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  1. It has been suggested that the ectopic expression of PDX1, a dominant pancreatic transcription factor, plays a critical role in the developmental programming of the pancreas even from cells of unrelated tissue...

    Authors: Shruti Balaji, Yu Zhou, Anasuya Ganguly, Emmanuel C. Opara and Shay Soker

    Citation: BMC Developmental Biology 2016 16:8

    Content type: Research article

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  2. Akt (PKB) is a serine threonine protein kinase downstream of the phosphoinositide 3-kinase (PI3K) pathway. In mammals, Akt is ubiquitously expressed and is associated with regulation of cellular proliferation,...

    Authors: T. Harshani Peiris, Daniel Ramirez, Paul G. Barghouth and Néstor J. Oviedo

    Citation: BMC Developmental Biology 2016 16:7

    Content type: Research article

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  3. Time-lapse imaging has proven highly valuable for studying development, yielding data of much finer resolution than traditional “still-shot” studies and allowing direct examination of tissue and cell dynamics....

    Authors: Eduardo E. Zattara, Kate W. Turlington and Alexandra E. Bely

    Citation: BMC Developmental Biology 2016 16:6

    Content type: Methodology article

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  4. Microenvironments called niches maintain resident stem cell populations by balancing self-renewal with differentiation, but the genetic regulation of this process is unclear. The niche of the Drosophila testis...

    Authors: Amanda J. Monahan and Michelle Starz-Gaiano

    Citation: BMC Developmental Biology 2016 16:5

    Content type: Research article

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  5. The Hedgehog (Hh) signaling pathway, acting through three homologous transcription factors (GLI1, GLI2, GLI3) in vertebrates, plays multiple roles in embryonic organ development and adult tissue homeostasis. A...

    Authors: Katherine Gurdziel, Kyle R. Vogt, Gary Schneider, Neil Richards and Deborah L. Gumucio

    Citation: BMC Developmental Biology 2016 16:4

    Content type: Research article

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  6. The correct evaluation of mineralization is fundamental for the study of skeletal development, maintenance, and regeneration. Current methods to visualize mineralized tissue in zebrafish rely on: 1) fixed spec...

    Authors: A. Bensimon-Brito, J. Cardeira, G. Dionísio, A. Huysseune, M. L. Cancela and P. E. Witten

    Citation: BMC Developmental Biology 2016 16:2

    Content type: Methodology article

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  7. Bone morphogenetic proteins regulate multiple processes in embryonic development, including early dorso-ventral patterning and neural crest development. BMPs activate heteromeric receptor complexes consisting ...

    Authors: Carolin Schille, Jens Heller and Alexandra Schambony

    Citation: BMC Developmental Biology 2016 16:1

    Content type: Research article

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  8. It has been found that microRNAs (miRNAs) play important roles in the regulation of tooth development, and most likely increase the complexity of the genetic network, thus lead to greater complexity of teeth. ...

    Authors: Ang Li, Ye Li, Tieli Song, Fu Wang, Dayong Liu, Zhipeng Fan, San Cheng, Chunmei Zhang, Jinsong Wang, Junqi He and Songlin Wang

    Citation: BMC Developmental Biology 2015 15:51

    Content type: Research article

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  9. The vertebrate heart consists of three cell layers: the innermost endothelium, the contractile myocardium and the outermost epicardium. The epicardium is vital for heart development and function, and forms fro...

    Authors: Monica S. Yue, Jessica S. Plavicki, Xin-yi Li, Richard E. Peterson and Warren Heideman

    Citation: BMC Developmental Biology 2015 15:50

    Content type: Methodology article

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  10. This study describes the generation and analysis of the transcriptional profile of bovine inner cell mass (ICM) and trophectoderm (TE), obtained from in vivo developed embryos by using a bovine-embryo specific...

    Authors: S. M. Hosseini, I. Dufort, J. Caballero, F. Moulavi, H. R. Ghanaei and M. A. Sirard

    Citation: BMC Developmental Biology 2015 15:49

    Content type: Research article

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  11. Salamanders regenerate their tails after amputation anywhere along their length. How the system faithfully reconstitutes the original number of segments and length is not yet known.

    Authors: Carr D. Vincent, Fabian Rost, Wouter Masselink, Lutz Brusch and Elly M. Tanaka

    Citation: BMC Developmental Biology 2015 15:48

    Content type: Research article

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  12. Biliary atresia (BA) is a human infant disease with inflammatory fibrous obstructions in the bile ducts and is the most common cause for pediatric liver transplantation. In contrast, the sea lamprey undergoes ...

