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  1. Content type: Research article

    The use of Specific Pathogen Free (SPF) eggs in combination with RCAS retrovirus, a member of the Avian Sarcoma-Leukosis Virus (ASLV) family, is of standard practice to study gene function and development. SPF...

    Authors: Minda M McNally, Karl J Wahlin and M Valeria Canto-Soler

    Citation: BMC Developmental Biology 2010 10:106

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  2. Content type: Research article

    Vertebrate limb development involves a reciprocal feedback loop between limb mesenchyme and the overlying apical ectodermal ridge (AER). Several gene pathways participate in this feedback loop, including Fgf s...

    Authors: Troy Camarata, Diana Snyder, Tyler Schwend, Julian Klosowiak, Brandon Holtrup and Hans-Georg Simon

    Citation: BMC Developmental Biology 2010 10:104

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  3. Content type: Research article

    The vestibular system provides the primary input of our sense of balance and spatial orientation. Dysfunction of the vestibular system can severely affect a person's quality of life. Therefore, understanding t...

    Authors: Carla Sciarretta, Bernd Fritzsch, Kirk Beisel, Sonia M Rocha-Sanchez, Annalisa Buniello, Jacqueline M Horn and Liliana Minichiello

    Citation: BMC Developmental Biology 2010 10:103

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  4. Content type: Research article

    The p53 protein family coordinates stress responses of cells and organisms. Alternative promoter usage and/or splicing of p53 mRNA gives rise to at least nine mammalian p53 proteins with distinct N- and C-term...

    Authors: William R Davidson, Csaba Kari, Qing Ren, Borbala Daroczi, Adam P Dicker and Ulrich Rodeck

    Citation: BMC Developmental Biology 2010 10:102

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  5. Content type: Methodology article

    Tracing cell dynamics in the embryo becomes tremendously difficult when cell trajectories cross in space and time and tissue density obscure individual cell borders. Here, we used the chick neural crest (NC) a...

    Authors: Paul M Kulesa, Jessica M Teddy, Miranda Smith, Richard Alexander, Cameron HJ Cooper, Rusty Lansford and Rebecca McLennan

    Citation: BMC Developmental Biology 2010 10:101

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  6. Content type: Research article

    The Dmbx1 gene is important for the development of the midbrain and hindbrain, and mouse gene targeting experiments reveal that this gene is required for mediating postnatal and adult feeding behaviours. A single...

    Authors: Loksum Wong, Cameron J Weadick, Claire Kuo, Belinda SW Chang and Vincent Tropepe

    Citation: BMC Developmental Biology 2010 10:100

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  7. Content type: Research article

    Essential for mitotic growth 1 (EMG1) is a highly conserved nucleolar protein identified in yeast to have a critical function in ribosome biogenesis. A mutation in the human EMG1 homolog causes Bowen-Conradi s...

    Authors: Xiaoli Wu, Sumit Sandhu, Nehal Patel, Barbara Triggs-Raine and Hao Ding

    Citation: BMC Developmental Biology 2010 10:99

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  8. Content type: Research article

    Functional and molecular integrity of cardiomyocytes (CMs) derived from induced pluripotent stem (iPS) cells is essential for their use in tissue repair, disease modelling and drug screening. In this study we ...

    Authors: Manoj K Gupta, Damir J Illich, Andrea Gaarz, Matthias Matzkies, Filomain Nguemo, Kurt Pfannkuche, Huamin Liang, Sabine Classen, Michael Reppel, Joachim L Schultze, Jürgen Hescheler and Tomo Šarić

    Citation: BMC Developmental Biology 2010 10:98

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  9. Content type: Research article

    Embryonic morphogenesis of vascular and muscular systems is tightly coordinated, and a functional cooperation of Mtmr8 with PI3K in actin filament modeling and muscle development has been revealed in zebrafish...

