is important for both gametogenesis and embryogenesis. The purpose of this study...

    Authors: Phoebe H. Leonard, Adrienne Grzenda, Angela Mathison, Dean E. Morbeck, Jolene R. Fredrickson, Thiago M. de Assuncao, Trace Christensen, Jeffrey Salisbury, Ezequiel Calvo, Juan Iovanna, Charles C. Coddington, Raul Urrutia and Gwen Lomberk

    Citation: BMC Developmental Biology 2015 15:23

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  6. Content type: Research article

    Despite extensive knowledge on bivalve anatomy and development, the formation and differentiation of the mantle margin and its associated organs remain largely unclear. Bivalves from the family Pectinidae (sca...

    Authors: Jorge A. Audino, José Eduardo A. R. Marian, Andreas Wanninger and Sônia G. B. C. Lopes

    Citation: BMC Developmental Biology 2015 15:22

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  7. Content type: Research article

    The mouse embryonic mandible comprises two types of tooth primordia in the cheek region: progressive tooth primordia of prospective functional teeth and rudimentary tooth primordia in premolar region – MS and ...

    Authors: Katerina Lochovska, Renata Peterkova, Zuzana Pavlikova and Maria Hovorakova

    Citation: BMC Developmental Biology 2015 15:21

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  8. Content type: Research article

    Endothelial or epithelial cellular branching is vital in development and cancer progression; however, the molecular mechanisms of these processes are not clear. In Drosophila, terminal cell at the end of some tra...

    Authors: Matthew Man-Kin Wong, Ming-Fai Liu and Sung Kay Chiu

    Citation: BMC Developmental Biology 2015 15:20

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  9. Content type: Methodology article

    The ability to visualise the expression of individual genes in situ is an invaluable tool for developmental and evolutionary biologists; it allows for the characterisation of gene function, gene regulation and th...

    Authors: Jennifer Hohagen, Ines Herlitze and Daniel John Jackson

    Citation: BMC Developmental Biology 2015 15:19

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  10. Content type: Research article

    The developing eye receives blood supply from two vascular systems, the intraocular hyaloid system and the superficial choroidal vessels. In zebrafish, a highly stereotypic and simple set of vessels develops o...

    Authors: Rivka Kaufman, Omri Weiss, Meyrav Sebbagh, Revital Ravid, Liron Gibbs-Bar, Karina Yaniv and Adi Inbal

    Citation: BMC Developmental Biology 2015 15:18

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  11. Content type: Research article

    Marsupials such as the tammar wallaby (M.Eugenii) have a short gestation (29.3 days) and at birth the altricial young resembles a fetus, and the major development occurs postnatally while the young remains in the...

    Authors: Vengamanaidu Modepalli, Lyn A Hinds, Julie A Sharp, Christophe Lefevre and Kevin R Nicholas

    Citation: BMC Developmental Biology 2015 15:16

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  12. Content type: Research article

    There is increasing evidence of a pivotal role for regulated mRNA translation in control of developmental cell fate transitions. Physiological and pathological stem and progenitor cell self-renewal is maintain...

    Authors: Angus M MacNicol, Linda L Hardy, Horace J Spencer and Melanie C MacNicol

    Citation: BMC Developmental Biology 2015 15:15

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  13. Content type: Research article

    Human dental pulp represents a suitable alternative source of stem cells for the purpose of cell-based therapies in regenerative medicine, because it is relatively easy to obtain it, using low invasive procedu...

    Authors: Alessandra Pisciotta, Gianluca Carnevale, Simona Meloni, Massimo Riccio, Sara De Biasi, Lara Gibellini, Adriano Ferrari, Giacomo Bruzzesi and Anto De Pol

    Citation: BMC Developmental Biology 2015 15:14

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  14. Content type: Research article

    In mammals, maternal differentially methylated regions (DMRs) acquire DNA methylation during the postnatal growth stage of oogenesis, with paternal DMRs acquiring DNA methylation in the perinatal prospermatago...