    Authors: Yu-Wen Chung-Davidson, Chu-Yin Yeh, Ugo Bussy, Ke Li, Peter J. Davidson, Kaben G. Nanlohy, C. Titus Brown, Steven Whyard and Weiming Li

    Citation: BMC Developmental Biology 2015 15:47

    Content type: Research article

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  13. Super-resolution fluorescence microscopy performed via 3D structured illumination microscopy (3D-SIM) is well established on flat, adherent cells. However, blastomeres of mammalian embryos are non-adherent, ro...

    Authors: Jens Popken, Maik Dahlhoff, Tuna Guengoer, Eckhard Wolf and Valeri Zakhartchenko

    Citation: BMC Developmental Biology 2015 15:46

    Content type: Methodology article

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  14. The endogenous ability to dedifferentiate, re-pattern, and re-differentiate adult cells to repair or replace damaged or missing structures is exclusive to only a few tetrapod species. The Mexican axolotl is on...

    Authors: Catherine D. McCusker, Antony Athippozhy, Carlos Diaz-Castillo, Charless Fowlkes, David M. Gardiner and S. Randal Voss

    Citation: BMC Developmental Biology 2015 15:45

    Content type: Research article

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  15. Acute kidney injury in mammals, which is caused by cardiovascular diseases or the administration of antibiotics with nephrotoxic side-effects is a life-threatening disease, since loss of nephrons is irreversib...

    Authors: Beate Hoppe, Stefan Pietsch, Martin Franke, Sven Engel, Marco Groth, Matthias Platzer and Christoph Englert

    Citation: BMC Developmental Biology 2015 15:43

    Content type: Research article

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  16. The investigation of skeletal muscle development is of importance in stock farming and biomedicine. It is still ambiguous that whether animals are born with the full set of skeletal muscle fibers or if the num...

    Authors: Mingsen Li, Xingyu Zhou, Yaosheng Chen, Yaping Nie, Huaxing Huang, Hu Chen and Delin Mo

    Citation: BMC Developmental Biology 2015 15:42

    Content type: Research article

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  17. TALE-class homeodomain transcription factors Meis and Pbx play important roles in formation of the embryonic brain, eye, heart, cartilage or hematopoiesis. Loss-of-function studies of Pbx1, 2 and 3 and Meis1 d...

    Authors: Ondrej Machon, Jan Masek, Olga Machonova, Stefan Krauss and Zbynek Kozmik

    Citation: BMC Developmental Biology 2015 15:40

    Content type: Research article

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  18. Components of the limb musculoskeletal system have distinct mesoderm origins. Limb skeletal muscles originate from somites, while the skeleton and attachments (tendons and connective tissues) derive from limb ...

    Authors: Adeline Bourgeois, Joana Esteves de Lima, Benjamin Charvet, Koichi Kawakami, Sigmar Stricker and Delphine Duprez

    Citation: BMC Developmental Biology 2015 15:39

    Content type: Methodology article

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  19. The GATA-binding factor 6 (Gata6) gene encodes a zinc finger transcription factor that often functions as a key regulator of lineage specification during development. It is the earliest known marker of the primit...

    Authors: Laina Freyer, Christian Schröter, Néstor Saiz, Nadine Schrode, Sonja Nowotschin, Alfonso Martinez-Arias and Anna-Katerina Hadjantonakis

    Citation: BMC Developmental Biology 2015 15:38

    Content type: Methodology article

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  20. Primitive endoderm is a cell lineage segregated from the epiblast in the blastocyst and gives rise to parietal and visceral endoderm. Sox7 is a member of the SoxF gene family that is specifically expressed in pri...

    Authors: Masaki Kinoshita, Daisuke Shimosato, Mariko Yamane and Hitoshi Niwa

    Citation: BMC Developmental Biology 2015 15:37

    Content type: Research article

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  21. Development of the valves and septa of the heart depends on the formation and remodeling of the endocardial cushions in the atrioventricular canal and outflow tract. These cushions are populated by mesenchyme ...

    Authors: Ryan J. Coram, Samantha J. Stillwagon, Anuradha Guggilam, Michael W. Jenkins, Maurice S. Swanson and Andrea N. Ladd

    Citation: BMC Developmental Biology 2015 15:36

    Content type: Research article

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  22. Pluripotent cells are present in early embryos until the levels of the pluripotency regulator Oct4 drop at the beginning of somitogenesis. Elevating Oct4 levels in explanted post-pluripotent cells in vitro res...