    Authors: Jie Mei, Sha Liu, Zhi Li and Jian-Fang Gui

    Citation: BMC Developmental Biology 2010 10:96

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  10. Content type: Research article

    Conditional gene activation is an efficient strategy for studying gene function in genetically modified animals. Among the presently available gene switches, the tetracycline-regulated system has attracted con...

    Authors: Simone Wörtge, Leonid Eshkind, Nina Cabezas-Wallscheid, Bernard Lakaye, Jinhyun Kim, Rosario Heck, Yasmin Abassi, Mustafa Diken, Rolf Sprengel and Ernesto Bockamp

    Citation: BMC Developmental Biology 2010 10:95

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  11. Content type: Research article

    Regeneration is the ability of an organism to rebuild a body part that has been damaged or amputated, and can be studied at the molecular level using model organisms. Drosophila imaginal discs, which are the larv...

    Authors: Enrique Blanco, Marina Ruiz-Romero, Sergi Beltran, Manel Bosch, Adrià Punset, Florenci Serras and Montserrat Corominas

    Citation: BMC Developmental Biology 2010 10:94

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  12. Content type: Research article

    Development of the secondary palate (SP) is a complex event and abnormalities during SP development can lead to cleft palate, one of the most common birth disorders. Matrix metalloproteinases (MMPs) are requir...

    Authors: Graham D Brown and Adil J Nazarali

    Citation: BMC Developmental Biology 2010 10:93

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  13. Content type: Research article

    The protective external cuticle of insects does not accommodate growth during development. To compensate for this, the insect life cycle is punctuated by a series of molts. During the molt, a new and larger cu...

    Authors: Brandon J Loveall and David L Deitcher

    Citation: BMC Developmental Biology 2010 10:92

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  14. Content type: Research article

    Cells of the epithelially organised dermomyotome are traditionally believed to give rise to skeletal muscle and dermis. We have previously shown that the dermomyotome can undergo epithelial-mesenchymal transit...

    Authors: Baigang Wang, Qin Pu, Raja De, Ketan Patel, Bodo Christ, Jörg Wilting and Ruijin Huang

    Citation: BMC Developmental Biology 2010 10:91

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  15. Content type: Research article

    Imbalances in X-linked gene dosage between the sexes are resolved by transcriptionally silencing one of two X-chromosomes in female cells of the early mammalian embryo. X-inactivation is triggered by expressio...

    Authors: Janice Y Ahn and Jeannie T Lee

    Citation: BMC Developmental Biology 2010 10:90

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  16. Content type: Research article

    Pax2;5;8 transcription factors play diverse roles in vertebrate and invertebrate organogenesis, including the development of the inner ear. Past research has suggested various cochlear defects and some vestibular...

    Authors: Maxime Bouchard, Dominique de Caprona, Meinrad Busslinger, Pinxian Xu and Bernd Fritzsch

    Citation: BMC Developmental Biology 2010 10:89

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  17. Content type: Research article

    Detailed knowledge of the molecular and cellular mechanisms that direct spatial and temporal gene expression in pre-implantation embryos is critical for understanding the control of the maternal-zygotic transi...

    Authors: Tung-Chou Tsai, William Lin, Shang-Hsun Yang, Winston TK Cheng, En-Hui Cheng, Maw-Sheng Lee, Kowit-Yu Chong and Chuan-Mu Chen

    Citation: BMC Developmental Biology 2010 10:88

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  18. Content type: Research article

    The planar cell polarity (PCP) signalling pathway is fundamental to a number of key developmental events, including initiation of neural tube closure. Disruption of the PCP pathway causes the severe neural tub...

    Authors: Anju Paudyal, Christine Damrau, Victoria L Patterson, Alexander Ermakov, Caroline Formstone, Zuzanna Lalanne, Sara Wells, Xiaowei Lu, Dominic P Norris, Charlotte H Dean, Deborah J Henderson and Jennifer N Murdoch

    Citation: BMC Developmental Biology 2010 10:87

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  19. Content type: Research article

    In Drosophila muscle cell fusion takes place both during the formation of the somatic mesoderm and the visceral mesoderm, giving rise to the skeletal muscles and the gut musculature respectively. The core process...

