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  1. Research article

    Cilia are required for asymmetric nodal induction in the sea urchin embryo

    Left-right (LR) organ asymmetries are a common feature of metazoan animals. In many cases, laterality is established by a conserved asymmetric Nodal signaling cascade during embryogenesis. In most vertebrates,...

    Matthias Tisler, Franziska Wetzel, Sabrina Mantino, Stanislav Kremnyov, Thomas Thumberger, Axel Schweickert, Martin Blum and Philipp Vick

    BMC Developmental Biology 2016 16:28

    Published on: 23 August 2016

  2. Research article

    BRG1 interacts with GLI2 and binds Mef2c gene in a hedgehog signalling dependent manner during in vitro cardiomyogenesis

    The Hedgehog (HH) signalling pathway regulates cardiomyogenesis in vivo and in differentiating P19 embryonal carcinoma (EC) cells, a mouse embryonic stem (mES) cell model. To further assess the transcriptional...

    Joel Vincent Fair, Anastassia Voronova, Neven Bosiljcic, Rashida Rajgara, Alexandre Blais and Ilona Sylvia Skerjanc

    BMC Developmental Biology 2016 16:27

    Published on: 2 August 2016

  3. Research article

    Efficient TALEN-mediated myostatin gene editing in goats

    Myostatin (MSTN) encodes a negative regulator of skeletal muscle mass that might have applications for promoting muscle growth in livestock. In this study, we aimed to test whether tar...

    Baoli Yu, Rui Lu, Yuguo Yuan, Ting Zhang, Shaozheng Song, Zhengqiang Qi, Bin Shao, Mengmin Zhu, Fei Mi and Yong Cheng

    BMC Developmental Biology 2016 16:26

    Published on: 27 July 2016

  4. Research article

    Salmonid fish: model organisms to study cardiovascular morphogenesis in conjoined twins?

    There is a gap in knowledge regarding the cardiovascular system in fish conjoined twins, and regarding the cardiovascular morphogenesis of conjoined twins in general. We examined the cardiovascular system in a...

    Per Gunnar Fjelldal, Monica F. Solberg, Tom Hansen, Tone Vågseth, Kevin Alan Glover and Harald Kryvi

    BMC Developmental Biology 2016 16:25

    Published on: 16 July 2016

  5. Research article

    Relating proton pumps with gap junctions: colocalization of ductin, the channel-forming subunit c of V-ATPase, with subunit a and with innexins 2 and 3 during Drosophila oogenesis

    Ion-transport mechanisms and gap junctions are known to cooperate in creating bioelectric phenomena, like pH gradients, voltage gradients and ion fluxes within single cells, tissues, organs, and whole organism...

    Julia Lautemann and Johannes Bohrmann

    BMC Developmental Biology 2016 16:24

    Published on: 13 July 2016

  6. Research article

    Expression and knockdown of zebrafish folliculin suggests requirement for embryonic brain morphogenesis

    Birt-Hogg-Dubé syndrome (BHD) is a dominantly inherited familial cancer syndrome characterised by the development of benign skin fibrofolliculomas, multiple lung and kidney cysts, spontaneous pneumothorax and ...

    Emma J. Kenyon, Monique N. H. Luijten, Harmeet Gill, Nan Li, Matthew Rawlings, James C. Bull, Yavor Hadzhiev, Maurice A. M. van Steensel, Eamonn Maher and Ferenc Mueller

    BMC Developmental Biology 2016 16:23

    Published on: 8 July 2016

  7. Methodology article

    Light-sheet microscopy for everyone? Experience of building an OpenSPIM to study flatworm development

    Selective plane illumination microscopy (SPIM a type of light-sheet microscopy) involves focusing a thin sheet of laser light through a specimen at right angles to the objective lens. As only the thin section ...

    Johannes Girstmair, Anne Zakrzewski, François Lapraz, Mette Handberg-Thorsager, Pavel Tomancak, Peter Gabriel Pitrone, Fraser Simpson and Maximilian J. Telford

    BMC Developmental Biology 2016 16:22

    Published on: 30 June 2016

  8. Research article

    MR microscopy of the human fetal upper extremity – a proof-of-principle study

    Current knowledge of the human fetal and embryonic development relies on early descriptive studies of humans and from experimental studies of laboratory animals and embryos. Taking the upper extremity as an ex...

    Inga Langner, Thomas Stahnke, Oliver Stachs, Tobias Lindner, Jens-Peter Kühn, Simon Kim, Andreas Wree and Soenke Langner

    BMC Developmental Biology 2016 16:21

    Published on: 18 June 2016

  9. Research article

    Adhesive organ regeneration in Macrostomum lignano

    Flatworms possess pluripotent stem cells that can give rise to all cell types, which allows them to restore lost body parts after injury or amputation. This makes flatworms excellent model systems for studying...

    Birgit Lengerer, Elise Hennebert, Patrick Flammang, Willi Salvenmoser and Peter Ladurner

    BMC Developmental Biology 2016 16:20

    Published on: 2 June 2016

  10. Research article

    Late stage definitive endodermal differentiation can be defined by Daf1 expression

    Definitive endoderm (DE) gives rise to the respiratory apparatus and digestive tract. Sox17 and Cxcr4 are useful markers of the DE. Previously, we identified a novel DE marker, Decay accelerating factor 1(Daf1...