    Authors: Constantinos Economou, Anestis Tsakiridis, Filip J. Wymeersch, Sabrina Gordon-Keylock, Robert E Dewhurst, Dawn Fisher, Alexander Medvinsky, Andrew JH Smith and Valerie Wilson

    Citation: BMC Developmental Biology 2015 15:35

    Content type: Research article

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  23. Sex determination in mammals requires expression of the Y-linked gene Sry in the bipotential genital ridges of the XY embryo. Even minor delay of the onset of Sry expression can result in XY sex reversal, highlig...

    Authors: Christian Larney, Timothy L. Bailey and Peter Koopman

    Citation: BMC Developmental Biology 2015 15:34

    Content type: Research article

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  24. In multiple vertebrate organisms, including chick, Xenopus, and zebrafish, Fibroblast Growth Factor (FGF) and Wnt signaling cooperate during formation of the otic placode. However, in the mouse, although FGF sign...

    Authors: Kevin D. Wright, Amanda A. Mahoney Rogers, Jian Zhang and Katherine Shim

    Citation: BMC Developmental Biology 2015 15:33

    Content type: Research article

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  25. Recent studies have identified epithelial stem and progenitor cell populations of the lung. We are just beginning to understand the mechanisms that regulate their homeostatic, regenerative and maladaptive beha...

    Authors: Matt L. Donne, Andrew J. Lechner and Jason R. Rock

    Citation: BMC Developmental Biology 2015 15:32

    Content type: Commentary

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  26. It remains unclear to what extent midgut rotation determines human intestinal topography and pathology. We reinvestigated the midgut during its looping and herniation phases of development, using novel 3D visu...

    Authors: Jelly HM Soffers, Jill PJM Hikspoors, Hayelom K. Mekonen, S. Eleonore Koehler and Wouter H. Lamers

    Citation: BMC Developmental Biology 2015 15:31

    Content type: Research article

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  27. Nearly half of all individuals with Down Syndrome (DS) have some type of congenital heart defect (CHD), suggesting that DS sensitizes to CHD but does not cause it. We used a common mouse model of DS, the Ts65D...

    Authors: Renita C. Polk, Peter Gergics, Jeffrey D. Steimle, Huiqing Li, Ivan P. Moskowitz, Sally A. Camper and Roger H. Reeves

    Citation: BMC Developmental Biology 2015 15:30

    Content type: Research article

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  28. Magnetic resonance imaging (MRI) has many advantages in the research of in vivo embryonic brain development, specifically its noninvasive aspects and ability to avoid skeletal interference. However, few studie...

    Authors: Zien Zhou, Zengai Chen, Jiehui Shan, Weiwei Ma, Lei Li, Jinyan Zu and Jianrong Xu

    Citation: BMC Developmental Biology 2015 15:29

    Content type: Research article

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  29. Haploinsufficiency of the FOXL2 transcription factor in humans causes Blepharophimosis/Ptosis/Epicanthus Inversus syndrome (BPES), characterized by eyelid anomalies and premature ovarian failure. Mice lacking Fox...

    Authors: Mara Marongiu, Loredana Marcia, Emanuele Pelosi, Mario Lovicu, Manila Deiana, Yonqing Zhang, Alessandro Puddu, Angela Loi, Manuela Uda, Antonino Forabosco, David Schlessinger and Laura Crisponi

    Citation: BMC Developmental Biology 2015 15:27

    Content type: Research article

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  30. During the fourth larval (L4) stage, vulval cells of C. elegans undergo extensive morphogenesis accompanied by changes in gene expression. This phase of vulval development, occurring after the well-studied induct...

    Authors: Darren Z. L. Mok, Paul W. Sternberg and Takao Inoue

    Citation: BMC Developmental Biology 2015 15:26

    Content type: Methodology article

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  31. MicroRNAs (miRNAs) are small noncoding RNAs that act as post-transcriptional regulators of gene targets. Accurate quantification of miRNA expression using validated internal controls should aid in the understa...

    Authors: Mahdi Mahdipour, Helena T.A. van Tol, Tom A.E. Stout and Bernard A.J. Roelen

    Citation: BMC Developmental Biology 2015 15:25

    Content type: Research article

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  32. Adult echinoderms can completely regenerate major parts of their central nervous system even after severe injuries. Even though this capacity has long been known, the molecular mechanisms that drive fast and c...

    Authors: Vladimir S Mashanov, Olga R Zueva and José E García-Arrarás

    Citation: BMC Developmental Biology 2015 15:24

    Content type: Research Article

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  33. HP1γ, a well-known regulator of gene expression, has been recently identified to be a target of Aurora A, a mitotic kinase which is important for both gametogenesis and embryogenesis. The purpose of this study...

