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  1. Content type: Research article

    Phosphatase of regenerating liver (PRL) family is classified as class IVa of protein tyrosine phosphatase (PTP4A) that removes phosphate groups from phosphorylated tyrosine residues on proteins. PRL phosphatas...

    Authors: Ming-Der Lin, Hsun-Tzu Lee, Szu-Chieh Wang, Han-Ru Li, Hsin-Lun Hsien, Kai-Wen Cheng, Yu-Di Chang, Min-Lang Huang, Jr-Kai Yu and Yau-Hung Chen

    Citation: BMC Developmental Biology 2013 13:18

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  2. Content type: Methodology article

    Molecular studies of appendage regeneration have been hindered by the lack of a stable and efficient means of transferring exogenous genes. We therefore sought an efficient integrating virus system that could ...

    Authors: Shahryar Khattak, Tatiana Sandoval-Guzmán, Nicole Stanke, Stephanie Protze, Elly M Tanaka and Dirk Lindemann

    Citation: BMC Developmental Biology 2013 13:17

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  3. Content type: Research article

    Protein kinase C epsilon (PKCϵ) belongs to the novel PKC subfamily, which consists of diacylglycerol dependent- and calcium independent-PKCs. Previous studies have shown that PKCϵ is important in different con...

    Authors: Sergio Carracedo, Ursula Braun and Michael Leitges

    Citation: BMC Developmental Biology 2013 13:16

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  4. Content type: Methodology article

    Live imaging provides an essential methodology for understanding complex and dynamic cell behaviors and their underlying molecular mechanisms. Genetically-encoded reporter expressing mouse strains are an impor...

    Authors: Sonja Nowotschin, Panagiotis Xenopoulos, Nadine Schrode and Anna-Katerina Hadjantonakis

    Citation: BMC Developmental Biology 2013 13:15

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  5. Content type: Research article

    The phoronid larva, which is called the actinotrocha, is one of the most remarkable planktotrophic larval types among marine invertebrates. Actinotrochs live in plankton for relatively long periods and undergo...

    Authors: Elena N Temereva and Eugeni B Tsitrin

    Citation: BMC Developmental Biology 2013 13:14

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  6. Content type: Research article

    MicroRNAs play important roles in regulating biological processes, including organ morphogenesis and maturation. However, little is known about specific pathways regulated by miRNA during lung development. Bet...

    Authors: Sana Mujahid, Tanya Logvinenko, MaryAnn V Volpe and Heber C Nielsen

    Citation: BMC Developmental Biology 2013 13:13

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  7. Content type: Research article

    Transcription factors from the MADS-box family play a relevant role in cell differentiation and development and include the animal SRF (serum response factor) and MEF2 (myocyte enhancer factor 2) proteins. The...

    Authors: María Galardi-Castilla, Irene Fernandez-Aguado, Teresa Suarez and Leandro Sastre

    Citation: BMC Developmental Biology 2013 13:12

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  8. Content type: Research article

    Our current knowledge on tooth development derives primarily from studies in mice. Very little is known about gene expression and function during human odontogenesis. Sonic Hedgehog (SHH) signaling has been de...

    Authors: Xuefeng Hu, Shuo Zhang, Guimiao Chen, Chensheng Lin, Zhen Huang, YiPing Chen and Yanding Zhang

    Citation: BMC Developmental Biology 2013 13:11

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  9. Content type: Research article

    The 14-3-3 (YWHA) proteins are central mediators in various cellular signaling pathways regulating development and growth, including cell cycle regulation. We previously reported that all seven mammalian 14-3-...

    Authors: Santanu De and Douglas Kline

    Citation: BMC Developmental Biology 2013 13:10

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    The Erratum to this article has been published in BMC Developmental Biology 2014 14:20

  10. Content type: Research article

    Tenm4 is a mouse homolog of the Drosophila gene Tenascin-m (Ten-m (Odd oz)), which functions in motor neuron routing. Recently, a genome-wide association analysis for bipolar disorder identified a new susceptibil...

