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  1. Pancreatic organoid systems have recently been described for the in vitro culture of pancreatic ductal cells from mouse and human. Mouse pancreatic organoids exhibit unlimited expansion potential, while previo...

    Authors: Nikitas Georgakopoulos, Nicole Prior, Brigitte Angres, Gianmarco Mastrogiovanni, Alex Cagan, Daisy Harrison, Christopher J. Hindley, Robert Arnes-Benito, Siong-Seng Liau, Abbie Curd, Natasha Ivory, Benjamin D. Simons, Inigo Martincorena, Helmut Wurst, Kourosh Saeb-Parsy and Meritxell Huch

    Citation: BMC Developmental Biology 2020 20:4

    Content type: Methodology article

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  4. In normal mammalian development a high percentage of implantations is lost by spontaneous resorption. This is a major problem in assisted reproduction and blastocyst transfer. Which embryo will be resorbed is ...

    Authors: Barbara Drews, Luis Flores Landaverde, Anja Kühl and Ulrich Drews

    Citation: BMC Developmental Biology 2020 20:1

    Content type: Research article

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  5. Rab proteins are GTPases responsible for intracellular vesicular trafficking regulation. Rab11 proteins, members of the Rab GTPase family, are known to regulate vesicular recycling during embryonic development...

    Authors: Haijun Zhang, Yu Gao, Peipei Qian, Zhangji Dong, Wenjin Hao, Dong Liu and Xuchu Duan

    Citation: BMC Developmental Biology 2019 19:25

    Content type: Research article

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  6. Tardigrades are microscopic organisms, famous for their tolerance against extreme environments. The establishment of rearing systems of multiple species has allowed for comparison of tardigrade physiology, in ...

    Authors: Yuki Yoshida, Kenta Sugiura, Masaru Tomita, Midori Matsumoto and Kazuharu Arakawa

    Citation: BMC Developmental Biology 2019 19:24

    Content type: Research article

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  7. Epigenetic regulation of oocyte-specific maternal factors is essential for oocyte and early embryonic development. KPNA7 is an oocyte-specific maternal factor, which controls transportation of nuclear proteins...

    Authors: Lei Wang, Jacqelyn M. Hand, Liyuan Fu, George W. Smith and Jianbo Yao

    Citation: BMC Developmental Biology 2019 19:23

    Content type: Research article

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  8. During Drosophila oogenesis, the follicular epithelium differentiates into several morphologically distinct follicle-cell populations. Characteristic bioelectrical properties make this tissue a suitable model sys...

    Authors: Isabel Weiß and Johannes Bohrmann

    Citation: BMC Developmental Biology 2019 19:22

    Content type: Research article

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  9. Animals with polyploid, hybrid nuclei offer a challenge for models of gene expression and regulation during embryogenesis. To understand how such organisms proceed through development, we examined the timing a...

    Authors: Noah D. Charney, Jacob E. Kubel, Craig T. Woodard, Blanca I. Carbajal-González, Samantha Avis, Julia A. Blyth, Charles S. Eiseman, John Castorino and John H. Malone

    Citation: BMC Developmental Biology 2019 19:21

    Content type: Research article

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  10. Immature mammalian oocytes are held arrested at prophase I of meiosis by an inhibitory phosphorylation of cyclin-dependent kinase 1 (CDK1). Release from this meiotic arrest and germinal vesicle breakdown is de...

    Authors: Alaa A. Eisa, Santanu De, Ariana Detwiler, Eva Gilker, Alexander C. Ignatious, Srinivasan Vijayaraghavan and Douglas Kline

    Citation: BMC Developmental Biology 2019 19:20

    Content type: Research article

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  11. Mouse NOTCH1 carries a highly conserved O-fucose glycan at Thr466 in epidermal growth factor-like repeat 12 (EGF12) of the extracellular domain. O-Fucose at this site has been shown by X-ray crystallography to...

    Authors: Shweta Varshney, Hua-Xing Wei, Frank Batista, Mohd Nauman, Subha Sundaram, Katherine Siminovitch, Ankit Tanwar and Pamela Stanley

    Citation: BMC Developmental Biology 2019 19:19

    Content type: Research article

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  12. Sonic hedgehog (Shh) is an important signalling protein involved in the induction of early cartilaginous differentiation. Herein, we demonstrate that Shh markedly induces chondrogenesis of rabbit bone marrow s...

    Authors: Liyang Chen, Gejun Liu, Wenjun Li and Xing Wu

    Citation: BMC Developmental Biology 2019 19:18

    Content type: Research article

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  14. The Tet protein family (Tet1, Tet2, and Tet3) regulate DNA methylation through conversion of 5-methylcytosine to 5-hydroxymethylcytosine which can ultimately result in DNA demethylation and play a critical rol...

