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  1. Developmentally important genes often result in early lethality in knockout animals. Thus, the direct role of genes in late gestation organogenesis cannot be assessed directly. In utero delivery of transgenes was...

    Authors: J Craig Cohen, Donald K Scott, James Miller, Jianxuan Zhang, Pengbo Zhou and Janet E Larson

    Citation: BMC Developmental Biology 2004 4:4

    Content type: Research article

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  2. In mice, germ cells are specified through signalling between layers of cells comprising the primitive embryo. The function of Dppa3 (also known as Pgc7 or stella), a gene expressed in primordial germ cells at the...

    Authors: Alex Bortvin, Mary Goodheart, Michelle Liao and David C Page

    Citation: BMC Developmental Biology 2004 4:2

    Content type: Research article

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  3. Normal post-squalene cholesterol biosynthesis is important for mammalian embryonic development. Neonatal mice lacking functional dehydrocholesterol Δ7-reductase (Dhcr7), a model for the human disease of Smith-...

    Authors: Hongwei Yu, Andy Wessels, Jianliang Chen, Aimee L Phelps, John Oatis, G Stephen Tint and Shailendra B Patel

    Citation: BMC Developmental Biology 2004 4:1

    Content type: Research article

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  4. Fertilization in Caenorhabditis elegans requires functional SPE-9 protein in sperm. SPE-9 is a transmembrane protein with a predicted extracellular domain that contains ten epidermal growth factor (EGF)-like moti...

    Authors: Sonia Zannoni, Steven W L'Hernault and Andrew W Singson

    Citation: BMC Developmental Biology 2003 3:10

    Content type: Research article

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  5. In addition to their strong induction following stress, small heat shock proteins (Hsp) are also expressed during development in a wide variety of organisms. However, the precise identity of cell(s) expressing...

    Authors: Sébastien Michaud and Robert M Tanguay

    Citation: BMC Developmental Biology 2003 3:9

    Content type: Research article

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  6. Cell polarity is essential for many decisions made during development. While investigation of polarity-specific factors has yielded great insights into the polarization process, little is known on how these po...

    Authors: Chad A Rappleye, Akiko Tagawa, Nathalie Le Bot, Julie Ahringer and Raffi V Aroian

    Citation: BMC Developmental Biology 2003 3:8

    Content type: Research article

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  7. Many insects undergo a period of arrested development, called diapause, to avoid seasonally recurring adverse conditions. Whilst the phenology and endocrinology of insect diapause have been well studied, there...

    Authors: Alexander W Shingleton, Geoffroy C Sisk and David L Stern

    Citation: BMC Developmental Biology 2003 3:7

    Content type: Research article

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  8. Folate is essential for cellular proliferation and tissue regeneration. As mammalian cells cannot synthesize folates de novo, tightly regulated cellular uptake processes have evolved to sustain sufficient levels ...

    Authors: Dennis M Maddox, Anna Manlapat, Penny Roon, Puttur Prasad, Vadivel Ganapathy and Sylvia B Smith

    Citation: BMC Developmental Biology 2003 3:6

    Content type: Research article

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  9. The transition from growth to development in Dictyostelium is initiated by amino acid starvation of growing amobae. In other eukaryotes, a key sensor of amino acid starvation and mediator of the resulting physiol...

    Authors: Rui Fang, Yanhua Xiong and Charles K Singleton

    Citation: BMC Developmental Biology 2003 3:3

    Content type: Research article

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  10. The Wnt signal transduction pathway is important in a wide variety of developmental processes as well as in the genesis of human cancer. Vertebrate Wnt pathways can be functionally separated into two classes, ...

    Authors: Mary G Prieve and Randall T Moon

    Citation: BMC Developmental Biology 2003 3:2

    Content type: Research article

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  11. Specification of primordial germ cells in mice depends on instructive signalling events, which act first to confer germ cell competence on epiblast cells, and second, to impose a germ cell fate upon competent ...

    Authors: UC Lange, M Saitou, PS Western, SC Barton and MA Surani

    Citation: BMC Developmental Biology 2003 3:1

    Content type: Research article

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  12. The spadetail (spt) gene of zebrafish is expressed in presomitic mesoderm and in neural cells previously suggested to be Rohon-Beard neurons. The mechanism(s) generating the apparently irregular rostrocaudal dist...

    Authors: Richard Tamme, Simon Wells, John G Conran and Michael Lardelli

    Citation: BMC Developmental Biology 2002 2:9

    Content type: Research article

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  13. Trophoblast migration into maternal decidua is essential for normal pregnancy. It occurs in a defined time window, is spatially highly restricted, and is aberrant in some pathological pregnancies, but the cont...

    Authors: Helen Lacey, Teresa Haigh, Melissa Westwood and John D Aplin

    Citation: BMC Developmental Biology 2002 2:5

    Content type: Research article

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  14. Hedgehog signaling proteins play important roles in development by controlling growth and patterning in various animals including Drosophila and mammals. Hedgehog signaling triggers changes in responsive cells...

    Authors: Véronique Monnier, Karen S Ho, Matthieu Sanial, Matthew P Scott and Anne Plessis

    Citation: BMC Developmental Biology 2002 2:4

    Content type: Research article

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  15. The Rel/NF-κB transcription factors have been shown to regulate apoptosis in different cell types, acting as inducers or blockers in a stimuli- and cell type-dependent fashion. One of the Rel/NF-κB subunits, R...