    Authors: Hisashi Nakamura, Rita N Cook and Monica J Justice

    Citation: BMC Developmental Biology 2013 13:9

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  11. Content type: Methodology article

    The freshwater planarian Schmidtea mediterranea has emerged as a powerful model for studies of regenerative, stem cell, and germ cell biology. Whole-mount in situ hybridization (WISH) and whole-mount fluorescent

    Authors: Ryan S King and Phillip A Newmark

    Citation: BMC Developmental Biology 2013 13:8

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  12. Content type: Research article

    In the male germ line of Drosophila chromatin remains decondensed and highly transcribed during meiotic prophase until it is rapidly compacted. A large proportion of the cell cycle-regulated histone H3.1 is repla...

    Authors: Wolfgang Hennig and Alexandra Weyrich

    Citation: BMC Developmental Biology 2013 13:7

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  13. Content type: Reviewer acknowledgement

    The editors of BMC Developmental Biology would like to thank all our reviewers who have contributed to the journal in Volume 12 (2012).

    Authors: Philippa K Harris

    Citation: BMC Developmental Biology 2013 13:5

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  14. Content type: Research article

    Thyroid hormones regulate growth and development. However, the molecular mechanisms by which thyroid hormone regulates cell structural development are not fully understood. The mammalian cochlea is an intrigui...

    Authors: Katherine B Szarama, Núria Gavara, Ronald S Petralia, Richard S Chadwick and Matthew W Kelley

    Citation: BMC Developmental Biology 2013 13:6

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  15. Content type: Research article

    Individual skeletal elements of the vertebrate limbs arise through a segmentation process introducing joints in specific locations. However, the molecular pathways controlling joint formation and subsequent jo...

    Authors: Akinori Kan, Toshiyuki Ikeda, Atsushi Fukai, Takumi Nakagawa, Kozo Nakamura, Ung-il Chung, Hiroshi Kawaguchi and Clifford J Tabin

    Citation: BMC Developmental Biology 2013 13:4

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  16. Content type: Research article

    Insulin and its plasma membrane receptor constitute an ancient response system critical to cell growth and differentiation. Studies using intact Rana pipiens oocytes have shown that insulin can act at receptors o...

    Authors: Gene A Morrill, Adele B Kostellow, Richard D Moore and Raj K Gupta

    Citation: BMC Developmental Biology 2013 13:3

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  17. Content type: Research article

    The members of the protein kinase C (PKC) family consist of serine/threonine kinases classified according to their regulatory domain. Those that belong to the novel PKC subfamily, such as PKCδ, are dependent o...

    Authors: Sergio Carracedo, Ursula Braun and Michael Leitges

    Citation: BMC Developmental Biology 2013 13:2

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  18. Content type: Research article

    Group B Sox domain transcription factors play important roles in metazoan central nervous system development. They are, however, difficult to study as mutations often have pleiotropic effects and other Sox fam...

    Authors: Shih Pei Shen, Jelena Aleksic and Steven Russell

    Citation: BMC Developmental Biology 2013 13:1

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  19. Content type: Research article

    Members of the family Syngnathidae share a unique reproductive mode termed male pregnancy. Males carry eggs in specialised brooding structures for several weeks and release free-swimming offspring. Here we des...

    Authors: Stefan Sommer, Camilla M Whittington and Anthony B Wilson

    Citation: BMC Developmental Biology 2012 12:39

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  20. Content type: Methodology article

    Magnetic resonance imaging is a noninvasive method of evaluating embryonic development. Diffusion tensor imaging (DTI), based on the directional diffusivity of water molecules, is an established method of eval...

    Authors: Zien Zhou, Zachary DelProposto, Lianming Wu, Jianrong Xu, Jia Hua, Yan Zhou, Yongquan Ye, Zishu Zhang, Jiani Hu and E Mark Haacke

    Citation: BMC Developmental Biology 2012 12:38

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  21. Content type: Research article

    Genetic studies in mouse have demonstrated the crucial function of PAX4 in pancreatic cell differentiation. This transcription factor specifies β- and δ-cell fate at the expense of α-cell identity by repressing A...

