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  1. Central American crater lake cichlid fish of the Midas species complex (Amphilophus spp.) are a model system for sympatric speciation and fast ecological diversification and specialization. Midas cichlids have be...

    Authors: Claudius F Kratochwil, Maggie M Sefton and Axel Meyer

    Citation: BMC Developmental Biology 2015 15:12

    Content type: Research article

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  2. Tissue fixation is crucial for preserving the morphology of biological structures and cytological details to prevent postmortem degradation and autolysis. Improper fixation conditions could lead to artifacts a...

    Authors: Jing Nie, Simpla Mahato and Andrew C Zelhof

    Citation: BMC Developmental Biology 2015 15:10

    Content type: Methodology article

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  3. Primary cilia are essential for Hedgehog (Hh) signal transduction in vertebrates. Although the core components of the Hh pathway are highly conserved, the dependency on cilia in Hh signaling is considered to b...

    Authors: Takayoshi Yamamoto, Tatsuya Tsukahara, Tadashi Ishiguro, Haruo Hagiwara, Masanori Taira and Hiroyuki Takeda

    Citation: BMC Developmental Biology 2015 15:9

    Content type: Research article

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  4. Stem cells can respond to environmental and physiological inputs to adaptively remodel tissues. Little is known about whether stem cell niches are similarly responsive. The Drosophila ovary germline stem cell (GS...

    Authors: Alessandro Bonfini, Marian B Wilkin and Martin Baron

    Citation: BMC Developmental Biology 2015 15:8

    Content type: Research article

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  5. Alveoli, the milk-producing units of the mammary gland, are generated during pregnancy by collaboration of different epithelial cell types. We present the first analysis of transcriptional changes within the h...

    Authors: Duvini De Silva, Kamini Kunasegaran, Sujoy Ghosh and Alexandra M Pietersen

    Citation: BMC Developmental Biology 2015 15:7

    Content type: Research article

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  6. We have revealed that the type II diacylglycerol kinases (DGKs) δ, η and κ were expressed in the testis and ovary. However, these enzymes’ functions in the reproductive organs remain unknown.

    Authors: Takao Shionoya, Takako Usuki, Suguru Komenoi, Takeshi Isozaki, Hiromichi Sakai and Fumio Sakane

    Citation: BMC Developmental Biology 2015 15:6

    Content type: Research article

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  7. The editors of BMC Developmental Biology would like to thank all our reviewers who have contributed to the journal in Volume 14 (2014).

    Authors: Philippa K Harris

    Citation: BMC Developmental Biology 2015 15:5

    Content type: Reviewer acknowledgement

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  8. In society, there is a clear need to improve the success rate of techniques to restore fertility. Therefore a deeper knowledge of the dynamics of the complex molecular environment that regulates human gametoge...

    Authors: A Marijne Heeren, Liesbeth van Iperen, Daniëlle B Klootwijk, Ana de Melo Bernardo, Matthias S Roost, Maria M Gomes Fernandes, Leonie A Louwe, Carina G Hilders, Frans M Helmerhorst, Lucette A J van der Westerlaken and Susana M Chuva de Sousa Lopes

    Citation: BMC Developmental Biology 2015 15:4

    Content type: Research article

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  9. Dietary interventions during pregnancy alter offspring fitness. We have shown mouse maternal low protein diet fed exclusively for the preimplantation period (Emb-LPD) before return to normal protein diet (NPD)...

    Authors: Congshan Sun, Oleg Denisenko, Bhavwanti Sheth, Andy Cox, Emma S Lucas, Neil R Smyth and Tom P Fleming

    Citation: BMC Developmental Biology 2015 15:3

    Content type: Research article

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  10. Planarians are an attractive model organism for studying stem cell-based regeneration due to their ability to replace all of their tissues from a population of adult stem cells. The molecular toolkit for plana...

    Authors: Kelly G Ross, Kerilyn C Omuro, Matthew R Taylor, Roma K Munday, Amy Hubert, Ryan S King and Ricardo M Zayas

    Citation: BMC Developmental Biology 2015 15:2

    Content type: Methodology article

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  11. Bioelectric phenomena have been found to exert influence on various developmental and regenerative processes. Little is known about their possible functions and the cellular mechanisms by which they might act ...

    Authors: Julia Krüger and Johannes Bohrmann

    Citation: BMC Developmental Biology 2015 15:1

    Content type: Research article

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  12. Zebrafish are able to regenerate many of its tissues and organs after damage. In amphibians this process is regulated by nerve fibres present at the site of injury, which have been proposed to release factors ...

