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  1. Term Amniotic membrane (AM) is a very attractive source of Mesenchymal Stem Cells (MSCs) due to the fact that this fetal tissue is usually discarded without ethical conflicts, leading to high efficiency in MSC...

    Authors: Francesco Alviano, Valentina Fossati, Cosetta Marchionni, Mario Arpinati, Laura Bonsi, Michele Franchina, Giacomo Lanzoni, Silvia Cantoni, Claudia Cavallini, Francesca Bianchi, Pier Luigi Tazzari, Gianandrea Pasquinelli, Laura Foroni, Carlo Ventura, Alberto Grossi and Gian Paolo Bagnara
    Citation: BMC Developmental Biology 2007 7:11
  2. Nerve growth factor and neurotrophin-3 are involved in the development of sympathetic neurons; however, whether brain derived neurotrophic factor also plays a role is not known. The purpose of this study was t...

    Authors: Jennifer A Straub, Giselle L Saulnier Sholler and Rae Nishi
    Citation: BMC Developmental Biology 2007 7:10
  3. Interfollicular skin develops normally only when the activity of the progenitor cells in the basal layer is counterbalanced by the exit of cells into the suprabasal layers, where they differentiate and cornify...

    Authors: Marni A Slavik, B Lynn Allen-Hoffmann, Bob Y Liu and Caroline M Alexander
    Citation: BMC Developmental Biology 2007 7:9
  4. To date, the earliest stage at which the orientation of the anterior-posterior axis in the mouse embryo is distinguishable by asymmetric gene expression is shortly after E5.5. At E5.5, prospective anterior mar...

    Authors: Stephen Frankenberg, Lee Smith, Andy Greenfield and Magdalena Zernicka-Goetz
    Citation: BMC Developmental Biology 2007 7:8
  5. Formation of branching tubes is a fundamental step in the development of glandular organs. To identify extracellular cues that orchestrate epithelial tubulogenesis, we employed an in vitro assay in which EpH4-...

    Authors: Roberto Montesano, Fabio Carrozzino and Priscilla Soulié
    Citation: BMC Developmental Biology 2007 7:7
  6. Self-renewal of the epithelium of the small intestine is a highly regulated process involving cell proliferation and differentiation of stem cells or progenitor cells located at the bottom of the crypt, ending...

    Authors: Hai-Su Yang and Philip W Hinds
    Citation: BMC Developmental Biology 2007 7:6
  7. β-catenin is an essential mediator of canonical Wnt signaling and a central component of the cadherin-catenin epithelial adhesion complex. Dysregulation of β-catenin expression has been described in pancreatic...

    Authors: James M Wells, Farzad Esni, Gregory P Boivin, Bruce J Aronow, William Stuart, Chelsea Combs, Angela Sklenka, Steven D Leach and Andrew M Lowy
    Citation: BMC Developmental Biology 2007 7:4
  8. Primordial germ cells (PGCs) give rise to gametes that are responsible for the development of a new organism in the next generation. Two modes of germ line specification have been described: the inheritance of...

    Authors: Amaury Herpin, Stefan Rohr, Dietmar Riedel, Nils Kluever, Erez Raz and Manfred Schartl
    Citation: BMC Developmental Biology 2007 7:3
  9. Mechanisms that confer an ability to respond positively to environmental osmolarity are fundamental to ensuring embryo survival during the preimplantation period. Activation of p38 mitogen-activated protein ki...

    Authors: Barry Fong, Patricia H Watson and Andrew J Watson
    Citation: BMC Developmental Biology 2007 7:2
  10. Myf5 is one member of the basic helix-loop-helix family of transcription factors, and it functions as a myogenic factor that is important for the specification and differentiation of muscle cells. The expressi...

    Authors: Yau-Hung Chen, Yun-Hsin Wang, Min-Yen Chang, Cheng-Yung Lin, Chih-Wei Weng, Monte Westerfield and Huai-Jen Tsai
    Citation: BMC Developmental Biology 2007 7:1
  11. The molecular mechanisms governing the formation of the embryonic vascular system remain poorly understood. Here, we show that Disabled-2 (Dab2), a cytosolic adaptor protein, has a pivotal role in the blood ve...

    Authors: Seong-Moon Cheong, Sun-Cheol Choi and Jin-Kwan Han
    Citation: BMC Developmental Biology 2006 6:63
  12. Polarised gene expression is thought to lead to the graded distribution of signaling molecules providing a patterning mechanism across the embryonic eye. Bone morphogenetic protein 4 (Bmp4) is expressed in the do...

    Authors: Hourinaz Behesti, James KL Holt and Jane C Sowden
    Citation: BMC Developmental Biology 2006 6:62
  13. We have recently reported the expression of murine Implantation Serine Proteinase genes in pre-implantation embryos (ISP1) and uterus (ISP1 and ISP2). These proteinases belong to the S1 proteinase family and a...