    Authors: Alan M O’Doherty, David A Magee, Lynee C O’Shea, Niamh Forde, Marijke E Beltman, Solomon Mamo and Trudee Fair

    Citation: BMC Developmental Biology 2015 15:13

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  15. Content type: Research article

    Central American crater lake cichlid fish of the Midas species complex (Amphilophus spp.) are a model system for sympatric speciation and fast ecological diversification and specialization. Midas cichlids have be...

    Authors: Claudius F Kratochwil, Maggie M Sefton and Axel Meyer

    Citation: BMC Developmental Biology 2015 15:12

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  16. Content type: Research article

    Primary cilia are essential for Hedgehog (Hh) signal transduction in vertebrates. Although the core components of the Hh pathway are highly conserved, the dependency on cilia in Hh signaling is considered to b...

    Authors: Takayoshi Yamamoto, Tatsuya Tsukahara, Tadashi Ishiguro, Haruo Hagiwara, Masanori Taira and Hiroyuki Takeda

    Citation: BMC Developmental Biology 2015 15:9

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  17. Content type: Methodology article

    Tissue fixation is crucial for preserving the morphology of biological structures and cytological details to prevent postmortem degradation and autolysis. Improper fixation conditions could lead to artifacts a...

    Authors: Jing Nie, Simpla Mahato and Andrew C Zelhof

    Citation: BMC Developmental Biology 2015 15:10

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  18. Content type: Research article

    Stem cells can respond to environmental and physiological inputs to adaptively remodel tissues. Little is known about whether stem cell niches are similarly responsive. The Drosophila ovary germline stem cell (GS...

    Authors: Alessandro Bonfini, Marian B Wilkin and Martin Baron

    Citation: BMC Developmental Biology 2015 15:8

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  19. Content type: Research article

    Alveoli, the milk-producing units of the mammary gland, are generated during pregnancy by collaboration of different epithelial cell types. We present the first analysis of transcriptional changes within the h...

    Authors: Duvini De Silva, Kamini Kunasegaran, Sujoy Ghosh and Alexandra M Pietersen

    Citation: BMC Developmental Biology 2015 15:7

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  20. Content type: Research article

    We have revealed that the type II diacylglycerol kinases (DGKs) δ, η and κ were expressed in the testis and ovary. However, these enzymes’ functions in the reproductive organs remain unknown.

    Authors: Takao Shionoya, Takako Usuki, Suguru Komenoi, Takeshi Isozaki, Hiromichi Sakai and Fumio Sakane

    Citation: BMC Developmental Biology 2015 15:6

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  21. Content type: Research article

    Dietary interventions during pregnancy alter offspring fitness. We have shown mouse maternal low protein diet fed exclusively for the preimplantation period (Emb-LPD) before return to normal protein diet (NPD)...

    Authors: Congshan Sun, Oleg Denisenko, Bhavwanti Sheth, Andy Cox, Emma S Lucas, Neil R Smyth and Tom P Fleming

    Citation: BMC Developmental Biology 2015 15:3

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  22. Content type: Research article

    In society, there is a clear need to improve the success rate of techniques to restore fertility. Therefore a deeper knowledge of the dynamics of the complex molecular environment that regulates human gametoge...

    Authors: A Marijne Heeren, Liesbeth van Iperen, Daniëlle B Klootwijk, Ana de Melo Bernardo, Matthias S Roost, Maria M Gomes Fernandes, Leonie A Louwe, Carina G Hilders, Frans M Helmerhorst, Lucette A J van der Westerlaken and Susana M Chuva de Sousa Lopes

    Citation: BMC Developmental Biology 2015 15:4

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  23. Content type: Methodology article

    Planarians are an attractive model organism for studying stem cell-based regeneration due to their ability to replace all of their tissues from a population of adult stem cells. The molecular toolkit for plana...