    Authors: Therese Eriksson, Gaurav Varshney, Pontus Aspenström and Ruth H Palmer

    Citation: BMC Developmental Biology 2010 10:86

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  20. Content type: Methodology article

    We recently developed a new method to induce human stem cells (hESCs) differentiation into hematopoietic progenitors by cell extract treatment. Here, we report an efficient strategy to generate erythroid proge...

    Authors: Yu-xiao Liu, Wen Yue, Lei Ji, Xue Nan and Xue-tao Pei

    Citation: BMC Developmental Biology 2010 10:85

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  21. Content type: Research article

    Developmental angiogenesis proceeds through multiple morphogenetic events including sprouting, intussusception, and pruning. Mice lacking the membrane-anchored metalloproteinase regulator Reck die in utero around...

    Authors: Ediriweera PS Chandana, Yasuhiro Maeda, Akihiko Ueda, Hiroshi Kiyonari, Naoko Oshima, Mako Yamamoto, Shunya Kondo, Junseo Oh, Rei Takahashi, Yoko Yoshida, Satoshi Kawashima, David B Alexander, Hitoshi Kitayama, Chiaki Takahashi, Yasuhiko Tabata, Tomoko Matsuzaki…

    Citation: BMC Developmental Biology 2010 10:84

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  22. Content type: Research article

    C. elegans TGF-β-like Sma/Mab signaling pathway regulates both body size and sensory ray patterning. Most of the components in this pathway were initially identified by genetic screens based on the small body phe...

    Authors: Yan-Fung Wong, Qing Sheng, Janet WL Chung, Jacky KF Chan and King L Chow

    Citation: BMC Developmental Biology 2010 10:82

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  23. Content type: Methodology article

    The use of lentiviruses to reprogram human somatic cells into induced pluripotent stem (iPS) cells could limit their therapeutic usefulness due to the integration of viral DNA sequences into the genome of the ...

    Authors: Karim Si-Tayeb, Fallon K Noto, Ana Sepac, Filip Sedlic, Zeljko J Bosnjak, John W Lough and Stephen A Duncan

    Citation: BMC Developmental Biology 2010 10:81

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  24. Content type: Research article

    Patterning along the anterior-posterior (A-P) axis in Drosophila embryos is instructed by the morphogen gradient of Bicoid (Bcd). Despite extensive studies of this morphogen, how embryo geometry may affect gradie...

    Authors: Feng He, Ying Wen, David Cheung, Jingyuan Deng, Long J Lu, Renjie Jiao and Jun Ma

    Citation: BMC Developmental Biology 2010 10:80

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  25. Content type: Research article

    Hox genes play a central role in axial patterning during animal development. They are clustered in the genome and specify cell fate in sequential domains along the anteroposterior (A-P) body axis in a conserved o...

    Authors: Borbála Tihanyi, Tibor Vellai, Ágnes Regős, Eszter Ari, Fritz Müller and Krisztina Takács-Vellai

    Citation: BMC Developmental Biology 2010 10:78

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  26. Content type: Research article

    Thrombopoietin (Thpo) and its receptor (Mpl), which regulate megakaryopoiesis, are expressed in the central nervous system (CNS), where Thpo is thought to exert pro-apoptotic effects on newly generated neurons...

    Authors: Anna Ivanova, Jens Wuerfel, Juan Zhang, Olaf Hoffmann, Matthias Ballmaier and Christof Dame

    Citation: BMC Developmental Biology 2010 10:77

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  27. Content type: Research article

    Development and maintenance of the blood-brain and blood-retinal barrier is critical for the homeostasis of brain and retinal tissue. Despite decades of research our knowledge of the formation and maintenance ...

