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  2. Mammalian early development comprises the proliferation, differentiation, and self-assembly of the embryonic cells. The classic experiment undertaken by Townes and Holtfreter demonstrated the ability of dissoc...

    Authors: Jeffrey D. Tse, Robert Moore, Yue Meng, Wensi Tao, Elizabeth R. Smith and Xiang-Xi Xu

    Citation: BMC Developmental Biology 2021 21:2

    Content type: Research article

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  3. Phosphate is the major ingredient of bone tissue, and is also an important component of commercial bone substitute materials, bone scaffolds, and implant surface coatings. With the dissolution of the bone subs...

    Authors: Hengzhang Lin, Yong Zhou, Qun Lei, Dong Lin, Jiang Chen and Chuhuo Wu

    Citation: BMC Developmental Biology 2021 21:1

    Content type: Research article

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  4. Joubert syndrome and related disorders (JSRD) and Jeune syndrome are multisystem ciliopathy disorders with overlapping phenotypes. There are a growing number of genetic causes for these rare syndromes, includi...

    Authors: L. Powell, M. Barroso-Gil, G. J. Clowry, L. A. Devlin, E. Molinari, S. A. Ramsbottom, C. G. Miles and J. A. Sayer

    Citation: BMC Developmental Biology 2020 20:26

    Content type: Research article

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  5. Genotype independent transformation and whole plant regeneration through somatic embryogenesis relies heavily on the intrinsic ability of a genotype to regenerate. The critical genetic architecture of non-embr...

    Authors: Li Wen, Wei Li, Stephen Parris, Matthew West, John Lawson, Michael Smathers, Zhigang Li, Don Jones, Shuangxia Jin and Christopher A. Saski

    Citation: BMC Developmental Biology 2020 20:25

    Content type: Research article

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  7. Nitric oxide (NO) is presumed to be a regulator of metamorphosis in many invertebrate species, and although NO pathways have been comparatively well-investigated in gastropods, annelids and crustaceans, there ...

    Authors: Susanne Vogeler, Stefano Carboni, Xiaoxu Li, Nancy Nevejan, Sean J. Monaghan, Jacqueline H. Ireland and Alyssa Joyce

    Citation: BMC Developmental Biology 2020 20:23

    Content type: Research article

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  8. Tissue regeneration mediated by mesenchymal stem cells (MSCs) is deemed a desirable way to repair teeth and craniomaxillofacial tissue defects. Nevertheless, the molecular mechanisms about cell proliferation a...

    Authors: Xiaomin Su, Haoqing Yang, Ruitang Shi, Chen Zhang, Huina Liu, Zhipeng Fan and Jianpeng Zhang

    Citation: BMC Developmental Biology 2020 20:22

    Content type: Research article

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  9. Organismal fitness can be determined at early life-stages, but phenotypic variation at early life-stages is rarely considered in studies on evolutionary diversification. The trophic apparatus has been shown to...

    Authors: Samantha V. Beck, Katja Räsänen, Camille A. Leblanc, Skúli Skúlason, Zophonías O. Jónsson and Bjarni K. Kristjánsson

    Citation: BMC Developmental Biology 2020 20:21

    Content type: Research article

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  10. Monocyte chemoattractant protein-1(MCP-1) is a chemokine secreted by Leydig cells and peritubular myoid cells in the rat testis. Its role in regulating the development of Leydig cells via autocrine and paracri...

    Authors: Xiangcheng Zhan, Jingwei Zhang, Saiyang Li, Xiaolu Zhang, Linchao Li, Tiantian Song, Qunlong Liu, Jun Lu, Yunfei Xu and Ren-Shan Ge

    Citation: BMC Developmental Biology 2020 20:20

    Content type: Research article

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  11. Masculinizer (Masc) plays a pivotal role in male sex determination in the silkworm, Bombyx mori. Masc is required for male-specific splicing of B. mori doublesex (Bmdsx) transcripts. The male isoform of Bmdsx (Bm...

    Authors: Tomohisa Yuzawa, Misato Matsuoka, Megumi Sumitani, Fugaku Aoki, Hideki Sezutsu and Masataka G. Suzuki

    Citation: BMC Developmental Biology 2020 20:19

    Content type: Research article

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  12. The morphogenesis of the shell field is an essential step of molluscan shell formation, which exhibits both conserved features and interlineage variations. As one major gastropod lineage, the patellogastropods...

    Authors: Weihong Yang, Pin Huan and Baozhong Liu

    Citation: BMC Developmental Biology 2020 20:18

    Content type: Research article

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  13. p120 catenin (p120ctn) is an important component in the cadherin-catenin cell adhesion complex because it stabilizes cadherin-mediated intercellular junctions. Outside these junctions, p120ctn is actively invo...