    Authors: Mariana G Simões, Anabela Bensimon-Brito, Mariana Fonseca, Ana Farinho, Fábio Valério, Sara Sousa, Nuno Afonso, Anoop Kumar and Antonio Jacinto

    Citation: BMC Developmental Biology 2014 14:49

    Content type: Research article

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  13. Mapping of tissue structure at the cellular, circuit, and organ-wide scale is important for understanding physiological and biological functions. A bio-electrochemical technique known as CLARITY used for three...

    Authors: Hyunsu Lee, Jae-Hyung Park, Incheol Seo, Sun-Hyun Park and Shin Kim

    Citation: BMC Developmental Biology 2014 14:48

    Content type: Methodology article

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  14. Efforts to elucidate the cellular and molecular mechanisms of regeneration have required the application of methods to detect specific cell types and tissues in a growing cohort of experimental animal models. ...

    Authors: David J Forsthoefel, Forrest A Waters and Phillip A Newmark

    Citation: BMC Developmental Biology 2014 14:45

    Content type: Methodology article

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  15. Identification and characterization of molecular controls that regulate mammary stem and progenitor cell homeostasis are critical to our understanding of normal mammary gland development and its pathology.

    Authors: Gautam K Malhotra, Xiangshan Zhao, Emily Edwards, Janel L Kopp, Mayumi Naramura, Maike Sander, Hamid Band and Vimla Band

    Citation: BMC Developmental Biology 2014 14:47

    Content type: Research article

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  16. In standard cell division, the cells undergo karyokinesis and then cytokinesis. Some cells, however, such as cardiomyocytes and hepatocytes, can produce binucleate cells by going through mitosis without cytoki...

    Authors: Kiichiro Taniguchi, Akihiko Kokuryo, Takao Imano, Ryunosuke Minami, Hideki Nakagoshi and Takashi Adachi-Yamada

    Citation: BMC Developmental Biology 2014 14:46

    Content type: Research article

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  17. The development of the craniofacial skeleton from embryonic mesenchyme is a complex process that is not yet completely understood, particularly for intramembranous bones. This study investigates the developmen...

    Authors: Carolyn T Chang and Tamara Anne Franz-Odendaal

    Citation: BMC Developmental Biology 2014 14:44

    Content type: Research article

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  18. The mechanistic target of rapamycin complex1 (mTORC1) signaling pathway has been implicated in functions of multicellular processes, including cell growth and metabolism. Although recent reports showed that ma...

    Authors: Kentaro Hirose, Taishi Shiomi, Shunya Hozumi and Yutaka Kikuchi

    Citation: BMC Developmental Biology 2014 14:42

    Content type: Research article

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  19. The homeodomain transcription factor orthopedia (Otp) is an evolutionarily conserved regulator of neuronal fates. In vertebrates, Otp is necessary for the proper development of different regions of the brain a...

    Authors: Jose Arturo Gutierrez-Triana, Ulrich Herget, Patrick Lichtner, Luis A Castillo-Ramírez and Soojin Ryu

    Citation: BMC Developmental Biology 2014 14:41

    Content type: Research article

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  20. The sub-cortical maternal complex (SCMC), located in the subcortex of mouse oocytes and preimplantation embryos, is composed of at least four proteins encoded by maternal effect genes: OOEP, NLRP5/MATER, TLE6 ...

    Authors: Daniela Bebbere, Federica Ariu, Luisa Bogliolo, Laura Masala, Ombretta Murrone, Mauro Fattorini, Laura Falchi and Sergio Ledda

    Citation: BMC Developmental Biology 2014 14:40

    Content type: Research article

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  21. The switch from cartilage template to bone during endochondral ossification of the growth plate requires a dynamic and close interaction between cartilage and the developing vasculature. Vascular invasion of t...

    Authors: Sonja M Walzer, Erdal Cetin, Ruth Grübl-Barabas, Irene Sulzbacher, Beate Rueger, Werner Girsch, Stefan Toegel, Reinhard Windhager and Michael B Fischer

    Citation: BMC Developmental Biology 2014 14:36

    Content type: Research article

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  22. Members of the Semaphorin 3 family (Sema3s) influence the development of the central nervous system, and some are implicated in regulating aspects of visual system development. However, we lack information abo...