    Authors: Kelly G Ross, Kerilyn C Omuro, Matthew R Taylor, Roma K Munday, Amy Hubert, Ryan S King and Ricardo M Zayas

    Citation: BMC Developmental Biology 2015 15:2

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  24. Content type: Reviewer acknowledgement

    The editors of BMC Developmental Biology would like to thank all our reviewers who have contributed to the journal in Volume 14 (2014).

    Authors: Philippa K Harris

    Citation: BMC Developmental Biology 2015 15:5

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  25. Content type: Research article

    Bioelectric phenomena have been found to exert influence on various developmental and regenerative processes. Little is known about their possible functions and the cellular mechanisms by which they might act ...

    Authors: Julia Krüger and Johannes Bohrmann

    Citation: BMC Developmental Biology 2015 15:1

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  26. Content type: Research article

    Zebrafish are able to regenerate many of its tissues and organs after damage. In amphibians this process is regulated by nerve fibres present at the site of injury, which have been proposed to release factors ...

    Authors: Mariana G Simões, Anabela Bensimon-Brito, Mariana Fonseca, Ana Farinho, Fábio Valério, Sara Sousa, Nuno Afonso, Anoop Kumar and Antonio Jacinto

    Citation: BMC Developmental Biology 2014 14:49

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  27. Content type: Methodology article

    Efforts to elucidate the cellular and molecular mechanisms of regeneration have required the application of methods to detect specific cell types and tissues in a growing cohort of experimental animal models. ...

    Authors: David J Forsthoefel, Forrest A Waters and Phillip A Newmark

    Citation: BMC Developmental Biology 2014 14:45

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  28. Content type: Methodology article

    Mapping of tissue structure at the cellular, circuit, and organ-wide scale is important for understanding physiological and biological functions. A bio-electrochemical technique known as CLARITY used for three...

    Authors: Hyunsu Lee, Jae-Hyung Park, Incheol Seo, Sun-Hyun Park and Shin Kim

    Citation: BMC Developmental Biology 2014 14:48

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  29. Content type: Research article

    Identification and characterization of molecular controls that regulate mammary stem and progenitor cell homeostasis are critical to our understanding of normal mammary gland development and its pathology.

    Authors: Gautam K Malhotra, Xiangshan Zhao, Emily Edwards, Janel L Kopp, Mayumi Naramura, Maike Sander, Hamid Band and Vimla Band

    Citation: BMC Developmental Biology 2014 14:47

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  30. Content type: Research article

    In standard cell division, the cells undergo karyokinesis and then cytokinesis. Some cells, however, such as cardiomyocytes and hepatocytes, can produce binucleate cells by going through mitosis without cytoki...

    Authors: Kiichiro Taniguchi, Akihiko Kokuryo, Takao Imano, Ryunosuke Minami, Hideki Nakagoshi and Takashi Adachi-Yamada

    Citation: BMC Developmental Biology 2014 14:46

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  31. Content type: Research article

    The development of the craniofacial skeleton from embryonic mesenchyme is a complex process that is not yet completely understood, particularly for intramembranous bones. This study investigates the developmen...

    Authors: Carolyn T Chang and Tamara Anne Franz-Odendaal

    Citation: BMC Developmental Biology 2014 14:44

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  32. Content type: Research article

    The mechanistic target of rapamycin complex1 (mTORC1) signaling pathway has been implicated in functions of multicellular processes, including cell growth and metabolism. Although recent reports showed that ma...

    Authors: Kentaro Hirose, Taishi Shiomi, Shunya Hozumi and Yutaka Kikuchi

    Citation: BMC Developmental Biology 2014 14:42

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  33. Content type: Research article

    The homeodomain transcription factor orthopedia (Otp) is an evolutionarily conserved regulator of neuronal fates. In vertebrates, Otp is necessary for the proper development of different regions of the brain a...

    Authors: Jose Arturo Gutierrez-Triana, Ulrich Herget, Patrick Lichtner, Luis A Castillo-Ramírez and Soojin Ryu

    Citation: BMC Developmental Biology 2014 14:41

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  34. Content type: Research article

    The sub-cortical maternal complex (SCMC), located in the subcortex of mouse oocytes and preimplantation embryos, is composed of at least four proteins encoded by maternal effect genes: OOEP, NLRP5/MATER, TLE6 ...