    Authors: Joachim Djiotsa, Vincianne Verbruggen, Jean Giacomotto, Minaka Ishibashi, Elisabeth Manning, Silke Rinkwitz, Isabelle Manfroid, Marianne L Voz and Bernard Peers

    Citation: BMC Developmental Biology 2012 12:37

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  22. Content type: Research article

    In mammals, R-spondin (Rspo), an activator of the Wnt/β-catenin signaling pathway, has been shown to be involved in ovarian differentiation. However, the role of the Rspo/Wnt/β-catenin signaling pathway in fis...

    Authors: Linyan Zhou, Tapas Charkraborty, Xiangguo Yu, Limin Wu, Gang Liu, Sipra Mohapatra, Deshou Wang and Yoshitaka Nagahama

    Citation: BMC Developmental Biology 2012 12:36

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  23. Content type: Research article

    The proper balance of autophagy, a lysosome-mediated degradation process, is indispensable for oogenesis in Drosophila. We recently demonstrated that egg development depends on autophagy in the somatic follicle c...

    Authors: Julia MI Barth, Ernst Hafen and Katja Köhler

    Citation: BMC Developmental Biology 2012 12:35

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  24. Content type: Research article

    The contribution of cell proliferation to regeneration varies greatly between different metazoan models. Planarians rely on pluripotent neoblasts and amphibian limb regeneration depends upon formation of a pro...

    Authors: Yale J Passamaneck and Mark Q Martindale

    Citation: BMC Developmental Biology 2012 12:34

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  25. Content type: Research article

    The first distinct differentiation event in mammals occurs at the blastocyst stage when totipotent blastomeres differentiate into either pluripotent inner cell mass (ICM) or multipotent trophectoderm (TE). Her...

    Authors: Manabu Ozawa, Miki Sakatani, JiQiang Yao, Savita Shanker, Fahong Yu, Rui Yamashita, Shunichi Wakabayashi, Kenta Nakai, Kyle B Dobbs, Mateus José Sudano, William G Farmerie and Peter J Hansen

    Citation: BMC Developmental Biology 2012 12:33

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  26. Content type: Research article

    Temperature affects virtually all cellular processes. A quick increase in temperature challenges the cells to undergo a heat shock response to maintain cellular homeostasis. Heat shock factor-1 (HSF-1) functio...

    Authors: János Barna, Andrea Princz, Mónika Kosztelnik, Balázs Hargitai, Krisztina Takács-Vellai and Tibor Vellai

    Citation: BMC Developmental Biology 2012 12:32

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  27. Content type: Research article

    Oxygen sensing is a near universal signaling modality that, in eukaryotes ranging from protists such as Dictyostelium and Toxoplasma to humans, involves a cytoplasmic prolyl 4-hydroxylase that utilizes oxygen and...

    Authors: Yuechi Xu, Zhuo A Wang, Rebekah S Green and Christopher M West

    Citation: BMC Developmental Biology 2012 12:31

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  28. Content type: Research article

    Embryonic development proceeds through finely tuned reprogramming of the parental genomes to form a totipotent embryo. Cells within this embryo will then differentiate and give rise to all the tissues of a new...

    Authors: Tiphaine Aguirre-Lavin, Pierre Adenot, Amélie Bonnet-Garnier, Gaétan Lehmann, Renaud Fleurot, Claire Boulesteix, Pascale Debey and Nathalie Beaujean

    Citation: BMC Developmental Biology 2012 12:30

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  29. Content type: Research article

    Hox proteins are transcription factors involved in crucial processes during animal development. Their mode of action remains scantily documented. While other families of transcription factors, like Smad or Sta...