    Authors: Michael Reimer Jr, Kirthi Pulakanti, Linzheng Shi, Alex Abel, Mingyu Liang, Subramaniam Malarkannan and Sridhar Rao

    Citation: BMC Developmental Biology 2019 19:16

    Content type: Research article

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  15. Prostate androgen-regulated mucin-like protein 1 (PARM1) is a pro-proliferative and anti-apoptotic glycoprotein involved in the endoplasmic reticulum (ER) stress response. A single nucleotide polymorphism in t...

    Authors: Adriana M. Zolini, Verónica M. Negrón-Pérez and Peter J. Hansen

    Citation: BMC Developmental Biology 2019 19:15

    Content type: Research article

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  16. Insulin/insulin-like growth peptide signaling (IIS) down-regulates hemolymph sugar level and facilitates larval growth in the soybean pod borer, Maruca vitrata. The objective of this study is to determine whether...

    Authors: Md. Abdullah Al Baki, Dae-Weon Lee, Jin Kyo Jung and Yonggyun Kim

    Citation: BMC Developmental Biology 2019 19:14

    Content type: Research article

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  17. The segregation of the hypoblast and the emergence of the pluripotent epiblast mark the final stages of blastocyst formation in mammalian embryos. In bovine embryos the formation of the hypoblast has been part...

    Authors: Jesica R. Canizo, Amada E. Ynsaurralde Rivolta, Camila Vazquez Echegaray, Mariana Suvá, Virgilia Alberio, Juan F. Aller, Alejandra S. Guberman, Daniel F. Salamone, Ricardo H. Alberio and Ramiro Alberio

    Citation: BMC Developmental Biology 2019 19:13

    Content type: Research article

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  18. Alterations of bioelectrical properties of cells and tissues are known to function as wide-ranging signals during development, regeneration and wound-healing in several species. The Drosophila follicle-cell epith...

    Authors: Isabel Weiß and Johannes Bohrmann

    Citation: BMC Developmental Biology 2019 19:12

    Content type: Research article

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  19. Progressive transformation of the otic placode into the functional inner ear during gestational development in humans leads to the acquisition of hearing perception via the cochlea and balance and spatial orie...

    Authors: Lejo Johnson Chacko, David Wertjanz, Consolato Sergi, Jozsef Dudas, Natalie Fischer, Theresa Eberharter, Romed Hoermann, Rudolf Glueckert, Helga Fritsch, Helge Rask-Andersen, Anneliese Schrott-Fischer and Stephan Handschuh

    Citation: BMC Developmental Biology 2019 19:11

    Content type: Research Article

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  20. Cell differentiation is mediated by synchronized waves of coordinated expression for hundreds to thousands of genes, and must be regulated to produce complex tissues and phenotypes. For many animal species, se...

    Authors: Damien B. Wilburn and Richard C. Feldhoff

    Citation: BMC Developmental Biology 2019 19:10

    Content type: Research article

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  21. Coilia nasus oogenesis/spawning migration is a well-defined synchronous arrangement process. DnaJs are indispensable molecular chaperones for oogenesis process. However, how DnaJs involved the anadromous spawning...

    Authors: Xiao-ting Feng, Xue-jun Yang, Jian-jian Ruan, Ya-qi Wang, Yan-feng Zhou, Dong-po Xu and Di-an Fang

    Citation: BMC Developmental Biology 2019 19:9

    Content type: Research article

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  22. The interstitium of the mouse testis contains Leydig cells and a small number of steroidogenic cells with adrenal characteristics which may be derived from the fetal adrenal during development or may be a norm...

    Authors: Peter J. O’Shaughnessy, Rod T. Mitchell, Ana Monteiro, Laura O’Hara, Lyndsey Cruickshanks, Hedi Claahsen-van der Grinten, Pamela Brown, Margaret Abel and Lee B. Smith

    Citation: BMC Developmental Biology 2019 19:8

    Content type: Research article

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  23. NK genes are a group of homeobox transcription factors that are involved in various molecular pathways across bilaterians. They are typically divided into two subgroups, the NK cluster (NKC) and NK-linked gene...

    Authors: Sandra Treffkorn and Georg Mayer

    Citation: BMC Developmental Biology 2019 19:7

    Content type: Research article

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  24. C-lectin family 14 Member A (Clec14a) is a transmembrane protein specifically expressed in vascular endothelial cells during embryogenesis. Previous in vitro and in vivo studies have provided conflicting data ...