    Authors: Daniela Bebbere, Federica Ariu, Luisa Bogliolo, Laura Masala, Ombretta Murrone, Mauro Fattorini, Laura Falchi and Sergio Ledda

    Citation: BMC Developmental Biology 2014 14:40

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  35. Content type: Research article

    The switch from cartilage template to bone during endochondral ossification of the growth plate requires a dynamic and close interaction between cartilage and the developing vasculature. Vascular invasion of t...

    Authors: Sonja M Walzer, Erdal Cetin, Ruth Grübl-Barabas, Irene Sulzbacher, Beate Rueger, Werner Girsch, Stefan Toegel, Reinhard Windhager and Michael B Fischer

    Citation: BMC Developmental Biology 2014 14:36

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  36. Content type: Research article

    Members of the Semaphorin 3 family (Sema3s) influence the development of the central nervous system, and some are implicated in regulating aspects of visual system development. However, we lack information abo...

    Authors: Anil Sharma, Chrisna J LeVaillant, Giles W Plant and Alan R Harvey

    Citation: BMC Developmental Biology 2014 14:34

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    The Erratum to this article has been published in BMC Developmental Biology 2014 14:39

  37. Content type: Research article

    The 14-3-3 (YWHA) proteins are highly conserved in higher eukaryotes, participate in various cellular signaling pathways including cell cycle regulation, development and growth. Our previous studies demonstrat...

    Authors: Cheng Cui, Xiuli Ren, Dajun Liu, Xin Deng, Xin Qin, Xiangyu Zhao, Enhua Wang and Bingzhi Yu

    Citation: BMC Developmental Biology 2014 14:33

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  38. Content type: Research article

    To gain insight into what differences might restrict the capacity for limb regeneration in Xenopus froglets, we used High Performance Liquid Chromatography (HPLC)/double mass spectrometry to characterize protein ...

    Authors: Nandini Rao, Fengyu Song, Deepali Jhamb, Mu Wang, Derek J Milner, Nathaniel M Price, Teri L Belecky-Adams, Mathew J Palakal, Jo Ann Cameron, Bingbing Li, Xiaoping Chen and David L Stocum

    Citation: BMC Developmental Biology 2014 14:32

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  39. Content type: Methodology article

    Morphometric quantification of subtle craniofacial variation in studies of experimentally modified embryonic mice has proved valuable in determining the effects of developmental perturbations on craniofacial m...

    Authors: Christopher J Percival, Rebecca Green, Ralph Marcucio and Benedikt Hallgrímsson

    Citation: BMC Developmental Biology 2014 14:31

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  40. Content type: Research article

    Histone deacetylases (HDACs) play important roles in glial cell development and in disease states within multiple regions of the central nervous system. However, little is known about HDAC expression or functi...

    Authors: Sarika Tiwari, Subramanian Dharmarajan, Mahesh Shivanna, Deborah C Otteson and Teri L Belecky-Adams

    Citation: BMC Developmental Biology 2014 14:30

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  41. Content type: Research article

    The retinal pigmented epithelium (RPE) is a rounded shaped structure in almost all lizards. In the New World dwarf geckos, this structure shows an unusual morphology. In addition to this ocular character, we d...

    Authors: Ricardo A Guerra-Fuentes, Juan D Daza and Aaron M Bauer

    Citation: BMC Developmental Biology 2014 14:29

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  42. Content type: Research article

    Dimethyl sulfoxide (DMSO) is used extensively as a permeable cryoprotectant and is a common solvent utilized for several water-insoluble substances. DMSO has various biological and pharmacological activities; ...

    Authors: Dongjie Zhou, Xinghui Shen, Yanli Gu, Na Zhang, Tong Li, Xi Wu and Lei Lei

    Citation: BMC Developmental Biology 2014 14:28

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