    Authors: Anil Sharma, Chrisna J LeVaillant, Giles W Plant and Alan R Harvey

    Citation: BMC Developmental Biology 2014 14:34

    Content type: Research article

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    The Erratum to this article has been published in BMC Developmental Biology 2014 14:39

  23. The 14-3-3 (YWHA) proteins are highly conserved in higher eukaryotes, participate in various cellular signaling pathways including cell cycle regulation, development and growth. Our previous studies demonstrat...

    Authors: Cheng Cui, Xiuli Ren, Dajun Liu, Xin Deng, Xin Qin, Xiangyu Zhao, Enhua Wang and Bingzhi Yu

    Citation: BMC Developmental Biology 2014 14:33

    Content type: Research article

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  24. To gain insight into what differences might restrict the capacity for limb regeneration in Xenopus froglets, we used High Performance Liquid Chromatography (HPLC)/double mass spectrometry to characterize protein ...

    Authors: Nandini Rao, Fengyu Song, Deepali Jhamb, Mu Wang, Derek J Milner, Nathaniel M Price, Teri L Belecky-Adams, Mathew J Palakal, Jo Ann Cameron, Bingbing Li, Xiaoping Chen and David L Stocum

    Citation: BMC Developmental Biology 2014 14:32

    Content type: Research article

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  25. Morphometric quantification of subtle craniofacial variation in studies of experimentally modified embryonic mice has proved valuable in determining the effects of developmental perturbations on craniofacial m...

    Authors: Christopher J Percival, Rebecca Green, Ralph Marcucio and Benedikt Hallgrímsson

    Citation: BMC Developmental Biology 2014 14:31

    Content type: Methodology article

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  26. Histone deacetylases (HDACs) play important roles in glial cell development and in disease states within multiple regions of the central nervous system. However, little is known about HDAC expression or functi...

    Authors: Sarika Tiwari, Subramanian Dharmarajan, Mahesh Shivanna, Deborah C Otteson and Teri L Belecky-Adams

    Citation: BMC Developmental Biology 2014 14:30

    Content type: Research article

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  27. The retinal pigmented epithelium (RPE) is a rounded shaped structure in almost all lizards. In the New World dwarf geckos, this structure shows an unusual morphology. In addition to this ocular character, we d...

    Authors: Ricardo A Guerra-Fuentes, Juan D Daza and Aaron M Bauer

    Citation: BMC Developmental Biology 2014 14:29

    Content type: Research article

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  28. Dimethyl sulfoxide (DMSO) is used extensively as a permeable cryoprotectant and is a common solvent utilized for several water-insoluble substances. DMSO has various biological and pharmacological activities; ...

    Authors: Dongjie Zhou, Xinghui Shen, Yanli Gu, Na Zhang, Tong Li, Xi Wu and Lei Lei

    Citation: BMC Developmental Biology 2014 14:28

    Content type: Research article

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  29. The Drosophila heart (dorsal vessel) is a relatively simple tubular organ that serves as a model for several aspects of cardiogenesis. Cardiac morphogenesis, proper heart function and stability require structural...

    Authors: Dominik Hollfelder, Manfred Frasch and Ingolf Reim

    Citation: BMC Developmental Biology 2014 14:26

    Content type: Research article

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  30. The developing vertebrate hindbrain is transiently segmented into rhombomeres by a process requiring Hox activity. Hox genes control specification of rhombomere fates, as well as the stereotypic differentiation o...

    Authors: Steven E Weicksel, Ankit Gupta, Denise A Zannino, Scot A Wolfe and Charles G Sagerström

    Citation: BMC Developmental Biology 2014 14:25

    Content type: Research article

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  31. Chloride Intracellular Channel 4 (CLIC4) is one of seven members in the closely related CLIC protein family. CLIC4 is involved in multiple cellular processes including apoptosis, cellular differentiation, infl...

    Authors: VC Padmakumar, Katelyn E Masiuk, Dror Luger, Christina Lee, Vincenzo Coppola, Lino Tessarollo, Shelley B Hoover, Irina Karavanova, Andres Buonanno, R Mark Simpson and Stuart H Yuspa

    Citation: BMC Developmental Biology 2014 14:24

    Content type: Research article

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  32. The DNA damage-mediated cell cycle checkpoint is an essential mechanism in the DNA damage response (DDR). During embryonic development, the characteristics of cell cycle and DNA damage checkpoint evolve from a...

