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  1. During Drosophila development, titers of the steroid ecdysone trigger and maintain temporal and tissue specific biological transitions. Decades of evidence reveal that the ecdysone response is both unique to spec...

    Authors: Melissa B Davis, Inigo SanGil, Grace Berry, Rashidat Olayokun and Lori H Neves

    Citation: BMC Developmental Biology 2011 11:66

    Content type: Research article

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  2. The T-box transcription factor TBX3 is necessary for early embryonic development and for the normal development of the mammary gland. Homozygous mutations, in mice, are embryonic lethal while heterozygous muta...

    Authors: Jing Liu, Taraneh Esmailpour, Xiying Shang, Gultekin Gulsen, Andy Liu and Taosheng Huang

    Citation: BMC Developmental Biology 2011 11:65

    Content type: Research article

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  3. Identifying DNA sequences (enhancers) that direct the precise spatial and temporal expression of developmental control genes remains a significant challenge in the annotation of vertebrate genomes. Locating th...

    Authors: Sumantra Chatterjee, Guillaume Bourque and Thomas Lufkin

    Citation: BMC Developmental Biology 2011 11:63

    Content type: Research article

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  4. We recently identified Rbm24 as a novel gene expressed during mouse cardiac development. Due to its tightly restricted and persistent expression from formation of the cardiac crescent onwards and later in forming...

    Authors: Samantha Maragh, Ronald A Miller, Seneca L Bessling, David M McGaughey, Marja W Wessels, Bianca de Graaf, Eric A Stone, Aida M Bertoli-Avella, John D Gearhart, Shannon Fisher and Andrew S McCallion

    Citation: BMC Developmental Biology 2011 11:62

    Content type: Research article

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  5. Determining the type and source of cells involved in regenerative processes has been one of the most important goals of researchers in the field of regeneration biology. We have previously used several cellula...

    Authors: José E García-Arrarás, Griselle Valentín-Tirado, Jaime E Flores, Rey J Rosa, Angélica Rivera-Cruz, José E San Miguel-Ruiz and Karen Tossas

    Citation: BMC Developmental Biology 2011 11:61

    Content type: Research article

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  6. Valuable insights into the complex process of retinal vascular development can be gained using models with abnormal retinal vasculature. Two such models are the recently described mouse lines with mutations in La...

    Authors: Malia M Edwards, D Scott McLeod, Rhonda Grebe, Céline Heng, Olivier Lefebvre and Gerard A Lutty

    Citation: BMC Developmental Biology 2011 11:60

    Content type: Research article

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  7. Sox6 is a multi-faceted transcription factor involved in the terminal differentiation of many different cell types in vertebrates. It has been suggested that in mice as well as in zebrafish Sox6 plays a role i...

    Authors: Chung-Il An, Yao Dong and Nobuko Hagiwara

    Citation: BMC Developmental Biology 2011 11:59

    Content type: Research article

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  8. TG-interacting factors (TGIFs) belong to a family of TALE-homeodomain proteins including TGIF1, TGIF2 and TGIFLX/Y in human. Both TGIF1 and TGIF2 act as transcription factors repressing TGF-β signalling. Human TG...

    Authors: Yanqiu Hu, Hongshi Yu, Geoff Shaw, Marilyn B Renfree and Andrew J Pask

    Citation: BMC Developmental Biology 2011 11:58

    Content type: Research article

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  9. Epithelial neoplasias are associated with alterations in cell polarity and excessive cell proliferation, yet how these neoplastic properties are related to one another is still poorly understood. The study of Dro...

    Authors: Karen Doggett, Felix A Grusche, Helena E Richardson and Anthony M Brumby

    Citation: BMC Developmental Biology 2011 11:57

    Content type: Research article

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  10. During liver development, intrahepatic bile ducts are thought to arise by a unique asymmetric mode of cholangiocyte tubulogenesis characterized by a series of remodeling stages. Moreover, in liver diseases, ce...

    Authors: Peter S Vestentoft, Peter Jelnes, Branden M Hopkinson, Ben Vainer, Kjeld Møllgård, Bjørn Quistorff and Hanne C Bisgaard

    Citation: BMC Developmental Biology 2011 11:56

    Content type: Research article

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  11. Rapid advances in genomics have provided nearly complete genome sequences for many different species. However, no matter how the sequencing technology has improved, natural genetic polymorphism complicates the...

    Authors: Irene E Samonte-Padilla, Christophe Eizaguirre, Jörn P Scharsack, Tobias L Lenz and Manfred Milinski

    Citation: BMC Developmental Biology 2011 11:55

    Content type: Methodology article

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  12. Surgical removal of the lens from larval Xenopus laevis results in a rapid transdifferention of central corneal cells to form a new lens. The trigger for this process is understood to be an induction event arisin...