    Authors: Tim Pieters, Ellen Sanders, Huiyu Tian, Jolanda van Hengel and Frans van Roy

    Citation: BMC Developmental Biology 2020 20:17

    Content type: Research article

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  15. Changes in transcellular bioelectrical patterns are known to play important roles during developmental and regenerative processes. The Drosophila follicular epithelium has proven to be an appropriate model system...

    Authors: Susanne Katharina Schotthöfer and Johannes Bohrmann

    Citation: BMC Developmental Biology 2020 20:15

    Content type: Research article

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  16. Hazels (Corylus spp.) are economically important nut-producing species in which ovule development determines seed plumpness, one of the key parameters reflecting nut quality. microRNAs (miRNAs) play important rol...

    Authors: Jianfeng Liu, Qizheng Luo, Xingzheng Zhang, Qiang Zhang and Yunqing Cheng

    Citation: BMC Developmental Biology 2020 20:13

    Content type: Research article

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  17. Archipelago (Ago) is a Drosophila homolog of mammalian F-box and WD repeat domain-containing 7 (FBW7, also known as FBXW7). In previous studies, FBW7 has been addressed as a tumor suppressor mediating ubiquitin-d...

    Authors: Sujin Nam and Kyung-Ok Cho

    Citation: BMC Developmental Biology 2020 20:14

    Content type: Research article

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  18. Scaffold proteins support a variety of key processes during animal development. Mutant mouse for the MAGUK protein Discs large 5 (Dlg5) presents a general growth impairment and moderate morphogenetic defects.

    Authors: Parvathy Venugopal, Hugo Veyssière, Jean-Louis Couderc, Graziella Richard, Caroline Vachias and Vincent Mirouse

    Citation: BMC Developmental Biology 2020 20:10

    Content type: Research article

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  19. Mammalian early embryo development requires a well-orchestrated interplay of cell signaling pathways. Notch is a major regulatory pathway involved in cell-fate determination in embryonic and adult scenarios. H...

    Authors: Mariana R. Batista, Patrícia Diniz, Ana Torres, Daniel Murta, Luís Lopes-da-Costa and Elisabete Silva

    Citation: BMC Developmental Biology 2020 20:9

    Content type: Research article

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  20. During mammalian cerebral cortex development, different types of projection neurons are produced in a precise temporal order and in stereotypical numbers. The mechanisms regulating timely generation of neocort...

    Authors: Anthony Kischel, Christophe Audouard, Mohamad-Ali Fawal and Alice Davy

    Citation: BMC Developmental Biology 2020 20:12

    Content type: Research article

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  21. The tissue regeneration process requires high oxygen and energy levels. Cytoglobin (Cygb) is a member of the globin family, which has the ability to bind oxygen, plays a role in dealing with oxidative stress, ...

    Authors: Titta Novianti, Vetnizah Juniantito, Ahmad Aulia Jusuf, Evy Ayu Arida, Mohamad Sadikin and Sri Widia A. Jusman

    Citation: BMC Developmental Biology 2020 20:11

    Content type: Research article

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  22. Hair follicles are an appendage of the vertebrate epithelium in the skin that arise from the embryonic ectoderm and regenerate cyclically during adulthood. Dermal papilla cells (DPCs) are the key dermal compon...

    Authors: Gongyan Liu, Shu Li, Hongli Liu, Yanli Zhu, Liya Bai, Haitao Sun, Shuxia Gao, Wenxue Jiang and Fuchang Li

    Citation: BMC Developmental Biology 2020 20:8

    Content type: Research article

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  23. Octopus vulgaris has been an iconic cephalopod species for neurobiology research as well as for cephalopod aquaculture. It is one of the most intelligent and well-studied invertebrates, possessing both long- and ...

    Authors: Astrid Deryckere, Ruth Styfhals, Erica A. G. Vidal, Eduardo Almansa and Eve Seuntjens

    Citation: BMC Developmental Biology 2020 20:7

    Content type: Research article

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  24. Eyespot color pattern formation on butterfly wings is sensitive to physical damage and physical distortion as well as physical contact with materials on the surface of wing epithelial tissue at the pupal stage...

    Authors: Joji M. Otaki

    Citation: BMC Developmental Biology 2020 20:6

    Content type: Research article

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  25. Bioelectrical signals are known to be involved in the generation of cell and tissue polarity as well as in cytoskeletal dynamics. The epithelium of Drosophila ovarian follicles is a suitable model system for stud...

    Authors: Susanne Katharina Schotthöfer and Johannes Bohrmann

    Citation: BMC Developmental Biology 2020 20:5

    Content type: Research article

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  26. Pancreatic organoid systems have recently been described for the in vitro culture of pancreatic ductal cells from mouse and human. Mouse pancreatic organoids exhibit unlimited expansion potential, while previo...

