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  1. All animals have mechanisms for healing damage to the epithelial sheets that cover the body and line internal cavities. Epithelial wounds heal either by cells crawling over the wound gap, by contraction of a s...

    Authors: Zach Kamran, Katie Zellner, Harry Kyriazes, Christine M. Kraus, Jean-Baptiste Reynier and Jocelyn E. Malamy

    Citation: BMC Developmental Biology 2017 17:17

    Content type: Research article

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  2. Over one third of all animal phyla utilize a mode of early embryogenesis called ‘spiral cleavage’ to divide the fertilized egg into embryonic cells with different cell fates. This mode is characterized by a se...

    Authors: Aron B. Nakama, Hsien-Chao Chou and Stephan Q. Schneider

    Citation: BMC Developmental Biology 2017 17:16

    Content type: Research article

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  3. The Midas cichlid species complex (Amphilophus spp.) is widely known among evolutionary biologists as a model system for sympatric speciation and adaptive phenotypic divergence within extremely short periods of t...

    Authors: Claudius F. Kratochwil, Maggie M. Sefton, Yipeng Liang and Axel Meyer

    Citation: BMC Developmental Biology 2017 17:15

    Content type: Methodology article

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  4. The Runt-related transcription factors (Runx) are a family of evolutionarily conserved transcriptional regulators that play multiple roles in the developmental control of various cell types. Among the three ma...

    Authors: Sebastian Nieke, Nighat Yasmin, Kiyokazu Kakugawa, Tomomasa Yokomizo, Sawako Muroi and Ichiro Taniuchi

    Citation: BMC Developmental Biology 2017 17:14

    Content type: Research article

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  5. Vertebrate head development depends on a series of interactions between many cell populations of distinct embryological origins. Cranial mesenchymal tissues have a dual embryonic source: - the neural crest (NC...

    Authors: Barbara F. Fonseca, Gérard Couly and Elisabeth Dupin

    Citation: BMC Developmental Biology 2017 17:13

    Content type: Research article

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  6. The quality and yield of duck feathers are very important economic traits that might be controlled by miRNA regulation. The aim of the present study was to investigate the mechanism underlying the crosstalk be...

    Authors: Xingyong Chen, Kai Ge, Min Wang, Cheng Zhang and Zhaoyu Geng

    Citation: BMC Developmental Biology 2017 17:12

    Content type: Research article

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  7. The identification of DNA methyltransferases (Dnmt) expression patterns during development and their regulation is important to understand the epigenetic mechanisms that modulate larval plasticity in marine fi...

    Authors: Joana Firmino, Carlos Carballo, Paula Armesto, Marco A. Campinho, Deborah M. Power and Manuel Manchado

    Citation: BMC Developmental Biology 2017 17:11

    Content type: Research article

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  8. Cathepsin B is a lysosomal cysteine protease involved in apoptosis and oocytes which have lower developmental competence show higher expression of Cathepsin B. Furthermore, expression of Cathepsin B show a dec...

    Authors: M. Pezhman, S. M. Hosseini, S. Ostadhosseini, Sh. Rouhollahi Varnosfaderani, F. Sefid and M. H. Nasr-Esfahani

    Citation: BMC Developmental Biology 2017 17:10

    Content type: Research article

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  9. Mitochondrial alternative respiratory-chain enzymes are phylogenetically widespread, and buffer stresses affecting oxidative phosphorylation in species that possess them. However, they have been lost in the ev...

    Authors: Sina Saari, Ana Andjelković, Geovana S. Garcia, Howard T. Jacobs and Marcos T. Oliveira

    Citation: BMC Developmental Biology 2017 17:9

    Content type: Research article

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  10. The tauGFP reporter fusion protein is produced nearly ubiquitously by the TgTP6.3 transgene in TP6.3 mice and its localisation to microtubules offers some advantages over soluble GFP as a lineage marker. However,...