    Authors: Navneet Sharma, Shiying Liu, Lin Tang, Jackie Irwin, Guoliang Meng and Derrick E Rancourt
    Citation: BMC Developmental Biology 2006 6:61
  14. Cellularization of the Drosophila embryo is an unusually synchronous form of cytokinesis in which polarized membrane extension proceeds in part through incorporation of new membrane via fusion of apically-translo...

    Authors: Mary LaLonde, Hilde Janssens, Suyong Yun, Juan Crosby, Olga Redina, Virginie Olive, Yelena M Altshuller, Seok-Yong Choi, Guangwei Du, J Peter Gergen and Michael A Frohman
    Citation: BMC Developmental Biology 2006 6:60
  15. The functions of three zona glycoproteins, ZP1, ZP2 and ZP3 during the sperm-zona pellucida (ZP) interaction are now well established in mice. The expression of an additional zona glycoprotein, ZPB/4, in human...

    Authors: Catherine Patrat, Jana Auer, Patricia Fauque, Roger L Leandri, Pierre Jouannet and Catherine Serres
    Citation: BMC Developmental Biology 2006 6:59
  16. The development and regression of corpus luteum (CL) is characterized by an intense angiogenesis and angioregression accompanied by luteal tissue and extracellular matrix (ECM) remodelling. Vascular Endothelia...

    Authors: Luciana Andrea Ribeiro, Maria Elena Turba, Augusta Zannoni, Maria Laura Bacci and Monica Forni
    Citation: BMC Developmental Biology 2006 6:58
  17. Circadian clocks have been implicated in the regulation of pre-adult development of fruit flies Drosophila melanogaster. It is believed that faster clocks speed up development and slower clocks slow it down. We e...

    Authors: Shailesh Kumar, Koustubh M Vaze, Dhanya Kumar and Vijay K Sharma
    Citation: BMC Developmental Biology 2006 6:57
  18. The human NECDIN gene is involved in a neurodevelopmental disorder, Prader-Willi syndrome (PWS). Previously we reported a mouse Necdin knock-out model with similar defects to PWS patients. Despite the putative ro...

    Authors: David Andrieu, Hamid Meziane, Fabienne Marly, Corinne Angelats, Pierre-Alain Fernandez and Françoise Muscatelli
    Citation: BMC Developmental Biology 2006 6:56
  19. Precise temporal and spatial regulation of transgene expression is a critical tool to investigate gene function in developing organisms. The most commonly used technique to achieve tight control of transgene e...

    Authors: Diane M Ramos, Firdous Kamal, Ernst A Wimmer, Alexander N Cartwright and Antónia Monteiro
    Citation: BMC Developmental Biology 2006 6:55
  20. Calreticulin is a Ca2+ binding chaperone of the endoplasmic reticulum which influences gene expression and cell adhesion. The levels of both vinculin and N-cadherin are induced by calreticulin expression, which p...

    Authors: Mira D Lozyk, Sylvia Papp, Xiaochu Zhang, Kimitoshi Nakamura, Marek Michalak and Michal Opas
    Citation: BMC Developmental Biology 2006 6:54
  21. The regulation of proneural gene expression is an important aspect of neurogenesis. In the study of the Drosophila proneural genes, scute and atonal, several themes have emerged that contribute to our understandi...

    Authors: Eimear E Holohan, Petra I zur Lage and Andrew P Jarman
    Citation: BMC Developmental Biology 2006 6:53
  22. Butterfly and moth eyespots can share a similar appearance, involving multiple concentric rings of colored scales, but usually occuring in non-homologous positions on the wing. Within the butterflies, on the o...

    Authors: Antónia Monteiro, Gary Glaser, Steven Stockslager, Nelleke Glansdorp and Diane Ramos
    Citation: BMC Developmental Biology 2006 6:52
  23. Congenital cardiovascular diseases are the most common form of birth defects in humans. A substantial portion of these defects has been associated with inappropriate induction, migration, differentiation and p...

    Authors: Jikui Wang, Andre Nagy, Jonas Larsson, Marek Dudas, Henry M Sucov and Vesa Kaartinen
    Citation: BMC Developmental Biology 2006 6:51
  24. The homeodomain transcription factor Orthopedia (Otp) is essential in restricting the fate of multiple classes of secreting neurons in the neuroendocrine hypothalamus of vertebrates. However, there is little i...

    Authors: Luca Del Giacco, Paolo Sordino, Anna Pistocchi, Nikos Andreakis, Raffaella Tarallo, Barbara Di Benedetto and Franco Cotelli
    Citation: BMC Developmental Biology 2006 6:50
  25. Metamorphosis is a complex, highly conserved and strictly regulated development process that involves the programmed cell death of obsolete larval organs. Here we show a novel functional role for the aspartic ...