    Authors: Arkady Torchinsky, Lucy Lishanski, Orit Wolstein, Jeanne Shepshelovich, Hasida Orenstein, Shoshana Savion, Zeev Zaslavsky, Howard Carp, Alexander Brill, Rivka Dikstein, Vladimir Toder and Amos Fein

    Citation: BMC Developmental Biology 2002 2:2

    Content type: Research article

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  16. Mechanisms regulating neuronal migration during development remain largely undefined. Extracellular matrix cues, target site released factors, and components of the migratory neurons themselves are likely all ...

    Authors: Paola T Drapkin, Denis Monard and Ann-Judith Silverman

    Citation: BMC Developmental Biology 2002 2:1

    Content type: Research article

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  17. The proper balance between epithelial cell proliferation, quiescence, and apoptosis during development is mediated by the specific temporal and spatial appearance of transcription factors, growth factors, cyto...

    Authors: Michael Melnick, Haiming Chen, Yan Min Zhou and Tina Jaskoll

    Citation: BMC Developmental Biology 2001 1:15

    Content type: Research article

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  18. In vitro maturation of mammalian oocytes is an area of great interest due to its potential application in the treatment of infertility. The morphological and physiological changes that occur during oocyte deve...

    Authors: Benjamin R Emery, Raymond L Miller and Douglas T Carrell

    Citation: BMC Developmental Biology 2001 1:14

    Content type: Research article

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  19. Many cloned animals have been created by transfer of differentiated cells at G0/G1 or M phase of the cell cycle into enucleated M II oocytes having high maturation/meiosis/mitosis-promoting factor activity. Be...

    Authors: Kazuchika Miyoshi, S Jacek Rzucidlo, John R Gibbons, Sezen Arat and Steven L Stice

    Citation: BMC Developmental Biology 2001 1:12

    Content type: Research article

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  20. Mesenchymal-epithelial interactions play an important role in the physiology and pathology of epithelial tissues. Mesenchymal cells either associate with epithelium basement membrane [pericytes and perivascula...

    Authors: Antonin Bukovsky, Michael R Caudle, Jeffrey A Keenan, Nirmala B Upadhyaya, Stuart E Van Meter, Jay Wimalasena and Robert F Elder

    Citation: BMC Developmental Biology 2001 1:11

    Content type: Research article

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  21. Expression of transgenes in mice requires transcriptional regulatory elements that direct expression in a chosen cell type. Unfortunately, the availability of well-characterized promoters that direct bona-fide...

    Authors: Roong Zhao, Scott A Fahs, Hartmut Weiler and Stephen A Duncan

    Citation: BMC Developmental Biology 2001 1:10

    Content type: Methodology article

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  22. Nocturnin was originally identified by differential display as a circadian clock regulated gene with high expression at night in photoreceptors of the African clawed frog, Xenopus laevis. Although encoding a nove...

    Authors: Yunxia Wang, David L Osterbur, Pamela L Megaw, Gianluca Tosini, Chiaki Fukuhara, Carla B Green and Joseph C Besharse

    Citation: BMC Developmental Biology 2001 1:9

    Content type: Research article

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  23. Of the animals typically used to study fertilization-induced calcium dynamics, none is as accessible to genetics and molecular biology as the model organism Caenorhabditis elegans. Motivated by the experimental p...

    Authors: Aravinthan DT Samuel, Venkatesh N Murthy and Michael O Hengartner

    Citation: BMC Developmental Biology 2001 1:8

    Content type: Methodology article

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  24. Gaps exist in the modern literature that describes patterns of development in living groups of actinopterygian fishes. Relatively recent descriptions of development exist for the teleost fishes, bowfin, sturge...

    Authors: Wilbur L Long and William W Ballard

    Citation: BMC Developmental Biology 2001 1:6

    Content type: Research article

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  25. The regulation of programmed cell death is critical to developmental homeostasis and normal morphogenesis of embryonic tissues. Survivin, a member of the inhibitors of apoptosis protein (IAP) family primarily ...

    Authors: Tina Jaskoll, Haiming Chen, Yan Min Zhou, Dingwen Wu and Michael Melnick

    Citation: BMC Developmental Biology 2001 1:5

    Content type: Research article

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  26. Several Cre reporter strains of mice have been described, in which a lacZ gene is turned on in cells expressing Cre recombinase, as well as their daughter cells, following Cre-mediated excision of a loxP-flanked ...

    Authors: Shankar Srinivas, Tomoko Watanabe, Chyuan-Sheng Lin, Chris M William, Yasuto Tanabe, Thomas M Jessell and Frank Costantini

    Citation: BMC Developmental Biology 2001 1:4

    Content type: Methodology article

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  27. The iridocorneal angle forms in the mammalian eye from undifferentiated mesenchyme between the root of the iris and cornea. A major component is the trabecular meshwork, consisting of extracellular matrix orga...

    Authors: Richard S Smith, Adriana Zabaleta, Olga V Savinova and Simon WM John

    Citation: BMC Developmental Biology 2001 1:3

    Content type: Research article

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  28. The Caenorhabditis elegans gene mec-3 encodes a LIM-homeodomain protein that is a master regulator of touch receptor neuron genes. Two of the touch neurons, the ALM neurons, are generated in the anterior of the a...

    Authors: Nicole Toms, Jennifer Cooper, Brandi Patchen and Eric Aamodt

    Citation: BMC Developmental Biology 2001 1:2

    Content type: Research article

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