    Authors: Linda Sharp, Thomas Pratt, Gillian E. MacKay, Margaret A. Keighren, Jean H. Flockhart, Emma J. Chandler, David J. Price, John O. Mason and John D. West

    Citation: BMC Developmental Biology 2017 17:8

    Content type: Research article

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  11. Loss of proprotein convertase subtilisin/kexin type 5 (Pcsk5) results in multiple developmental anomalies including cardiac malformations, caudal regression, pre-sacral mass, renal agenesis, anteroposterior patte...

    Authors: Dorota Szumska, Milena Cioroch, Angela Keeling, Annik Prat, Nabil G. Seidah and Shoumo Bhattacharya

    Citation: BMC Developmental Biology 2017 17:6

    Content type: Research article

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  12. Cranial neural crest cells (NCCs) are a unique embryonic cell type which give rise to a diverse array of derivatives extending from neurons and glia through to bone and cartilage. Depending on their point of o...

    Authors: Rachael Lumb, Sam Buckberry, Genevieve Secker, David Lawrence and Quenten Schwarz

    Citation: BMC Developmental Biology 2017 17:5

    Content type: Research article

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  13. The molecular mechanisms underlying the development of the unusual echinoderm pentameral body plan and their likeness to mechanisms underlying the development of the bilateral plans of other deuterostomes are ...

    Authors: Demian Koop, Paula Cisternas, Valerie B. Morris, Dario Strbenac, Jean Yee Hwa Yang, Gregory A. Wray and Maria Byrne

    Citation: BMC Developmental Biology 2017 17:4

    Content type: Research article

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  14. Lake Malawi cichlids represent one of a growing number of vertebrate models used to uncover the genetic and developmental basis of trait diversity. Rapid evolutionary radiation has resulted in species that sha...

    Authors: R. F. Bloomquist, T. E. Fowler, J. B. Sylvester, R. J. Miro and J. T. Streelman

    Citation: BMC Developmental Biology 2017 17:3

    Content type: Research article

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  15. Many parasites regulate their development to synchronize their life cycle with a compatible host. The parasitic nematode Heterodera glycines displays incomplete host-mediated hatching behavior wherein some H. gly...

    Authors: Sita Thapa, Jayna A. Patel, Ursula Reuter-Carlson and Nathan E. Schroeder

    Citation: BMC Developmental Biology 2017 17:2

    Content type: Research article

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  16. Thus far, a handful of genes have been shown to be related to the wing maturation process in insects. A novel heme peroxidase enzyme known as curly suppressor (Cysu)(formerly CG5873), have been characterized i...

    Authors: Dondra Bailey, Mohammed Abul Basar, Sanjay Nag, Nivedita Bondhu, Shaloei Teng and Atanu Duttaroy

    Citation: BMC Developmental Biology 2017 17:1

    Content type: Research article

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  17. An increase in the activity of the pituitary-gonad axis (PG-axis) and gonad development are essential for the onset of spawning migration in teleosts. In the fish Coilia nasus, gonad development and spawning migr...

    Authors: Jin-Rong Duan, Di-An Fang, Min-Ying Zhang, Kai Liu, Yan-Feng Zhou, Dong-Po Xu, Pao Xu and Da-Peng Li

    Citation: BMC Developmental Biology 2016 16:42

    Content type: Research article

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  18. Long non-coding RNAs (LncRNAs) have been identified to play important roles in epigenetic processes that underpin organogenesis. However, the role of LncRNAs in the regulation of transition from fetal to adult...

    Authors: Jue Wang, Zhimin Geng, Jiakan Weng, Longjie Shen, Ming Li, Xueli Cai, Chengchao Sun and Maoping Chu

    Citation: BMC Developmental Biology 2016 16:41

    Content type: Research article

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  19. Establishment of the left-right axis is important for positioning organs asymmetrically in the developing vertebrate-embryo. A number of factors like maternally deposited molecules have emerged essential in in...

    Authors: Kartik Gupta, Vijaya Satish Sekhar Pilli and Gopala Krishna Aradhyam

    Citation: BMC Developmental Biology 2016 16:39

    Content type: Research article

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  20. Because ribosomes are ubiquitously required for protein production, it was long assumed that any inherited defect in ribosome manufacture would be embryonically lethal. However, several human congenital diseas...