    Authors: Zhong Zheng Gui, Kwang Sik Lee, Bo Yeon Kim, Yong Soo Choi, Ya Dong Wei, Young Moo Choo, Pil Don Kang, Hyung Joo Yoon, Iksoo Kim, Yeon Ho Je, Sook Jae Seo, Sang Mong Lee, Xijie Guo, Hung Dae Sohn and Byung Rae Jin
    Citation: BMC Developmental Biology 2006 6:49
  26. Between embryonic day 12 and postnatal day 21, six major neuronal and one glia cell type are generated from multipotential progenitors in a characteristic sequence during mouse retina development. We investiga...

    Authors: Samuel Shao-Min Zhang, Xuming Xu, Mu-Gen Liu, Hongyu Zhao, Marcelo Bento Soares, Colin J Barnstable and Xin-Yuan Fu
    Citation: BMC Developmental Biology 2006 6:48
  27. The ovulatory surge of gonadotropins triggers oocyte maturation and rupture of the ovarian follicle. The resumption of nuclear maturation in the oocyte from the prophase stage is characterized by germinal vesi...

    Authors: Maxime Sasseville, Nancy Côté, Christine Guillemette and François J Richard
    Citation: BMC Developmental Biology 2006 6:47
  28. Knowledge of the consequences of heterozygous mutations of developmentally important genes is important for understanding human genetic disorders. The Gli3 gene encodes a zinc finger transcription factor and homo...

    Authors: Paulette A Zaki, J Martin Collinson, Junko Toraiwa, T Ian Simpson, David J Price and Jane C Quinn
    Citation: BMC Developmental Biology 2006 6:46
  29. In the nematode, Caenorhabditis elegans, a conserved insulin-like signaling pathway controls larval development, stress resistance and adult lifespan. AGE-1, a homolog of the p110 catalytic subunit of phosphoinos...

    Authors: Minaxi S Gami, Wendy B Iser, Keaton B Hanselman and Catherine A Wolkow
    Citation: BMC Developmental Biology 2006 6:45
  30. WNT4 is a key regulator of gonadal differentiation in humans and mice, playing a pivotal role in early embryogenesis. Using a marsupial, the tammar wallaby, in which most gonadal differentiation occurs after b...

    Authors: Hongshi Yu, Andrew J Pask, Geoffrey Shaw and Marilyn B Renfree
    Citation: BMC Developmental Biology 2006 6:44
  31. In Xenopus the bone morphogenetic protein growth and differentiation factor 6 (GDF6) is expressed at the edge of the neural plate, and within the anterior neural plate including the eye fields. Here we address th...

    Authors: Meredith L Hanel and Carmel Hensey
    Citation: BMC Developmental Biology 2006 6:43
  32. Human studies suggest, and mouse models clearly demonstrate, that cytomegalovirus (CMV) is dysmorphic to early organ and tissue development. CMV has a particular tropism for embryonic salivary gland and other ...

    Authors: Michael Melnick, Edward S Mocarski, George Abichaker, Jing Huang and Tina Jaskoll
    Citation: BMC Developmental Biology 2006 6:42
  33. Somatic cell nuclear transfer (SCNT) provides an appealing alternative for the preservation of genetic material in non-domestic and endangered species. An important prerequisite for successful SCNT is the avai...

    Authors: Gabriela F Mastromonaco, Steve D Perrault, Dean H Betts and W Allan King
    Citation: BMC Developmental Biology 2006 6:41
  34. Individual differences between human embryonic stem cell (hESC) lines are poorly understood. Here, we describe the derivation of five hESC lines (called FES 21, 22, 29, 30 and 61) from frozen-thawed human embr...

    Authors: Milla Mikkola, Cia Olsson, Jaan Palgi, Jarkko Ustinov, Tiina Palomaki, Nina Horelli-Kuitunen, Sakari Knuutila, Karolina Lundin, Timo Otonkoski and Timo Tuuri
    Citation: BMC Developmental Biology 2006 6:40
  35. The Rho-kinases (ROCKs) are major effector targets of the activated Rho GTPase that have been implicated in many of the Rho-mediated effects on cell shape and movement via their ability to affect acto-myosin c...

    Authors: Valerie Verdier, Guang-Chao-Chen and Jeffrey Settleman
    Citation: BMC Developmental Biology 2006 6:38
  36. Large conductance calcium- and voltage activated potassium (BK) channels are important determinants of neuronal excitability through effects on action potential duration, frequency and synaptic efficacy. The p...

    Authors: Stephen H-F MacDonald, Peter Ruth, Hans-Guenther Knaus and Michael J Shipston
    Citation: BMC Developmental Biology 2006 6:37
  37. The persistence in adult teleost fish of retinal stem cells that exhibit all of the features of true 'adult stem cells' – self-renewal, multipotency, and the capacity to respond to injury by mitotic activation...