    Authors: Barbara Lambert, Julie Vandeputte, Sophie Remacle, Isabelle Bergiers, Nicolas Simonis, Jean-Claude Twizere, Marc Vidal and René Rezsohazy

    Citation: BMC Developmental Biology 2012 12:29

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  30. Content type: Research article

    In chondrichthyans, basal osteichthyans and tetrapods, vertebral bodies have cartilaginous anlagen that subsequently mineralize (chondrichthyans) or ossify (osteichthyans). Chondrocytes that form the vertebral...

    Authors: Anabela Bensimon-Brito, João Cardeira, Maria Leonor Cancela, Ann Huysseune and Paul Eckhard Witten

    Citation: BMC Developmental Biology 2012 12:28

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  31. Content type: Research article

    Secreted frizzled-related proteins (SFRPs) are a family of proteins that block the Wnt signaling pathway and loss of SFRP1 expression is found in breast cancer along with a multitude of other human cancers. Ac...

    Authors: Kelly J Gauger, Akihiko Shimono, Giovanna M Crisi and Sallie Smith Schneider

    Citation: BMC Developmental Biology 2012 12:25

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  32. Content type: Research article

    The multicellular slug in Dictyostelium has a single tip that acts as an organising centre patterning the rest of the slug. High adenosine levels at the tip are believed to be responsible for this tip dominance a...

    Authors: Pundrik Jaiswal, Shashi Prakash Singh, Prasad Aiyar, Rakhil Akkali and Ramamurthy Baskar

    Citation: BMC Developmental Biology 2012 12:26

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  33. Content type: Research article

    Zebrafish has emerged as a powerful model organism to study the process of regeneration. This teleost fish has the ability to regenerate various tissues and organs like the heart, spinal cord, retina and fins....

    Authors: Ana Sofia Azevedo, Sara Sousa, António Jacinto and Leonor Saúde

    Citation: BMC Developmental Biology 2012 12:24

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  34. Content type: Research article

    Mouse limb bud is a prime model to study the regulatory interactions that control vertebrate organogenesis. Major aspects of limb bud development are controlled by feedback loops that define a self-regulatory ...

    Authors: Aimée Zuniga, Frédéric Laurent, Javier Lopez-Rios, Christian Klasen, Nicolas Matt and Rolf Zeller

    Citation: BMC Developmental Biology 2012 12:23

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  35. Content type: Research article

    Valvulogenesis and septation in the developing heart depend on the formation and remodeling of endocardial cushions in the atrioventricular canal (AVC) and outflow tract (OFT). These cushions are invaded by a ...

    Authors: Kathryn E LeMasters, Yotam Blech-Hermoni, Samantha J Stillwagon, Natalie A Vajda and Andrea N Ladd

    Citation: BMC Developmental Biology 2012 12:22

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  36. Content type: Research article

    Calpains are calcium regulated intracellular cysteine proteases implicated in a variety of physiological functions and pathological conditions. The Drosophila melanogaster genome contains only two genes, CalpA an...

    Authors: Endre Kókai, Ferencz Sándor Páldy, Kálmán Somogyi, Anil Chougule, Margit Pál, Éva Kerekes, Péter Deák, Péter Friedrich, Viktor Dombrádi and Géza Ádám

    Citation: BMC Developmental Biology 2012 12:20

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  37. Content type: Research article

    The peptidylarginine deiminases (PADIs) convert positively charged arginine residues to neutrally charged citrulline on protein substrates in a process that is known as citrullination or deimination. Previous ...

    Authors: Rui Kan, Mei Jin, Venkataraman Subramanian, Corey P Causey, Paul R Thompson and Scott A Coonrod

    Citation: BMC Developmental Biology 2012 12:19

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  38. Content type: Methodology article

    To facilitate the in vivo study of esophageal (stem) cell biology in homeostasis and cancer, novel mouse models are necessary to elicit expression of candidate genes in a tissue-specific and inducible fashion. To...

    Authors: Sabrina Roth, Patrick Franken, Kim Monkhorst, John Kong a San and Riccardo Fodde

    Citation: BMC Developmental Biology 2012 12:18

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  39. Content type: Research article

    Wnts are a family of secreted signaling molecules involved in a number of developmental processes including the establishment of cell fate, polarity and proliferation. Recent studies also implicate wnts in epi...