    Authors: Andrew Robson, Nick D. L. Owens, Susan J. Baserga, Mustafa K. Khokha and John N. Griffin

    Citation: BMC Developmental Biology 2016 16:38

    Content type: Research article

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  21. Increased apposition of the frontal and parietal bones of the skull during embryogenesis may be a risk factor for the subsequent development of premature skull fusion, or craniosynostosis. Human craniosynostos...

    Authors: Stephen J. Goldie, Benedicta D. Arhatari, Peter Anderson, Alana Auden, Darren D. Partridge, Stephen M. Jane and Sebastian Dworkin

    Citation: BMC Developmental Biology 2016 16:37

    Content type: Research article

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  22. Successful development of iSCNT (interspecies somatic cell nuclear transfer) embryos depends on complex interactions between ooplasmic and nuclear components, which can be compromised by genetic divergence. Tr...

    Authors: L. Antonio González-Grajales, Laura A. Favetta, W. Allan King and Gabriela F. Mastromonaco

    Citation: BMC Developmental Biology 2016 16:36

    Content type: Research article

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  23. The multicellular volvocine alga Pleodorina is intermediate in organismal complexity between its unicellular relative, Chlamydomonas, and its multicellular relative, Volvox, which shows complete division of labor...

    Authors: Stephanie Höhn and Armin Hallmann

    Citation: BMC Developmental Biology 2016 16:35

    Content type: Research article

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  24. Bone morphogenetic protein (BMP) signalling has emerged as a fundamental pathway in endothelial cell biology and deregulation of this pathway is implicated in several vascular disorders. BMP signalling output ...

    Authors: Karen Beets, Michael W. Staring, Nathan Criem, Elke Maas, Niels Schellinx, Susana M. Chuva de Sousa Lopes, Lieve Umans and An Zwijsen

    Citation: BMC Developmental Biology 2016 16:34

    Content type: Research article

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  25. Nuclear receptors are a highly conserved set of ligand binding transcription factors, with essential roles regulating aspects of vertebrate and invertebrate biology alike. Current understanding of nuclear rece...

    Authors: Susanne Vogeler, Tim P. Bean, Brett P. Lyons and Tamara S. Galloway

    Citation: BMC Developmental Biology 2016 16:33

    Content type: Research article

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  26. Nuclear Factor-Kappa B (NF-kB) is a family of transcription factors that are important in embryonic development, inflammation, epithelial-to-mesenchymal transition and cancer. The 65 kDa RelA subunit is the ma...

    Authors: Talha Ijaz, Maki Wakamiya, Hong Sun, Adrian Recinos III, Ronald G. Tilton and Allan R. Brasier

    Citation: BMC Developmental Biology 2016 16:32

    Content type: Methodology article

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  27. HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 (HACE1) regulates a wide variety of cellular processes. It has been shown that one of the targets of HACE1 is the GTP-bound form of the s...

    Authors: Akira Iimura, Fuhito Yamazaki, Toshiyasu Suzuki, Tatsuya Endo, Eisuke Nishida and Morioh Kusakabe

    Citation: BMC Developmental Biology 2016 16:31

    Content type: Research article

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  28. Wnt11 is a member of the Wnt family of secreted signals controlling the early steps in ureteric bud (UB) branching. Due to the reported lethality of Wnt11 knockout embryos in utero, its role in later mammalian ki...

    Authors: Irina I. Nagy, Qi Xu, Florence Naillat, Nsrein Ali, Ilkka Miinalainen, Anatoly Samoylenko and Seppo J. Vainio

    Citation: BMC Developmental Biology 2016 16:30

    Content type: Research article

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  29. Authors: Daniel Silberschmidt, Alina Rodriguez-Mallon, Prathiba Mithboakar, Gaetano Calì, Elena Amendola, Remo Sanges, Mariastella Zannini, Marzia Scarfò, Pasquale De Luca, Lucio Nitsch, Roberto Di Lauro and Mario De Felice

    Citation: BMC Developmental Biology 2016 16:29

    Content type: Erratum

    Published on:

    The original article was published in BMC Developmental Biology 2011 11:9

  30. Left-right (LR) organ asymmetries are a common feature of metazoan animals. In many cases, laterality is established by a conserved asymmetric Nodal signaling cascade during embryogenesis. In most vertebrates,...