    Authors: Pamela A Raymond, Linda K Barthel, Rebecca L Bernardos and John J Perkowski
    Citation: BMC Developmental Biology 2006 6:36
  38. Development of lung alveolar sacs of normal structure and size at late gestation is necessary for the gas exchange process that sustains respiration at birth. Mice lacking the lung differentiation gene T1α [T1...

    Authors: Guetchyn Millien, Avrum Spira, Anne Hinds, Junling Wang, Mary C Williams and Maria I Ramirez
    Citation: BMC Developmental Biology 2006 6:35
  39. We previously identified a set of genes called ECATs (ES cell-associated transcripts) that are expressed at high levels in mouse ES cells. Here, we examine the expression and DNA methylation of ECATs in somati...

    Authors: Masanori Imamura, Kyoko Miura, Kumiko Iwabuchi, Tomoko Ichisaka, Masato Nakagawa, Jiyoung Lee, Mito Kanatsu-Shinohara, Takashi Shinohara and Shinya Yamanaka
    Citation: BMC Developmental Biology 2006 6:34
  40. Development of the enteric nervous system (ENS) requires interactions between migrating neural crest cells and the nascent gastrointestinal tract that are dependent upon genes expressed by both cell compartmen...

    Authors: Michael D Bates, Dana T Dunagan, Lynn C Welch, Ajay Kaul and Richard P Harvey
    Citation: BMC Developmental Biology 2006 6:33
  41. Plexins are a family of transmembrane proteins that were shown to act as receptors for Semaphorins either alone or in a complex together with Neuropilins. Based on structural criteria Plexins were subdivided i...

    Authors: Olivier Mauti, Rejina Sadhu, Joelle Gemayel, Matthias Gesemann and Esther T Stoeckli
    Citation: BMC Developmental Biology 2006 6:32
  42. cAMP-induced Ca2+-influx in Dictyostelium is controlled by at least two non-mitochondrial Ca2+-stores: acidic stores and the endoplasmic reticulum (ER). The acidic stores may comprise the contractile vacuole netw...

    Authors: Dieter Malchow, Daniel F Lusche, Christina Schlatterer, Arturo De Lozanne and Annette Müller-Taubenberger
    Citation: BMC Developmental Biology 2006 6:31
  43. Cubilin is a peripheral membrane protein that interacts with the integral membrane proteins megalin and amnionless to mediate ligand endocytosis by absorptive epithelia such as the extraembryonic visceral endo...

    Authors: Brian T Smith, Jason C Mussell, Paul A Fleming, Jeremy L Barth, Demetri D Spyropoulos, Marion A Cooley, Christopher J Drake and W Scott Argraves
    Citation: BMC Developmental Biology 2006 6:30
  44. In stalk-eyed flies (Diopsidae) the eyes and antennae are laterally displaced at the ends of elongated eyestalks. Eyespan and the degree of sexual dimorphism in eyespan vary considerably between species and se...

    Authors: Martin Carr, Samuel Cotton, David W Rogers, Andrew Pomiankowski, Hazel Smith and Kevin Fowler
    Citation: BMC Developmental Biology 2006 6:29
  45. Craniofacial birth defects result from defects in cranial neural crest (NC) patterning and morphogenesis. The vertebrate craniofacial skeleton is derived from cranial NC cells and the patterning of these cells...

    Authors: Robert M Nissen, Adam Amsterdam and Nancy Hopkins
    Citation: BMC Developmental Biology 2006 6:28
  46. Studies of the Xenopus organizer have laid the foundation for our understanding of the conserved signaling pathways that pattern vertebrate embryos during gastrulation. The two primary activities of the organizer...

    Authors: Andrew L Hufton, Arunachalam Vinayagam, Sándor Suhai and Julie C Baker
    Citation: BMC Developmental Biology 2006 6:27
  47. Mater (Maternal Antigen that Embryos Require), also known as Nalp5 (NACHT, leucine rich repeat and PYD containing 5), is an oocyte-specific maternal effect gene required for early embryonic development beyond the...

    Authors: Sophie Pennetier, Christine Perreau, Svetlana Uzbekova, Aurore Thélie, Bernadette Delaleu, Pascal Mermillod and Rozenn Dalbiès-Tran
    Citation: BMC Developmental Biology 2006 6:26
  48. Pax6 is a transcription factor essential for normal development of the eyes and nervous system. It has two major isoforms, Pax6 and Pax6(5a), and the ratios between their expression levels vary within narrow l...

    Authors: Jeni Pinson, T Ian Simpson, John O Mason and David J Price
    Citation: BMC Developmental Biology 2006 6:25