    Authors: Jing Xie, Eric Farage, Masahiko Sugimoto and Bela Anand-Apte

    Citation: BMC Developmental Biology 2010 10:76

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  28. Content type: Research article

    Presence of all three ParaHox genes has been described in deuterostomes and lophotrochozoans, but to date one of these three genes, Xlox has not been reported from any ecdysozoan taxa and both Xlox and Gsx are ab...

    Authors: Leyli Samadi and Gerhard Steiner

    Citation: BMC Developmental Biology 2010 10:74

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  29. Content type: Research article

    Male Irs2-/- mice develop fatal type 2 diabetes at 13-14 weeks. Defects in neuronal proliferation, pituitary development and photoreceptor cell survival manifest in Irs2-/- mice. We identify retarded renal growth...

    Authors: Rosemarie M Carew, Marianna Sadagurski, Roel Goldschmeding, Finian Martin, Morris F White and Derek P Brazil

    Citation: BMC Developmental Biology 2010 10:73

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  30. Content type: Research article

    Inhibitors-of-Apoptosis-Proteins (IAPs) are an evolutionarily conserved family of proteins capable of regulating several facets of apoptosis. IAPs are frequently dysregulated in cancer, but their role in the r...

    Authors: Thomas W Owens, Fiona M Foster, Jolanta Tanianis-Hughes, Julia Y Cheung, Lisa Brackenbury and Charles H Streuli

    Citation: BMC Developmental Biology 2010 10:71

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  31. Content type: Research article

    In vivo studies demonstrate that the Prox1 transcription factor plays a critical role in the development of the early lymphatic system. Upon Prox1 expression, early lymphatic endothelial cells differentiate from ...

    Authors: Harold Kim, Vicky PKH Nguyen, Tatiana V Petrova, Maribelle Cruz, Kari Alitalo and Daniel J Dumont

    Citation: BMC Developmental Biology 2010 10:72

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  32. Content type: Research article

    It is well established that the immature myocardium preferentially utilises non-oxidative energy-generating pathways. It exhibits low energy-transfer capacity via the creatine kinase (CK) shuttle, reflected in...

    Authors: Alexandra Fischer, Michiel ten Hove, Liam Sebag-Montefiore, Helga Wagner, Kieran Clarke, Hugh Watkins, Craig A Lygate and Stefan Neubauer

    Citation: BMC Developmental Biology 2010 10:70

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  33. Content type: Research article

    Mammals and Drosophila melanogaster share some striking similarities in spermatogenesis. Mitochondria in spermatids undergo dramatic morphological changes and syncytial spermatids are stripped from their cytoplas...

    Authors: Christoph Metzendorf and Maria I Lind

    Citation: BMC Developmental Biology 2010 10:68

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  34. Content type: Research article

    Transforming growth factor β proteins (Tgfβs) are secreted cytokines with well-defined functions in the differentiation of the musculoskeletal system of the developing limb. Here we have studied in chicken emb...

    Authors: Carlos I Lorda-Diez, Juan A Montero, Juan A Garcia-Porrero and Juan M Hurle

    Citation: BMC Developmental Biology 2010 10:69

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  35. Content type: Research article

    Outer dense fiber protein 2, Odf2, is a major component of the outer dense fibers, ODF, in the flagellum of spermatozoa. ODF are associated with microtubule doublets that form the axoneme. We recently demonstr...

    Authors: Heide Tarnasky, Min Cheng, Young Ou, Jacob C Thundathil, Richard Oko and Frans A van der Hoorn

    Citation: BMC Developmental Biology 2010 10:67

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  36. Content type: Research article

    In metazoans, the hematopoietic system plays a key role both in normal development and in defense of the organism. In Drosophila, the cellular immune response involves three types of blood cells: plasmatocytes...

    Authors: Amélie Avet-Rochex, Karène Boyer, Cédric Polesello, Vanessa Gobert, Dani Osman, Fernando Roch, Benoit Augé, Jennifer Zanet, Marc Haenlin and Lucas Waltzer

    Citation: BMC Developmental Biology 2010 10:65

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  37. Content type: Research article

    The synthesis of microRNA (miRNA) is a multi-step process that requires the action of the ribonuclease Dicer1. Dicer1 is responsible for the final processing of miRNA and has been implicated in cellular proces...