    Authors: Xiao Qi Wang, Kwok Kin Chan, Xiaoyan Ming, Vincent CH Lui, Randy YC Poon, Chung Mau Lo, Chris Norbury and Ronnie TP Poon

    Citation: BMC Developmental Biology 2014 14:23

    Content type: Research article

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  33. The purple sea urchin, Strongylocentrotus purpuratus, has long been the focus of developmental and ecological studies, and its recently-sequenced genome has spawned a diversity of functional genomics approaches.

    Authors: Andreas Heyland and Jason Hodin

    Citation: BMC Developmental Biology 2014 14:22

    Content type: Methodology article

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  34. Bone marrow derived mesenchymal stem cells (bmMSCs) are multipotent cells that can differentiate into diverse cell types, including cardiomyocytes. BmMSC-based transplantation is capable of repairing acute and...

    Authors: Junfang Wu, Jie Niu, Xiaopeng Li, Xianwei Wang, Zhikun Guo and Fenxi Zhang

    Citation: BMC Developmental Biology 2014 14:21

    Content type: Research article

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  35. Circadian clocks have been postulated to regulate development time in several species of insects including fruit flies Drosophila melanogaster. Previously we have reported that selection for faster pre-adult deve...

    Authors: Pankaj Yadav, Madhumohan Thandapani and Vijay Kumar Sharma

    Citation: BMC Developmental Biology 2014 14:19

    Content type: Research article

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  36. The outermost layer of the vertebrate heart, the epicardium, forms from a cluster of progenitor cells termed the proepicardium (PE). PE cells migrate onto the myocardium to give rise to the epicardium. Impaire...

    Authors: Jessica S Plavicki, Peter Hofsteen, Monica S Yue, Kevin A Lanham, Richard E Peterson and Warren Heideman

    Citation: BMC Developmental Biology 2014 14:18

    Content type: Research article

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  37. Hox genes encode master regulators of regional fate specification during early metazoan development. Much is known about the initiation and regulation of Hox gene expression in Drosophila and vertebrates, but ...

    Authors: Wan-Ju Liu, John S Reece-Hoyes, Albertha JM Walhout and David M Eisenmann

    Citation: BMC Developmental Biology 2014 14:17

    Content type: Research article

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  38. The miniature pig provides an excellent experimental model for tooth morphogenesis because its diphyodont and heterodont dentition resembles that of humans. However, little information is available on the proc...

    Authors: Tieli Song, Tingting Wu, Fulan Wei, Ang Li, Fu Wang, Yilin Xie, Dayong Liu, Zhipeng Fan, Xuejiu Wang, Shan Cheng, Chunmei Zhang, Junqi He and Songlin Wang

    Citation: BMC Developmental Biology 2014 14:16

    Content type: Research article

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  39. Mosquito eggshells show remarkable diversity in physical properties and structure consistent with adaptations to the wide variety of environments exploited by these insects. We applied proteomic, transcriptomi...

    Authors: Osvaldo Marinotti, Tuan Ngo, Bianca B Kojin, Shao-Pei Chou, Brian Nguyen, Jennifer Juhn, Rebeca Carballar-Lejarazú, Pedro N Marinotti, Xiaofang Jiang, Marika F Walter, Zhijian Tu, Paul D Gershon and Anthony A James

    Citation: BMC Developmental Biology 2014 14:15

    Content type: Research article

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  40. Serotonin (5-HT) is well known as widely distributed modulator of developmental processes in both vertebrates and invertebrates. It is also the earliest neurotransmitter to appear during neuronal development. ...

    Authors: Konstantin Glebov, Elena E Voronezhskaya, Marina Yu Khabarova, Evgeny Ivashkin, Leonid P Nezlin and Evgeni G Ponimaskin

    Citation: BMC Developmental Biology 2014 14:14

    Content type: Research article

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  41. Differences in cranial morphology arise due to changes in fundamental cell processes like migration, proliferation, differentiation and cell death driven by genetic programs. Signaling between fibroblast growt...

    Authors: Susan M Motch Perrine, Theodore M Cole III, Neus Martínez-Abadías, Kristina Aldridge, Ethylin Wang Jabs and Joan T Richtsmeier

    Citation: BMC Developmental Biology 2014 14:8

    Content type: Research article

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  42. The development of blood flow in the heart is crucial for heart function and embryonic survival. Recent studies have revealed the importance of the extracellular matrix and the mechanical stress applied to the...

    Authors: Tomomi Watanabe-Asaka, Yoshio Sekiya, Hironori Wada, Takako Yasuda, Ikuya Okubo, Shoji Oda and Hiroshi Mitani

    Citation: BMC Developmental Biology 2014 14:12

    Content type: Research article

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