    Authors: Matthias Tisler, Franziska Wetzel, Sabrina Mantino, Stanislav Kremnyov, Thomas Thumberger, Axel Schweickert, Martin Blum and Philipp Vick

    Citation: BMC Developmental Biology 2016 16:28

    Content type: Research article

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  31. The Hedgehog (HH) signalling pathway regulates cardiomyogenesis in vivo and in differentiating P19 embryonal carcinoma (EC) cells, a mouse embryonic stem (mES) cell model. To further assess the transcriptional...

    Authors: Joel Vincent Fair, Anastassia Voronova, Neven Bosiljcic, Rashida Rajgara, Alexandre Blais and Ilona Sylvia Skerjanc

    Citation: BMC Developmental Biology 2016 16:27

    Content type: Research article

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  32. Myostatin (MSTN) encodes a negative regulator of skeletal muscle mass that might have applications for promoting muscle growth in livestock. In this study, we aimed to test whether tar...

    Authors: Baoli Yu, Rui Lu, Yuguo Yuan, Ting Zhang, Shaozheng Song, Zhengqiang Qi, Bin Shao, Mengmin Zhu, Fei Mi and Yong Cheng

    Citation: BMC Developmental Biology 2016 16:26

    Content type: Research article

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  33. There is a gap in knowledge regarding the cardiovascular system in fish conjoined twins, and regarding the cardiovascular morphogenesis of conjoined twins in general. We examined the cardiovascular system in a...

    Authors: Per Gunnar Fjelldal, Monica F. Solberg, Tom Hansen, Tone Vågseth, Kevin Alan Glover and Harald Kryvi

    Citation: BMC Developmental Biology 2016 16:25

    Content type: Research article

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  34. Ion-transport mechanisms and gap junctions are known to cooperate in creating bioelectric phenomena, like pH gradients, voltage gradients and ion fluxes within single cells, tissues, organs, and whole organism...

    Authors: Julia Lautemann and Johannes Bohrmann

    Citation: BMC Developmental Biology 2016 16:24

    Content type: Research article

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  35. Birt-Hogg-Dubé syndrome (BHD) is a dominantly inherited familial cancer syndrome characterised by the development of benign skin fibrofolliculomas, multiple lung and kidney cysts, spontaneous pneumothorax and ...

    Authors: Emma J. Kenyon, Monique N. H. Luijten, Harmeet Gill, Nan Li, Matthew Rawlings, James C. Bull, Yavor Hadzhiev, Maurice A. M. van Steensel, Eamonn Maher and Ferenc Mueller

    Citation: BMC Developmental Biology 2016 16:23

    Content type: Research article

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  36. Selective plane illumination microscopy (SPIM a type of light-sheet microscopy) involves focusing a thin sheet of laser light through a specimen at right angles to the objective lens. As only the thin section ...

    Authors: Johannes Girstmair, Anne Zakrzewski, François Lapraz, Mette Handberg-Thorsager, Pavel Tomancak, Peter Gabriel Pitrone, Fraser Simpson and Maximilian J. Telford

    Citation: BMC Developmental Biology 2016 16:22

    Content type: Methodology article

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  37. Current knowledge of the human fetal and embryonic development relies on early descriptive studies of humans and from experimental studies of laboratory animals and embryos. Taking the upper extremity as an ex...

    Authors: Inga Langner, Thomas Stahnke, Oliver Stachs, Tobias Lindner, Jens-Peter Kühn, Simon Kim, Andreas Wree and Soenke Langner

    Citation: BMC Developmental Biology 2016 16:21

    Content type: Research article

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  38. Flatworms possess pluripotent stem cells that can give rise to all cell types, which allows them to restore lost body parts after injury or amputation. This makes flatworms excellent model systems for studying...