    Authors: Robert C Day and Caroline W Beck

    Citation: BMC Developmental Biology 2011 11:54

    Content type: Research article

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  13. Nkx2.2 and Arx represent key transcription factors implicated in the specification of islet cell subtypes during pancreas development. Mice deficient for Arx do not develop any alpha-cells whereas beta- and delta...

    Authors: Simon Kordowich, Patrick Collombat, Ahmed Mansouri and Palle Serup

    Citation: BMC Developmental Biology 2011 11:52

    Content type: Research article

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  14. Retinoic acid (RA) is important for vertebrate eye morphogenesis and is a regulator of photoreceptor development in the retina. In the zebrafish, RA treatment of postmitotic photoreceptor precursors has been s...

    Authors: Craig B Stevens, David A Cameron and Deborah L Stenkamp

    Citation: BMC Developmental Biology 2011 11:51

    Content type: Research article

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  15. We recently identified a novel oncogene, Cancer-upregulated gene 2 (CUG2), which is essential for kinetochore formation and promotes tumorigenesis in mammalian cells. However, the in vivo function of CUG2 has ...

    Authors: Hyun-Taek Kim, Ju-Hoon So, Seung-Hyun Jung, Dae-Gwon Ahn, Wansoo Koh, Nam-Soon Kim, Soo-Hyun Kim, Soojin Lee and Cheol-Hee Kim

    Citation: BMC Developmental Biology 2011 11:49

    Content type: Research article

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  16. Despite the detailed knowledge obtained over the last decade on the molecular regulation of gastrulation in amniotes, the process of amnion development has been poorly described and illustrated in mice, and co...

    Authors: Paulo NG Pereira, Mariya P Dobreva, Liz Graham, Danny Huylebroeck, Kirstie A Lawson and AN Zwijsen

    Citation: BMC Developmental Biology 2011 11:48

    Content type: Research article

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  17. The development of vertebrate limbs has been a traditional system to study fundamental processes at work during ontogenesis, such as the establishment of spatial cellular coordinates, the effect of diffusible ...

    Authors: Istvan Gyurján, Bernhard Sonderegger, Felix Naef and Denis Duboule

    Citation: BMC Developmental Biology 2011 11:47

    Content type: Research article

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  18. Understanding the mechanisms governing cell fate specification remains one of the main challenges in the study of retinal development. In this context, molecular markers that identify specific cell types becom...

    Authors: Christian Gutierrez, Minda McNally and M Valeria Canto-Soler

    Citation: BMC Developmental Biology 2011 11:46

    Content type: Research article

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  19. In a recent genomic study, Leung et al. used a factorial microarray analysis to identify Smarca4 (Brg1)-regulated genes in micro-dissected zebrafish retinas. Two hundred and fifty nine genes were grouped in th...

    Authors: Monica R Hensley, Farida Emran, Sylvia Bonilla, Liyun Zhang, Wenxuan Zhong, Paul Grosu, John E Dowling and Yuk Fai Leung

    Citation: BMC Developmental Biology 2011 11:45

    Content type: Research article

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  20. In vitro studies using the myogenic cell line C2C12 demonstrate that bone morphogenetic protein-2 (BMP-2) converts the developmental pathway of C2C12 from a myogenic cell lineage to an osteoblastic cell lineag...

    Authors: Kayoko Aoyama, Akira Yamane, Takeo Suga, Erika Suzuki, Tadayoshi Fukui and Yoshiki Nakamura

    Citation: BMC Developmental Biology 2011 11:44

    Content type: Research article

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  21. Whole-mount in situ hybridization (WISH) is extensively used to characterize gene expression patterns in developing and adult brain and other tissues. To obtain an idea whether a novel gene might be involved in s...

    Authors: Gilbert Lauter, Iris Söll and Giselbert Hauptmann

    Citation: BMC Developmental Biology 2011 11:43

    Content type: Methodology article

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  22. Loss of heterozygosity at 18q, which includes the Deleted in Colorectal Cancer (DCC) gene, has been linked to many human cancers. However, it is unclear if loss of DCC is the specific underlying cause of these ca...

    Authors: Adrienne VanZomeren-Dohm, Joseph Sarro, Ellen Flannery and Molly Duman-Scheel

    Citation: BMC Developmental Biology 2011 11:41

    Content type: Research article

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  23. The ERBB3 gene is essential for the proper development of the neural crest (NC) and its derivative populations such as Schwann cells. As with all cell fate decisions, transcriptional regulatory control plays a si...

