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  1. The pharynx of C. elegans is an epithelial tube whose development has been compared to that of the embryonic heart and the kidney and hence serves as an interesting model for organ development. Several C. elegans

    Authors: Claes Axäng, Manish Rauthan, David H Hall and Marc Pilon
    Citation: BMC Developmental Biology 2007 7:61
  2. The embryonic developmental process in avian species is quite different from that in mammals. The first cleavage begins 4 h after fertilization, but the first differentiation does not occur until laying of the...

    Authors: Bo Ram Lee, Heebal Kim, Tae Sub Park, Sunjin Moon, Seoae Cho, Taesung Park, Jeong Mook Lim and Jae Yong Han
    Citation: BMC Developmental Biology 2007 7:60
  3. In the developing embryo, total RNA abundance fluctuates caused by functional RNA degradation and zygotic genome activation. These variations in the transcriptome in early development complicate the choice of ...

    Authors: Ewart W Kuijk, Leonie du Puy, Helena TA van Tol, Henk P Haagsman, Ben Colenbrander and Bernard AJ Roelen
    Citation: BMC Developmental Biology 2007 7:58
  4. Cell-cycle-related proteins, such as cyclins or cyclin-dependent kinases, may have functions beyond that of cell cycle regulation. The expression and translocation of cyclinD1-CDK4 in post-mitotic neurons indi...

    Authors: Chenchen Li, Xinmei Li, Weiheng Chen, Shanshan Yu, Jutao Chen, Huili Wang and Diyun Ruan
    Citation: BMC Developmental Biology 2007 7:57
  5. Plexins are a large family of transmembrane receptors for the Semaphorins, known for their role in the assembly of neural circuitry. More recently, Plexins have been implicated in diverse biological functions,...

    Authors: Pietro Fazzari, Junia Penachioni, Sara Gianola, Ferdinando Rossi, Britta J Eickholt, Flavio Maina, Lena Alexopoulou, Antonino Sottile, Paolo Maria Comoglio, Richard A Flavell and Luca Tamagnone
    Citation: BMC Developmental Biology 2007 7:55
  6. During development cell migration takes place prior to differentiation of many cell types. The chemokine receptor Cxcr4 and its ligand Sdf1 are implicated in migration of several cell lineages, including appen...

    Authors: Shang-Wei Chong, Le-Minh Nguyet, Yun-Jin Jiang and Vladimir Korzh
    Citation: BMC Developmental Biology 2007 7:54
  7. Cdkn1c encodes an embryonic cyclin-dependant kinase inhibitor that acts to negatively regulate cell proliferation and, in some tissues, to actively direct differentiation. This gene, which is an imprinted gene ex...

    Authors: Stuart C Andrews, Michelle D Wood, Simon J Tunster, Sheila C Barton, M Azim Surani and Rosalind M John
    Citation: BMC Developmental Biology 2007 7:53
  8. Movement of cells, either as amoeboid individuals or in organised groups, is a key feature of organ formation. Both modes of migration occur during Drosophila embryonic gonad development, which therefore provides...

    Authors: Ivan BN Clark, Andrew P Jarman and David J Finnegan
    Citation: BMC Developmental Biology 2007 7:52
  9. Previous study has demonstrated that dietary taurine supplement protected rats from impairments of synaptic plasticity induced by postnatal lead exposure. However, little is known about the role of taurine in ...

    Authors: Shan-Shan Yu, Ming Wang, Xin-Mei Li, Wei-Heng Chen, Ju-Tao Chen, Hui-Li Wang and Di-Yun Ruan
    Citation: BMC Developmental Biology 2007 7:51
  10. Survivin is the smallest member of the inhibitor of apoptosis (IAP) gene family. Recently, the zebrafish survivin-1 gene has been cloned, showing remarkable sequence identity and similarity over the BIR domain co...

    Authors: Alvin CH Ma, Rachel Lin, Po-Kwok Chan, Joseph CK Leung, Loretta YY Chan, Anming Meng, Catherine M Verfaillie, Raymond Liang and Anskar YH Leung
    Citation: BMC Developmental Biology 2007 7:50
  11. The visceral trunk mesoderm in Drosophila melanogaster develops under inductive signals from the ectoderm. This leads to the activation of the key regulators Tinman, Bagpipe and Biniou that are crucial for specif...