    Authors: Macalister Usongo and Riaz Farookhi

    Citation: BMC Developmental Biology 2012 12:17

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  40. Content type: Research article

    Histone deacetylase-4 (Hdac4) is a class II histone deacetylase that inhibits the activity of transcription factors. In humans, HDAC4 deficiency is associated with non-syndromic oral clefts and brachydactyly m...

    Authors: April DeLaurier, Yukio Nakamura, Ingo Braasch, Vishesh Khanna, Hiroyuki Kato, Shigeyuki Wakitani, John H Postlethwait and Charles B Kimmel

    Citation: BMC Developmental Biology 2012 12:16

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  41. Content type: Research article

    A hallmark of Drosophila segmentation is the stepwise subdivision of the body into smaller and smaller units, and finally into the segments. This is achieved by the function of the well-understood segmentation ge...

    Authors: Ralf Janssen, Wim G M Damen and Graham E Budd

    Citation: BMC Developmental Biology 2012 12:15

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  42. Content type: Research article

    A metamorphic life-history is present in the majority of animal phyla. This developmental mode is particularly prominent among marine invertebrates with a bentho-planktonic life cycle, where a pelagic larval f...

    Authors: Josh Sutherby, Jamie-Lee Giardini, Julia Nguyen, Gary Wessel, Mariana Leguia and Andreas Heyland

    Citation: BMC Developmental Biology 2012 12:14

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    The Erratum to this article has been published in BMC Developmental Biology 2013 13:30

  43. Content type: Research article

    The mammary gland is key to all mammal species; in particular in multiparous species like pigs the number and the shape of functional mammary gland complexes are major determinants of fitness. Accordingly, we ...

    Authors: Kunsuda Chomwisarutkun, Eduard Murani, Siriluck Ponsuksili and Klaus Wimmers

    Citation: BMC Developmental Biology 2012 12:13

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  44. Content type: Research article

    Folic acid supplementation reduces the risk of neural tube defects and congenital heart defects. The biological mechanisms through which folate prevents birth defects are not well understood. We explore the us...

    Authors: Marina S Lee, Jenna R Bonner, David J Bernard, Erica L Sanchez, Eric T Sause, R Reid Prentice, Shawn M Burgess and Lawrence C Brody

    Citation: BMC Developmental Biology 2012 12:12

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  45. Content type: Research article

    Among the four major bilaterian clades, Deuterostomia, Acoelomorpha, Ecdysozoa, and Lophotrochozoa, the latter shows an astonishing diversity of bodyplans. While the largest lophotrochozoan assemblage, the Spi...

    Authors: Julia Merkel, Tim Wollesen, Bernhard Lieb and Andreas Wanninger

    Citation: BMC Developmental Biology 2012 12:11

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  46. Content type: Research article

    During early stages of brain development, secreted molecules, components of intracellular signaling pathways and transcriptional regulators act in positive and negative feed-back or feed-forward loops at the m...

    Authors: Zsuzsa Agoston, Naixin Li, Anja Haslinger, Andrea Wizenmann and Dorothea Schulte

    Citation: BMC Developmental Biology 2012 12:10

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  47. Content type: Research article

    Mammals are not able to restore lost appendages, while many amphibians are. One important question about epimorphic regeneration is related to the origin of the new tissues and whether they come from mature ce...

    Authors: Alexandre Miguel Cavaco Rodrigues, Bea Christen, Mercé Martí and Juan Carlos Izpisúa Belmonte

    Citation: BMC Developmental Biology 2012 12:9

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  48. Content type: Research article

    The formation of a tubular organ, such as the heart, requires the communication of positional and polarity signals between migratory cells. Key to this process is the establishment of a new luminal domain on t...

    Authors: Jessica Vanderploeg, L Lourdes Vazquez Paz, Allison MacMullin and J Roger Jacobs

    Citation: BMC Developmental Biology 2012 12:8

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