    Authors: Phoebe H. Leonard, Adrienne Grzenda, Angela Mathison, Dean E. Morbeck, Jolene R. Fredrickson, Thiago M. de Assuncao, Trace Christensen, Jeffrey Salisbury, Ezequiel Calvo, Juan Iovanna, Charles C. Coddington, Raul Urrutia and Gwen Lomberk

    Citation: BMC Developmental Biology 2015 15:23

    Content type: Research article

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  34. Despite extensive knowledge on bivalve anatomy and development, the formation and differentiation of the mantle margin and its associated organs remain largely unclear. Bivalves from the family Pectinidae (sca...

    Authors: Jorge A. Audino, José Eduardo A. R. Marian, Andreas Wanninger and Sônia G. B. C. Lopes

    Citation: BMC Developmental Biology 2015 15:22

    Content type: Research article

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  35. The mouse embryonic mandible comprises two types of tooth primordia in the cheek region: progressive tooth primordia of prospective functional teeth and rudimentary tooth primordia in premolar region – MS and ...

    Authors: Katerina Lochovska, Renata Peterkova, Zuzana Pavlikova and Maria Hovorakova

    Citation: BMC Developmental Biology 2015 15:21

    Content type: Research article

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  36. Endothelial or epithelial cellular branching is vital in development and cancer progression; however, the molecular mechanisms of these processes are not clear. In Drosophila, terminal cell at the end of some tra...

    Authors: Matthew Man-Kin Wong, Ming-Fai Liu and Sung Kay Chiu

    Citation: BMC Developmental Biology 2015 15:20

    Content type: Research article

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  37. The ability to visualise the expression of individual genes in situ is an invaluable tool for developmental and evolutionary biologists; it allows for the characterisation of gene function, gene regulation and th...

    Authors: Jennifer Hohagen, Ines Herlitze and Daniel John Jackson

    Citation: BMC Developmental Biology 2015 15:19

    Content type: Methodology article

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  38. The developing eye receives blood supply from two vascular systems, the intraocular hyaloid system and the superficial choroidal vessels. In zebrafish, a highly stereotypic and simple set of vessels develops o...

    Authors: Rivka Kaufman, Omri Weiss, Meyrav Sebbagh, Revital Ravid, Liron Gibbs-Bar, Karina Yaniv and Adi Inbal

    Citation: BMC Developmental Biology 2015 15:18

    Content type: Research article

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  39. Marsupials such as the tammar wallaby (M.Eugenii) have a short gestation (29.3 days) and at birth the altricial young resembles a fetus, and the major development occurs postnatally while the young remains in the...

    Authors: Vengamanaidu Modepalli, Lyn A Hinds, Julie A Sharp, Christophe Lefevre and Kevin R Nicholas

    Citation: BMC Developmental Biology 2015 15:16

    Content type: Research article

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  40. There is increasing evidence of a pivotal role for regulated mRNA translation in control of developmental cell fate transitions. Physiological and pathological stem and progenitor cell self-renewal is maintain...

    Authors: Angus M MacNicol, Linda L Hardy, Horace J Spencer and Melanie C MacNicol

    Citation: BMC Developmental Biology 2015 15:15

    Content type: Research article

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  41. Human dental pulp represents a suitable alternative source of stem cells for the purpose of cell-based therapies in regenerative medicine, because it is relatively easy to obtain it, using low invasive procedu...

    Authors: Alessandra Pisciotta, Gianluca Carnevale, Simona Meloni, Massimo Riccio, Sara De Biasi, Lara Gibellini, Adriano Ferrari, Giacomo Bruzzesi and Anto De Pol

    Citation: BMC Developmental Biology 2015 15:14

    Content type: Research article

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  42. In mammals, maternal differentially methylated regions (DMRs) acquire DNA methylation during the postnatal growth stage of oogenesis, with paternal DMRs acquiring DNA methylation in the perinatal prospermatago...

    Authors: Alan M O’Doherty, David A Magee, Lynee C O’Shea, Niamh Forde, Marijke E Beltman, Solomon Mamo and Trudee Fair

    Citation: BMC Developmental Biology 2015 15:13

    Content type: Research article

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  43. Central American crater lake cichlid fish of the Midas species complex (Amphilophus spp.) are a model system for sympatric speciation and fast ecological diversification and specialization. Midas cichlids have be...

    Authors: Claudius F Kratochwil, Maggie M Sefton and Axel Meyer

    Citation: BMC Developmental Biology 2015 15:12

    Content type: Research article

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  44. Tissue fixation is crucial for preserving the morphology of biological structures and cytological details to prevent postmortem degradation and autolysis. Improper fixation conditions could lead to artifacts a...

    Authors: Jing Nie, Simpla Mahato and Andrew C Zelhof

    Citation: BMC Developmental Biology 2015 15:10

    Content type: Methodology article

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