    Authors: Nikitas Georgakopoulos, Nicole Prior, Brigitte Angres, Gianmarco Mastrogiovanni, Alex Cagan, Daisy Harrison, Christopher J. Hindley, Robert Arnes-Benito, Siong-Seng Liau, Abbie Curd, Natasha Ivory, Benjamin D. Simons, Inigo Martincorena, Helmut Wurst, Kourosh Saeb-Parsy and Meritxell Huch

    Citation: BMC Developmental Biology 2020 20:4

    Content type: Methodology article

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  29. In normal mammalian development a high percentage of implantations is lost by spontaneous resorption. This is a major problem in assisted reproduction and blastocyst transfer. Which embryo will be resorbed is ...

    Authors: Barbara Drews, Luis Flores Landaverde, Anja Kühl and Ulrich Drews

    Citation: BMC Developmental Biology 2020 20:1

    Content type: Research article

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  30. Rab proteins are GTPases responsible for intracellular vesicular trafficking regulation. Rab11 proteins, members of the Rab GTPase family, are known to regulate vesicular recycling during embryonic development...

    Authors: Haijun Zhang, Yu Gao, Peipei Qian, Zhangji Dong, Wenjin Hao, Dong Liu and Xuchu Duan

    Citation: BMC Developmental Biology 2019 19:25

    Content type: Research article

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  31. Tardigrades are microscopic organisms, famous for their tolerance against extreme environments. The establishment of rearing systems of multiple species has allowed for comparison of tardigrade physiology, in ...

    Authors: Yuki Yoshida, Kenta Sugiura, Masaru Tomita, Midori Matsumoto and Kazuharu Arakawa

    Citation: BMC Developmental Biology 2019 19:24

    Content type: Research article

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  32. Epigenetic regulation of oocyte-specific maternal factors is essential for oocyte and early embryonic development. KPNA7 is an oocyte-specific maternal factor, which controls transportation of nuclear proteins...

    Authors: Lei Wang, Jacqelyn M. Hand, Liyuan Fu, George W. Smith and Jianbo Yao

    Citation: BMC Developmental Biology 2019 19:23

    Content type: Research article

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  33. During Drosophila oogenesis, the follicular epithelium differentiates into several morphologically distinct follicle-cell populations. Characteristic bioelectrical properties make this tissue a suitable model sys...

    Authors: Isabel Weiß and Johannes Bohrmann

    Citation: BMC Developmental Biology 2019 19:22

    Content type: Research article

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  34. Animals with polyploid, hybrid nuclei offer a challenge for models of gene expression and regulation during embryogenesis. To understand how such organisms proceed through development, we examined the timing a...

    Authors: Noah D. Charney, Jacob E. Kubel, Craig T. Woodard, Blanca I. Carbajal-González, Samantha Avis, Julia A. Blyth, Charles S. Eiseman, John Castorino and John H. Malone

    Citation: BMC Developmental Biology 2019 19:21

    Content type: Research article

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  35. Immature mammalian oocytes are held arrested at prophase I of meiosis by an inhibitory phosphorylation of cyclin-dependent kinase 1 (CDK1). Release from this meiotic arrest and germinal vesicle breakdown is de...

    Authors: Alaa A. Eisa, Santanu De, Ariana Detwiler, Eva Gilker, Alexander C. Ignatious, Srinivasan Vijayaraghavan and Douglas Kline

    Citation: BMC Developmental Biology 2019 19:20

    Content type: Research article

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  36. Mouse NOTCH1 carries a highly conserved O-fucose glycan at Thr466 in epidermal growth factor-like repeat 12 (EGF12) of the extracellular domain. O-Fucose at this site has been shown by X-ray crystallography to...

    Authors: Shweta Varshney, Hua-Xing Wei, Frank Batista, Mohd Nauman, Subha Sundaram, Katherine Siminovitch, Ankit Tanwar and Pamela Stanley

    Citation: BMC Developmental Biology 2019 19:19

    Content type: Research article

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  37. Sonic hedgehog (Shh) is an important signalling protein involved in the induction of early cartilaginous differentiation. Herein, we demonstrate that Shh markedly induces chondrogenesis of rabbit bone marrow s...

    Authors: Liyang Chen, Gejun Liu, Wenjun Li and Xing Wu

    Citation: BMC Developmental Biology 2019 19:18

    Content type: Research article

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  39. The Tet protein family (Tet1, Tet2, and Tet3) regulate DNA methylation through conversion of 5-methylcytosine to 5-hydroxymethylcytosine which can ultimately result in DNA demethylation and play a critical rol...

    Authors: Michael Reimer Jr, Kirthi Pulakanti, Linzheng Shi, Alex Abel, Mingyu Liang, Subramaniam Malarkannan and Sridhar Rao

    Citation: BMC Developmental Biology 2019 19:16

    Content type: Research article

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  40. Prostate androgen-regulated mucin-like protein 1 (PARM1) is a pro-proliferative and anti-apoptotic glycoprotein involved in the endoplasmic reticulum (ER) stress response. A single nucleotide polymorphism in t...