    Authors: Chen-Che J Huang and Humphrey HC Yao

    Citation: BMC Developmental Biology 2010 10:66

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  38. Content type: Research article

    Nuclear transfer has the potential to become one strategy for fish genetic resources management, by allowing fish reconstruction from cryopreserved somatic cells. Survival rates after nuclear transfer are stil...

    Authors: Pierre-Yves Le Bail, Alexandra Depince, Nathalie Chenais, Sophie Mahe, Gerard Maisse and Catherine Labbe

    Citation: BMC Developmental Biology 2010 10:64

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  39. Content type: Research article

    Caste differentiation in social insects is a type of polyphenism that enables division of labor among members of a colony. This elaborate social integration has attracted broad interest, although little is kno...

    Authors: Shigeyuki Koshikawa, Richard Cornette, Tadao Matsumoto and Toru Miura

    Citation: BMC Developmental Biology 2010 10:63

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  40. Content type: Research article

    Bone morphogenetic proteins (BMPs) are members of the conserved transforming growth factor β (TGFβ superfamily, and play many developmental and homeostatic roles. In C. elegans, a BMP-like pathway, the DBL-1 path...

    Authors: Andrew F Roberts, Tina L Gumienny, Ryan J Gleason, Huang Wang and Richard W Padgett

    Citation: BMC Developmental Biology 2010 10:61

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  41. Content type: Research article

    Articular cartilage (AC) is the layer of tissue that covers the articulating ends of the bones in diarthrodial joints. Across species, adult AC shows an arcade-like structure with collagen predominantly perpen...

    Authors: Mark C van Turnhout, Henk Schipper, Bas Engel, Willem Buist, Sander Kranenbarg and Johan L van Leeuwen

    Citation: BMC Developmental Biology 2010 10:62

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  42. Content type: Methodology article

    To maintain pluripotency of human embryonic stem (huES) cells in feeder-free culture it has been necessary to provide a Matrigel substratum, which is a complex of poorly defined extracellular matrices and grow...

    Authors: Masato Nagaoka, Karim Si-Tayeb, Toshihiro Akaike and Stephen A Duncan

    Citation: BMC Developmental Biology 2010 10:60

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  43. Content type: Research article

    Copines are calcium-dependent phospholipid-binding proteins found in diverse eukaryotic organisms. We are studying the function of copines in Dictyostelium discoideum, a single-celled amoeba that undergoes cell d...

    Authors: Tasha S Smith, Jaimie M Pineda, Alex C Donaghy and Cynthia K Damer

    Citation: BMC Developmental Biology 2010 10:59

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  44. Content type: Research article

    The development of teeth is the result of interactions between competent mesenchyme and epithelium, both of which undergo extensive morphogenesis. The importance of cell adhesion molecules in morphogenesis has...

    Authors: Barbara Verstraeten, Ellen Sanders, Jolanda van Hengel and Ann Huysseune

    Citation: BMC Developmental Biology 2010 10:58

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  45. Content type: Research article

    Our understanding of the mechanisms that protect the developing embryo from intrauterine stress is limited. Recently, adenosine has been demonstrated to play a critical role in protecting the embryo against hy...

    Authors: Christopher C Wendler, Ryan R Poulsen, Satish Ghatpande, Robert W Greene and Scott A Rivkees

    Citation: BMC Developmental Biology 2010 10:57

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  46. Content type: Research article

    Three kidney systems appear during vertebrate development: the pronephroi, mesonephroi and metanephroi. The pronephric duct is the first or primary ureter of these kidney systems. Its role as a key player in t...

    Authors: Birgitte M Haugan, Kenneth A Halberg, Åse Jespersen, Lea R Prehn and Nadja Møbjerg

    Citation: BMC Developmental Biology 2010 10:56

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