    Authors: Megana K Prasad, Xylena Reed, David U Gorkin, Julia C Cronin, Anthony R McAdow, Kristopher Chain, Chani J Hodonsky, Erin A Jones, John Svaren, Anthony Antonellis, Stephen L Johnson, Stacie K Loftus, William J Pavan and Andrew S McCallion

    Citation: BMC Developmental Biology 2011 11:40

    Content type: Research article

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  24. Heparan sulfate (HS) is present on the surface of virtually all mammalian cells and is a major component of the extracellular matrix (ECM), where it plays a pivotal role in cell-cell and cell-matrix cross-talk...

    Authors: Sophie M Thompson, Marilyn G Connell, Toin H van Kuppevelt, Ruoyan Xu, Jeremy E Turnbull, Paul D Losty, David G Fernig and Edwin C Jesudason

    Citation: BMC Developmental Biology 2011 11:38

    Content type: Research article

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  25. Sphingosine-1-phosophate (S1P) is a biologically active sphingolipid metabolite that influences cellular events including differentiation, proliferation, and migration. S1P acts through five distinct cell surf...

    Authors: Ryan R Poulsen, Carolyn M McClaskey, Scott A Rivkees and Christopher C Wendler

    Citation: BMC Developmental Biology 2011 11:37

    Content type: Research article

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  26. Paraxial protocadherin (PAPC) plays a crucial role in morphogenetic movements during gastrulation and somitogenesis in mouse, zebrafish and Xenopus. PAPC influences cell-cell adhesion mediated by C-Cadherin. A...

    Authors: Barbara Jung, Almut Köhler, Alexandra Schambony and Doris Wedlich

    Citation: BMC Developmental Biology 2011 11:36

    Content type: Research article

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  27. Teneurin-1 is a member of a family of type II transmembrane proteins conserved from C.elegans to vertebrates. Teneurin expression in vertebrates is best studied in mouse and chicken, where the four members teneur...

    Authors: Jan Beckmann, Antonio Vitobello, Jacqueline Ferralli, Daniela Kenzelmann Brož, Filippo M Rijli and Ruth Chiquet-Ehrismann

    Citation: BMC Developmental Biology 2011 11:35

    Content type: Research article

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  28. MicroRNAs (miRNAs) are small RNA molecules that post-transcriptionally regulate gene expression and have been shown to play an important role during development. miR-1, miR-133a, miR-133b and miR-206 are expre...

    Authors: Andrie Koutsoulidou, Nikolaos P Mastroyiannopoulos, Denis Furling, James B Uney and Leonidas A Phylactou

    Citation: BMC Developmental Biology 2011 11:34

    Content type: Research article

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  29. Two stages of genome activation have been identified in the mouse embryo. Specifically, minor transcriptional activation is evident at the one-cell stage and a second major episode of activation occurs at the ...

    Authors: Reza K Oqani, Hong R Kim, Yun F Diao, Chang S Park and Dong I Jin

    Citation: BMC Developmental Biology 2011 11:33

    Content type: Research article

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  30. The Drosophila wing represents a particularly appropriate model to investigate the developmental control of phenotypic variation. Previous studies which aimed to identify candidate genes for wing morphology demon...

    Authors: Valeria P Carreira, Ignacio M Soto, Julián Mensch and Juan J Fanara

    Citation: BMC Developmental Biology 2011 11:32

    Content type: Research article

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  31. The metamorphosis of the spionid polychaete Pseudopolydora vexillosa includes spontaneous settlement onto soft-bottom habitats and morphogenesis that can be completed in a very short time. A previous study on the...

    Authors: Kondethimmanahalli H Chandramouli, Flora SY Mok, Hao Wang and Pei-Yuan Qian

    Citation: BMC Developmental Biology 2011 11:31

    Content type: Research article

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  32. The transition from fertilized egg to embryo is accompanied by a multitude of changes in gene expression, and the transcriptional events that underlie these processes have not yet been fully characterized. In ...

    Authors: Liselotte Vesterlund, Hong Jiao, Per Unneberg, Outi Hovatta and Juha Kere

    Citation: BMC Developmental Biology 2011 11:30

    Content type: Research article

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  33. Consistent asymmetry of the left-right (LR) axis is a crucial aspect of vertebrate embryogenesis. Asymmetric gene expression of the TGFβ superfamily member Nodal related 1 (Nr1) in the left lateral mesoderm plate...