    Authors: Adriana M. Zolini, Verónica M. Negrón-Pérez and Peter J. Hansen

    Citation: BMC Developmental Biology 2019 19:15

    Content type: Research article

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  41. Insulin/insulin-like growth peptide signaling (IIS) down-regulates hemolymph sugar level and facilitates larval growth in the soybean pod borer, Maruca vitrata. The objective of this study is to determine whether...

    Authors: Md. Abdullah Al Baki, Dae-Weon Lee, Jin Kyo Jung and Yonggyun Kim

    Citation: BMC Developmental Biology 2019 19:14

    Content type: Research article

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  42. The segregation of the hypoblast and the emergence of the pluripotent epiblast mark the final stages of blastocyst formation in mammalian embryos. In bovine embryos the formation of the hypoblast has been part...

    Authors: Jesica R. Canizo, Amada E. Ynsaurralde Rivolta, Camila Vazquez Echegaray, Mariana Suvá, Virgilia Alberio, Juan F. Aller, Alejandra S. Guberman, Daniel F. Salamone, Ricardo H. Alberio and Ramiro Alberio

    Citation: BMC Developmental Biology 2019 19:13

    Content type: Research article

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  43. Alterations of bioelectrical properties of cells and tissues are known to function as wide-ranging signals during development, regeneration and wound-healing in several species. The Drosophila follicle-cell epith...

    Authors: Isabel Weiß and Johannes Bohrmann

    Citation: BMC Developmental Biology 2019 19:12

    Content type: Research article

    Published on:

  44. Progressive transformation of the otic placode into the functional inner ear during gestational development in humans leads to the acquisition of hearing perception via the cochlea and balance and spatial orie...

    Authors: Lejo Johnson Chacko, David Wertjanz, Consolato Sergi, Jozsef Dudas, Natalie Fischer, Theresa Eberharter, Romed Hoermann, Rudolf Glueckert, Helga Fritsch, Helge Rask-Andersen, Anneliese Schrott-Fischer and Stephan Handschuh

    Citation: BMC Developmental Biology 2019 19:11

    Content type: Research Article

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  45. Cell differentiation is mediated by synchronized waves of coordinated expression for hundreds to thousands of genes, and must be regulated to produce complex tissues and phenotypes. For many animal species, se...

    Authors: Damien B. Wilburn and Richard C. Feldhoff

    Citation: BMC Developmental Biology 2019 19:10

    Content type: Research article

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  46. Coilia nasus oogenesis/spawning migration is a well-defined synchronous arrangement process. DnaJs are indispensable molecular chaperones for oogenesis process. However, how DnaJs involved the anadromous spawning...

    Authors: Xiao-ting Feng, Xue-jun Yang, Jian-jian Ruan, Ya-qi Wang, Yan-feng Zhou, Dong-po Xu and Di-an Fang

    Citation: BMC Developmental Biology 2019 19:9

    Content type: Research article

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  47. The interstitium of the mouse testis contains Leydig cells and a small number of steroidogenic cells with adrenal characteristics which may be derived from the fetal adrenal during development or may be a norm...

    Authors: Peter J. O’Shaughnessy, Rod T. Mitchell, Ana Monteiro, Laura O’Hara, Lyndsey Cruickshanks, Hedi Claahsen-van der Grinten, Pamela Brown, Margaret Abel and Lee B. Smith

    Citation: BMC Developmental Biology 2019 19:8

    Content type: Research article

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  48. NK genes are a group of homeobox transcription factors that are involved in various molecular pathways across bilaterians. They are typically divided into two subgroups, the NK cluster (NKC) and NK-linked gene...

    Authors: Sandra Treffkorn and Georg Mayer

    Citation: BMC Developmental Biology 2019 19:7

    Content type: Research article

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  49. C-lectin family 14 Member A (Clec14a) is a transmembrane protein specifically expressed in vascular endothelial cells during embryogenesis. Previous in vitro and in vivo studies have provided conflicting data ...

    Authors: Karolina Pociute, Jennifer A. Schumacher and Saulius Sumanas

    Citation: BMC Developmental Biology 2019 19:6

    Content type: Research article

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  50. The embryonic day E10–13 period of mouse heart development is characterized by robust cardiomyocyte proliferation that creates the compact zone of thickened ventricular wall myocardium. This process is initiat...

    Authors: Kai Wang, Hua Shen, Peiheng Gan, Susana Cavallero, S. Ram Kumar, Ching-Ling Lien and Henry M. Sucov

    Citation: BMC Developmental Biology 2019 19:5

    Content type: Research article

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BMC Developmental Biology

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