    Authors: Karolina Pociute, Jennifer A. Schumacher and Saulius Sumanas

    Citation: BMC Developmental Biology 2019 19:6

    Content type: Research article

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  25. The embryonic day E10–13 period of mouse heart development is characterized by robust cardiomyocyte proliferation that creates the compact zone of thickened ventricular wall myocardium. This process is initiat...

    Authors: Kai Wang, Hua Shen, Peiheng Gan, Susana Cavallero, S. Ram Kumar, Ching-Ling Lien and Henry M. Sucov

    Citation: BMC Developmental Biology 2019 19:5

    Content type: Research article

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  26. Knowledge about vitellogenesis in spiders is rudimentary. Therefore, the aim of study was to check the vitellogenin (Vg) presence in various tissues of the female spider Parasteatoda tepidariorum, determine when ...

    Authors: Agata W. Bednarek, Marta K. Sawadro, Łukasz Nicewicz and Agnieszka I. Babczyńska

    Citation: BMC Developmental Biology 2019 19:4

    Content type: Research article

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  27. Organoid cultivation in suspension culture requires agitation at low shear stress to allow for nutrient diffusion, which preserves tissue structure. Multiplex systems for organoid cultivation have been propose...

    Authors: Livia Goto-Silva, Nadia M. E. Ayad, Iasmin L. Herzog, Nilton P. Silva, Bernard Lamien, Helcio R. B. Orlande, Annie da Costa Souza, Sidarta Ribeiro, Michele Martins, Gilberto B. Domont, Magno Junqueira, Fernanda Tovar-Moll and Stevens K. Rehen

    Citation: BMC Developmental Biology 2019 19:3

    Content type: Methodology article

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  28. Work in other species suggests that interleukin-6 (IL6) promotes early embryo development. It was unclear whether IL6 serves as an embryokine in cultured bovine embryos. This work was undertaken to elucidate t...

    Authors: Lydia K. Wooldridge and Alan D. Ealy

    Citation: BMC Developmental Biology 2019 19:2

    Content type: Research article

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  29. BMP signaling is involved in myriad metazoan developmental processes, and study of this pathway in Drosophila has contributed greatly to our understanding of its molecular and genetic mechanisms. These studies ha...

    Authors: Scott J. Neal, Darin Dolezal, Nisveta Jusić and Francesca Pignoni

    Citation: BMC Developmental Biology 2019 19:1

    Content type: Methodology article

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  30. Previous studies have implicated a role for circadian clocks in regulating pre-adult development of organisms. Among them two approaches are most notable: 1) use of insects whose clocks have different free-run...

    Authors: Manishi Srivastava, Anjana James, Vishwanath Varma, Vijay Kumar Sharma and Vasu Sheeba

    Citation: BMC Developmental Biology 2018 18:21

    Content type: Research article

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  31. Histone modifications are critical in regulating neuronal processes. However, the impacts of individual histone modifications on learning and memory are elusive. Here, we investigated the contributions of hist...

    Authors: Kai-Le Li, Lei Zhang, Xiao-Mei Yang, Qiang Fang, Xue-Fang Yin, Hui-Min Wei, Ting Zhou, Ya-Bin Li, Xue-Lin Chen, Fan Tang, Yong-Hao Li, Jian-Feng Chang, Wei Li and Feng Sun

    Citation: BMC Developmental Biology 2018 18:20

    Content type: Research article

    Published on:

  32. Integrins are transmembrane receptors that mediate cell–extracellular matrix (ECM) and cell-cell adhesion and trophoblast cells undergo changes in integrin expression as they differentiate. However, the mechan...

    Authors: Eiko Kawamura, Gina B. Hamilton, Ewa I. Miskiewicz and Daniel J. MacPhee

    Citation: BMC Developmental Biology 2018 18:19

    Content type: Research article

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  34. Mammalian brain is formed through neural tube closure (NTC), wherein both ridges of opposing neural folds are fused in the midline and remodeled in the roof plate of the neural tube and overlying non-neural ec...

    Authors: Naomi Shinotsuka, Yoshifumi Yamaguchi, Kenichi Nakazato, Yudai Matsumoto, Atsushi Mochizuki and Masayuki Miura

    Citation: BMC Developmental Biology 2018 18:17

    Content type: Research article

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  35. Alterations in maternal environment can sometimes affect embryonic development in a sexually-dimorphic manner. The objective was to determine whether preimplantation bovine embryos respond to three maternally-...