    Soichiro Ogaki, Hisayoshi Omori, Mayu Morooka, Nobuaki Shiraki, Seiichi Ishida and Shoen Kume

    BMC Developmental Biology 2016 16:19

    Published on: 31 May 2016

  11. Research article

    β-catenin is required in the neural crest and mesencephalon for pituitary gland organogenesis

    The pituitary gland is a highly vascularized tissue that requires coordinated interactions between the neural ectoderm, oral ectoderm, and head mesenchyme during development for proper physiological function. ...

    Shannon W. Davis, Amanda H. Mortensen, Jessica L. Keisler, Amanda L. Zacharias, Philip J. Gage, Ken-ichi Yamamura and Sally A. Camper

    BMC Developmental Biology 2016 16:16

    Published on: 16 May 2016

  12. Research article

    A critical role for the Drosophila dopamine D1-like receptor Dop1R2 at the onset of metamorphosis

    Insect metamorphosis relies on temporal and spatial cues that are precisely controlled. Previous studies in Drosophila have shown that untimely activation of genes that are essential to metamorphosis results in g...

    Kimberly Regna, Peri T. Kurshan, Benjamin N. Harwood, Adam M. Jenkins, Chao-Qiang Lai, Marc A.T. Muskavitch, Alan S. Kopin and Isabelle Draper

    BMC Developmental Biology 2016 16:15

    Published on: 16 May 2016

  13. Research article

    Effects of Usag-1 and Bmp7 deficiencies on murine tooth morphogenesis

    Wnt5a and Mrfzb1 genes are involved in the regulation of tooth size, and their expression levels are similar to that of Bmp7 during morphogenesis, including during the cap and early be...

    Kazuyuki Saito, Katsu Takahashi, Masakazu Asahara, Honoka Kiso, Yumiko Togo, Hiroko Tsukamoto, Boyen Huang, Manabu Sugai, Akira Shimizu, Masaharu Motokawa, Harold C. Slavkin and Kazuhisa Bessho

    BMC Developmental Biology 2016 16:14

    Published on: 13 May 2016

  14. Research article

    Modular reorganization of the global network of gene regulatory interactions during perinatal human brain development

    During early development of the nervous system, gene expression patterns are known to vary widely depending on the specific developmental trajectories of different structures. Observable changes in gene expres...

    Jimena Monzón-Sandoval, Atahualpa Castillo-Morales, Araxi O. Urrutia and Humberto Gutierrez

    BMC Developmental Biology 2016 16:13

    Published on: 12 May 2016

  15. Research article

    Live imaging of muscle histolysis in Drosophila metamorphosis

    The contribution of programmed cell death (PCD) to muscle wasting disorders remains a matter of debate. Drosophila melanogaster metamorphosis offers the opportunity to study muscle cell death in the context of de...

    Yadav Kuleesha, Wee Choo Puah and Martin Wasser

    BMC Developmental Biology 2016 16:12

    Published on: 4 May 2016

  16. Research article

    Co-culture with neonatal cardiomyocytes enhances the proliferation of iPSC-derived cardiomyocytes via FAK/JNK signaling

    We previously reported that the pluripotent stem cells can differentiate into cardiomyocytes (CMs) by co-culture with neonatal CMs (NCMs) in vitro. However, the involving mechanism is not clear.

    Dongbo Ou, Qi Wang, Yanjin Huang, Di Zeng, Ting Wei, Lu Ding, Xiaoli Li, Qiangsun Zheng and Yan Jin

    BMC Developmental Biology 2016 16:11

    Published on: 4 May 2016

  17. Research article

    Early development of the root-knot nematode Meloidogyne incognita

    Detailed descriptions of the early development of parasitic nematodes are seldom available. The embryonic development of the plant-parasitic nematode Meloidogyne incognita was studied, focusing on the early event...

    Alejandro Calderón-Urrea, Bartel Vanholme, Sandra Vangestel, Saben M. Kane, Abdellatif Bahaji, Khavong Pha, Miguel Garcia, Alyssa Snider and Godelieve Gheysen

    BMC Developmental Biology 2016 16:10

    Published on: 28 April 2016

  18. Research article

    The combined effect of PDX1, epidermal growth factor and poly-L-ornithine on human amnion epithelial cells’ differentiation

    It has been suggested that the ectopic expression of PDX1, a dominant pancreatic transcription factor, plays a critical role in the developmental programming of the pancreas even from cells of unrelated tissue...

    Shruti Balaji, Yu Zhou, Anasuya Ganguly, Emmanuel C. Opara and Shay Soker

    BMC Developmental Biology 2016 16:8

    Published on: 12 April 2016

  19. Research article

    Apontic regulates somatic stem cell numbers in Drosophila testes

    Microenvironments called niches maintain resident stem cell populations by balancing self-renewal with differentiation, but the genetic regulation of this process is unclear. The niche of the Drosophila testis...

    Amanda J. Monahan and Michelle Starz-Gaiano

    BMC Developmental Biology 2016 16:5

    Published on: 18 March 2016

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