    Authors: Dmitry Popichenko, Julia Sellin, Marek Bartkuhn and Achim Paululat
    Citation: BMC Developmental Biology 2007 7:49
  12. In the mouse olfactory system, the role of the olfactory bulb in guiding olfactory sensory neuron (OSN) axons to their targets is poorly understood. What cell types within the bulb are necessary for targeting ...

    Authors: Eric O Williams, Yuanyuan Xiao, Heather M Sickles, Paul Shafer, Golan Yona, Jean YH Yang and David M Lin
    Citation: BMC Developmental Biology 2007 7:48
  13. Despite their distinct origins, human embryonic stem (hES) and embryonic carcinoma (hEC) cells share a number of similarities such as surface antigen expression, growth characteristics, the ability to either s...

    Authors: Boris Greber, Hans Lehrach and James Adjaye
    Citation: BMC Developmental Biology 2007 7:46
  14. Neural precursor cells (NPCs) can be isolated from various regions of the postnatal central nervous system (CNS). Manipulation of gene expression in these cells offers a promising strategy to manipulate their ...

    Authors: Cédric G Geoffroy and Olivier Raineteau
    Citation: BMC Developmental Biology 2007 7:45
  15. The G-protein-coupled receptor (GPCR) family represents the largest and most important group of targets for chemotherapeutics. They are extremely versatile receptors that transduce signals as diverse as biogen...

    Authors: Yogikala Prabhu, Rolf Müller, Christophe Anjard and Angelika A Noegel
    Citation: BMC Developmental Biology 2007 7:44
  16. How different immune cell compartments contribute to a successful immune response is central to fully understanding the mechanisms behind normal processes such as tissue repair and the pathology of inflammator...

    Authors: Chris Hall, Maria Vega Flores, Thilo Storm, Kathy Crosier and Phil Crosier
    Citation: BMC Developmental Biology 2007 7:42
  17. In insects and in mammals, male sperm and seminal fluid provide signaling factors that influence various aspects of female physiology and behavior to promote reproductive success and to compete with other male...

    Authors: Marie McGovern, Ling Yu, Mary Kosinski, David Greenstein and Cathy Savage-Dunn
    Citation: BMC Developmental Biology 2007 7:41
  18. This report describes an unexpected aspect of the structure and development of developmental biology research, rather than the development of a specific embryo. Descriptions of modern developmental biology emp...

    Authors: Jamie A Davies
    Citation: BMC Developmental Biology 2007 7:40
  19. Rybp (Ring1 and YY1 binding protein) is a zinc finger protein which interacts with the members of the mammalian polycomb complexes. Previously we have shown that Rybp is critical for early embryogenesis and that ...

    Authors: Melinda K Pirity, Wei-Lin Wang, Louise V Wolf, Ernst R Tamm, Nicole Schreiber-Agus and Ales Cvekl
    Citation: BMC Developmental Biology 2007 7:39
  20. Normal mammalian development requires the action of DNA methyltransferases (DNMTs) for the establishment and maintenance of DNA methylation within repeat elements and imprinted genes. Here we report the expres...

    Authors: Diana Lucifero, Sophie La Salle, Déborah Bourc'his, Josée Martel, Timothy H Bestor and Jacquetta M Trasler
    Citation: BMC Developmental Biology 2007 7:36
  21. Heterodera glycines (soybean cyst nematode [SCN]), the major pathogen of Glycine max (soybean), undergoes muscle degradation (sarcopenia) as it becomes sedentary inside the root. Many genes encoding muscular and ...

    Authors: Vincent P Klink, Veronica E Martins, Nadim W Alkharouf, Christopher C Overall, Margaret H MacDonald and Benjamin F Matthews
    Citation: BMC Developmental Biology 2007 7:35
  22. The presence of functional 5-HT4 receptors in human and its involvement in neonatal lupus erythematosus (NLE) have prompted us to study the receptor expression and role during embryogenesis. Earlier we managed to...