    Authors: Birgit Lengerer, Elise Hennebert, Patrick Flammang, Willi Salvenmoser and Peter Ladurner

    Citation: BMC Developmental Biology 2016 16:20

    Content type: Research article

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  39. Definitive endoderm (DE) gives rise to the respiratory apparatus and digestive tract. Sox17 and Cxcr4 are useful markers of the DE. Previously, we identified a novel DE marker, Decay accelerating factor 1(Daf1...

    Authors: Soichiro Ogaki, Hisayoshi Omori, Mayu Morooka, Nobuaki Shiraki, Seiichi Ishida and Shoen Kume

    Citation: BMC Developmental Biology 2016 16:19

    Content type: Research article

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  40. The pituitary gland is a highly vascularized tissue that requires coordinated interactions between the neural ectoderm, oral ectoderm, and head mesenchyme during development for proper physiological function. ...

    Authors: Shannon W. Davis, Amanda H. Mortensen, Jessica L. Keisler, Amanda L. Zacharias, Philip J. Gage, Ken-ichi Yamamura and Sally A. Camper

    Citation: BMC Developmental Biology 2016 16:16

    Content type: Research article

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  41. Insect metamorphosis relies on temporal and spatial cues that are precisely controlled. Previous studies in Drosophila have shown that untimely activation of genes that are essential to metamorphosis results in g...

    Authors: Kimberly Regna, Peri T. Kurshan, Benjamin N. Harwood, Adam M. Jenkins, Chao-Qiang Lai, Marc A.T. Muskavitch, Alan S. Kopin and Isabelle Draper

    Citation: BMC Developmental Biology 2016 16:15

    Content type: Research article

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  42. Wnt5a and Mrfzb1 genes are involved in the regulation of tooth size, and their expression levels are similar to that of Bmp7 during morphogenesis, including during the cap and early be...

    Authors: Kazuyuki Saito, Katsu Takahashi, Masakazu Asahara, Honoka Kiso, Yumiko Togo, Hiroko Tsukamoto, Boyen Huang, Manabu Sugai, Akira Shimizu, Masaharu Motokawa, Harold C. Slavkin and Kazuhisa Bessho

    Citation: BMC Developmental Biology 2016 16:14

    Content type: Research article

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  43. During early development of the nervous system, gene expression patterns are known to vary widely depending on the specific developmental trajectories of different structures. Observable changes in gene expres...

    Authors: Jimena Monzón-Sandoval, Atahualpa Castillo-Morales, Araxi O. Urrutia and Humberto Gutierrez

    Citation: BMC Developmental Biology 2016 16:13

    Content type: Research article

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  44. The contribution of programmed cell death (PCD) to muscle wasting disorders remains a matter of debate. Drosophila melanogaster metamorphosis offers the opportunity to study muscle cell death in the context of de...

    Authors: Yadav Kuleesha, Wee Choo Puah and Martin Wasser

    Citation: BMC Developmental Biology 2016 16:12

    Content type: Research article

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  45. We previously reported that the pluripotent stem cells can differentiate into cardiomyocytes (CMs) by co-culture with neonatal CMs (NCMs) in vitro. However, the involving mechanism is not clear.

    Authors: Dongbo Ou, Qi Wang, Yanjin Huang, Di Zeng, Ting Wei, Lu Ding, Xiaoli Li, Qiangsun Zheng and Yan Jin

    Citation: BMC Developmental Biology 2016 16:11

    Content type: Research article

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  46. Detailed descriptions of the early development of parasitic nematodes are seldom available. The embryonic development of the plant-parasitic nematode Meloidogyne incognita was studied, focusing on the early event...

    Authors: Alejandro Calderón-Urrea, Bartel Vanholme, Sandra Vangestel, Saben M. Kane, Abdellatif Bahaji, Khavong Pha, Miguel Garcia, Alyssa Snider and Godelieve Gheysen

    Citation: BMC Developmental Biology 2016 16:10

    Content type: Research article

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