    Authors: Katia Carneiro, Claudia Donnet, Tomas Rejtar, Barry L Karger, Gustavo A Barisone, Elva Díaz, Sandhya Kortagere, Joan M Lemire and Michael Levin

    Citation: BMC Developmental Biology 2011 11:29

    Content type: Research article

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  34. The zinc finger transcription factor Egr-1 (Early growth response 1) is central to several growth factors and represents an important activator of target genes not only involved in physiological processes like...

    Authors: Philipp Dussmann, Judith I Pagel, Sabina Vogel, Terese Magnusson, Rene Zimmermann, Ernst Wagner, Wolfgang Schaper, Manfred Ogris and Elisabeth Deindl

    Citation: BMC Developmental Biology 2011 11:28

    Content type: Research article

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  35. Neurogenesis control and the prevention of premature differentiation in the vertebrate embryo are crucial processes, allowing the formation of late-born cell types and ensuring the correct shape and cytoarchit...

    Authors: Katharine J Webb, Marion Coolen, Christian J Gloeckner, Christian Stigloher, Brigitte Bahn, Stefanie Topp, Marius Ueffing and Laure Bally-Cuif

    Citation: BMC Developmental Biology 2011 11:27

    Content type: Research article

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  36. The embryonic organizer (i.e., Spemann organizer) has a pivotal role in the establishment of the dorsoventral (DV) axis through the coordination of BMP signaling. However, as impaired organizer function also r...

    Authors: Máté Varga, Shingo Maegawa and Eric S Weinberg

    Citation: BMC Developmental Biology 2011 11:26

    Content type: Research article

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  37. Oocyte-derived maternal RNAs drive early embryogenesis when the newly formed embryo is transcriptionally inactive. Recent studies in zebrafish have identified the role of microRNAs during the maternal-to-embry...

    Authors: Swamy K Tripurani, Kyung-Bon Lee, Gabbine Wee, George W Smith and Jianbo Yao

    Citation: BMC Developmental Biology 2011 11:25

    Content type: Research article

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  38. Peroxisomes are organelles whose roles in fatty acid metabolism and reactive oxygen species elimination have contributed much attention in understanding their origin and biogenesis. Many studies have shown that d...

    Authors: Mark A Fox, Logan A Walsh, Michelle Nieuwesteeg and Sashko Damjanovski

    Citation: BMC Developmental Biology 2011 11:24

    Content type: Research article

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  39. Bryozoans represent a large lophotrochozoan phylum with controversially discussed phylogenetic position and in group relationships. Developmental processes during the budding of bryozoans are in need for revis...

    Authors: Thomas Schwaha and Timothy S Wood

    Citation: BMC Developmental Biology 2011 11:23

    Content type: Research article

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  40. Lipid rafts enriched in glycosphingolipids (GSLs), cholesterol and signaling molecules play an essential role not only for signal transduction started by ligand binding, but for intracellular events such as or...

    Authors: Ban Sato, Yohko U Katagiri, Kenji Miyado, Nozomu Okino, Makoto Ito, Hidenori Akutsu, Hajime Okita, Akihiro Umezawa, Junichiro Fujimoto, Kiyotaka Toshimori and Nobutaka Kiyokawa

    Citation: BMC Developmental Biology 2011 11:22

    Content type: Research article

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  41. FGF signalling regulates numerous aspects of early embryo development. During gastrulation in amniotes, epiblast cells undergo an epithelial to mesenchymal transition (EMT) in the primitive streak to form the ...

    Authors: Katharine M Hardy, Tatiana A Yatskievych, JH Konieczka, Alexander S Bobbs and Parker B Antin

    Citation: BMC Developmental Biology 2011 11:20

    Content type: Research article

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  42. The gene transformer-2, which is involved in sex determination, has been studied in Drosophila, Musca, Ceratitis, Anastrepha and Lucilia. All these members of Diptera belong to the suborder Brachycera. In this wo...

    Authors: Iker Martín, María F Ruiz and Lucas Sánchez

    Citation: BMC Developmental Biology 2011 11:19

    Content type: Research article

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  43. Endothelial-specific knockout of the transcription factor serum response factor (SRF) results in embryonic lethality by mid-gestation. The associated phenotype exhibits vascular failure in embryos as well as v...

    Authors: Mary L Holtz and Ravi P Misra

    Citation: BMC Developmental Biology 2011 11:18

    Content type: Research article

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  44. Mitogen-activated protein kinase (MAPK) cascades (p38, JNK, ERK pathways) are involved in cell fate acquisition during development. These kinase modules are associated with scaffold proteins that control their...

    Authors: Emmanuèle Mouchel-Vielh, Julien Rougeot, Martine Decoville and Frédérique Peronnet

    Citation: BMC Developmental Biology 2011 11:17

    Content type: Research article

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