    Authors: Rehab Kamel, Simone Garcia, Frank Lezoualc'h, Rodolphe Fischmeister, Sylviane Muller, Johan Hoebeke and Pierre Eftekhari
    Citation: BMC Developmental Biology 2007 7:34
  23. Considerably less attention has been given to understanding the cellular components of gliogenesis in the telencephalon when compared to neuronogenesis, despite the necessity of normal glial cell formation for...

    Authors: Frederick G Strathmann, Xi Wang and Margot Mayer-Pröschel
    Citation: BMC Developmental Biology 2007 7:33
  24. Nogo-A, a myelin-associated protein, inhibits neurite outgrowth and abates regeneration in the adult vertebrate central nervous system (CNS) and may play a role in maintaining neural pathways once established....

    Authors: Shelley A Caltharp, Charmaine U Pira, Noboru Mishima, Erik N Youngdale, David S McNeill, Boleslaw H Liwnicz and Kerby C Oberg
    Citation: BMC Developmental Biology 2007 7:32
  25. Stromal derived factor (SDF-1), an alpha chemokine, is a widely known chemoattractant in the immune system. A growing body of evidence now suggests multiple regulatory roles for SDF-1 in the developing nervous...

    Authors: James Pritchett, Clare Wright, Leo Zeef and Bagirathy Nadarajah
    Citation: BMC Developmental Biology 2007 7:31
  26. The retinoblastoma tumor suppressor (Rb) acts in a conserved pathway that is deregulated in most human cancers. Inactivation of the single Rb-related gene in Caenorhabditis elegans, lin-35, has only limited effec...

    Authors: Julian Ceron, Jean-François Rual, Abha Chandra, Denis Dupuy, Marc Vidal and Sander van den Heuvel
    Citation: BMC Developmental Biology 2007 7:30
  27. Perlecan is a proteoglycan expressed in the basal lamina of the neuroepithelium during development. Perlecan absence does not impair basal lamina assembly, although in the 55% of the mutants early disruptions ...

    Authors: Amparo Girós, Javier Morante, Cristina Gil-Sanz, Alfonso Fairén and Mercedes Costell
    Citation: BMC Developmental Biology 2007 7:29
  28. Targeted disruption of the murine 3β-hydroxysterol-Δ7-reductase gene (Dhcr7), an animal model of Smith-Lemli-Opitz syndrome, leads to loss of cholesterol synthesis and neonatal death that can be partially rescued...

    Authors: Hongwei Yu, Man Li, G Stephen Tint, Jianliang Chen, Guorong Xu and Shailendra B Patel
    Citation: BMC Developmental Biology 2007 7:27
  29. In order to further distinguish unique from general functions of connexin43, we have generated mice in which the coding region of connexin43 was replaced by that of connexin26.

    Authors: Elke Winterhager, Nicole Pielensticker, Jennifer Freyer, Alexander Ghanem, Jan W Schrickel, Jung-Sun Kim, Rüdiger Behr, Ruth Grümmer, Karen Maass, Stephanie Urschel, Thorsten Lewalter, Klaus Tiemann, Manuela Simoni and Klaus Willecke
    Citation: BMC Developmental Biology 2007 7:26
  30. The mouse anterior visceral endoderm (AVE) and the chick hypoblast are thought to have homologous roles in the early stages of neural induction and primitive streak formation. In mouse, many regulatory element...

    Authors: Amanda Albazerchi, Olivier Cinquin and Claudio D Stern
    Citation: BMC Developmental Biology 2007 7:25
  31. The capability of human mesenchymal stem cells (hMSC) derived of adult bone marrow to undergo in vitro hepatic differentiation was investigated.

    Authors: Sarah Snykers, Tamara Vanhaecke, Ann De Becker, Peggy Papeleu, Mathieu Vinken, Ivan Van Riet and Vera Rogiers
    Citation: BMC Developmental Biology 2007 7:24
  32. The formation of the posterior lateral line of teleosts depends on the migration of a primordium that originates near the otic vesicle and moves to the tip of the tail. Groups of cells at the trailing edge of ...

    Authors: Christine Dambly-Chaudière, Nicolas Cubedo and Alain Ghysen
    Citation: BMC Developmental Biology 2007 7:23
  33. Ferlins are membrane proteins with multiple C2 domains and proposed functions in Ca2+ mediated membrane-membrane interactions in animals. Caenorhabditis elegans has two ferlin genes, one of which is required for ...

    Authors: Michelle K Smith and Barbara T Wakimoto
    Citation: BMC Developmental Biology 2007 7:21
  34. In C. elegans and other nematode species, body size is determined by the composition of the extracellular cuticle as well as by the nuclear DNA content of the underlying hypodermis. Mutants that are defective in ...

    Authors: Gwen Soete, Marco C Betist and Hendrik C Korswagen
    Citation: BMC Developmental Biology 2007 7:20
  35. RNA interference coupled with videorecording of C. elegans embryos is a powerful method for identifying genes involved in cell division processes. Here we present a functional analysis of the gene B0511.9, previo...

    Authors: Yan Dong, Aliona Bogdanova, Bianca Habermann, Wolfgang Zachariae and Julie Ahringer
    Citation: BMC Developmental Biology 2007 7:19
  36. C-type natriuretic peptide (CNP) has recently been identified as an important anabolic regulator of endochondral bone growth, but the molecular mechanisms mediating its effects are not completely understood.

    Authors: Hanga Agoston, Sameena Khan, Claudine G James, J Ryan Gillespie, Rosa Serra, Lee-Anne Stanton and Frank Beier
    Citation: BMC Developmental Biology 2007 7:18
  37. In the cerebellum of newborn S100B-EGFP mice, we had previously noted the presence of a large population of S100B-expressing cells, which we assumed to be immature Bergmann glial cells. In the present study, we h...

    Authors: Sabira Hachem, Anne-Sophie Laurenson, Jean-Philippe Hugnot and Catherine Legraverend
    Citation: BMC Developmental Biology 2007 7:17
  38. This study reports the identification of a full-length cDNA sequence for two novel caprine prolactin-related proteins (cPRP1 and cPRP6), and their localization and quantitative expression in the placenta. Capr...

    Authors: Koichi Ushizawa, Toru Takahashi, Misa Hosoe, Keiichiro Kizaki, Yasuyuki Abe, Hiroshi Sasada, Eimei Sato and Kazuyoshi Hashizume
    Citation: BMC Developmental Biology 2007 7:16
  39. The receptor for advanced glycation end products (mRAGE) is associated with pathology in most tissues, while its soluble form (sRAGE) acts as a decoy receptor. The adult lung is unique in that it expresses hig...

    Authors: Pierre-Paul Lizotte, Lana E Hanford, Jan J Enghild, Eva Nozik-Grayck, Brenda-Louise Giles and Tim D Oury
    Citation: BMC Developmental Biology 2007 7:15
  40. Real-time PCR is an efficient tool to measure transcripts and provide valuable quantitative information on gene expression of preimplantation stage embryos. Finding valid reference genes for normalization is e...

    Authors: Solomon Mamo, Arpad Baji Gal, Szilard Bodo and Andras Dinnyes
    Citation: BMC Developmental Biology 2007 7:14
  41. Most differentiating cells are arrested in G1-phase of the cell cycle and this proliferative quiescence appears important to allow differentiation programmes to be executed. An example occurs in the Drosophila ey...

    Authors: Luis M Escudero and Matthew Freeman
    Citation: BMC Developmental Biology 2007 7:13
  42. The mechanisms responsible for the maintenance of pluripotency in human embryonic stem cells, and those that drive their commitment into particular differentiation lineages, are poorly understood. In fact, eve...

    Authors: Andrew L Laslett, Sean Grimmond, Brooke Gardiner, Lincon Stamp, Adelia Lin, Susan M Hawes, Sam Wormald, David Nikolic-Paterson, David Haylock and Martin F Pera
    Citation: BMC Developmental Biology 2007 7:12