    Authors: Paula Tríbulo, Gulnur Jumatayeva, Khoboso Lehloenya, James I. Moss, Veronica M. Negrón-Pérez and Peter J. Hansen

    Citation: BMC Developmental Biology 2018 18:16

    Content type: Research article

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  36. Diabetes and hypothyroidism produce adverse effects on body weight and sexual maturity by inhibiting body growth and metabolism. The occurrence of diabetes is always accompanied with thyroid dysfunction. Thus,...

    Authors: Nazar Ali KOREJO, Quanwei WEI, Kaizhi ZHENG, Dagan MAO, Rashid Ali KOREJO, Atta Hussain SHAH and Fangxiong SHI

    Citation: BMC Developmental Biology 2018 18:15

    Content type: Research article

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  37. Dmrt2a is a zinc finger like transcription factor with several roles during zebrafish early development: left-right asymmetry, synchronisation of the somite clock genes and fast muscle differentiation. Despite...

    Authors: Rita Alexandra Pinto, José Almeida-Santos, Raquel Lourenço and Leonor Saúde

    Citation: BMC Developmental Biology 2018 18:14

    Content type: Research article

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  38. Pregnant women may be exposed to nicotine if they smoke or use tobacco products, nicotine replacement therapy, or via e-cigarettes. Prenatal nicotine exposure has been shown to have deleterious effects on the ...

    Authors: Melanie Morris, Ariel Shaw, Madison Lambert, Haley Halperin Perry, Eve Lowenstein, David Valenzuela and Norma Andrea Velazquez-Ulloa

    Citation: BMC Developmental Biology 2018 18:13

    Content type: Research article

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  39. The proliferating cell nuclear antigen (PCNA or PCN-1 in C. elegans), an essential processivity factor for DNA polymerase δ, has been widely used as a marker of S-phase. In C. elegans early embryos, PCN-1 accumul...

    Authors: Zuzana Kocsisova, Kerry Kornfeld and Tim Schedl

    Citation: BMC Developmental Biology 2018 18:12

    Content type: Research article

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  40. Honeybee development consists of four stages: embryo, larva, pupa and adult. Embryogenesis, a key process of cell division and differentiation, takes 3 days in honeybees. However, the embryonic transcriptome a...

    Authors: Xiaofen Hu, Li Ke, Zilong Wang and Zhijiang Zeng

    Citation: BMC Developmental Biology 2018 18:11

    Content type: Research article

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  41. Male European seabass, already predominant (~ 70%) in cultured stocks, show a high incidence (20–30%) of precocious sexual maturation under current aquaculture practices, leading to important economic losses f...

    Authors: Marco Graziano, Raul Benito, Josep V. Planas and Arjan P. Palstra

    Citation: BMC Developmental Biology 2018 18:10

    Content type: Research article

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  42. In this work we have determined molecular signatures of oviduct epithelial and progenitor cells. We have proposed a panel of selected marker genes, which correspond with the phenotype of oviduct cells of a lay...

    Authors: Katarzyna Stadnicka, Anna Sławińska, Aleksandra Dunisławska, Bertrand Pain and Marek Bednarczyk

    Citation: BMC Developmental Biology 2018 18:9

    Content type: Research article

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  43. The experimental approach to the evolution and development of the vertebrate skeleton has to a large extent relied on “direct-developing” amniote model organisms, such as the mouse and the chicken. These organ...

    Authors: Joost M. Woltering, Michaela Holzem, Ralf F. Schneider, Vasilios Nanos and Axel Meyer

    Citation: BMC Developmental Biology 2018 18:8

    Content type: Research article

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  44. FK506-binding proteins (FKBPs) have become the subject of considerable interest in several fields, leading to the identification of several cellular and molecular pathways in which FKBPs impact prenatal develo...

    Authors: George Ghartey-Kwansah, Zhongguang Li, Rui Feng, Liyang Wang, Xin Zhou, Frederic Z. Chen, Meng Meng Xu, Odell Jones, Yulian Mu, Shawn Chen, Joseph Bryant, Williams B. Isaacs, Jianjie Ma and Xuehong Xu

    Citation: BMC Developmental Biology 2018 18:7

    Content type: Review

    Published on:

  46. Tbx5 deficiency in zebrafish causes several abnormal phenotypes of the heart and pectoral fins. It has been reported that exogenous human growth hormone can enhance expression of downstream mediators in the growt...

    Authors: Tzu-Chun Tsai, Chun-Che Shih, Hsin-Ping Chien, An-Hang Yang, Jenn-Kan Lu and Jen-Her Lu

    Citation: BMC Developmental Biology 2018 18:5

    Content type: Research article

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  47. Germ cell formation has been investigated in sessile forms of tunicates. This process involves the release of a subset of maternal transcripts from the centrosome-attracting body (CAB) in the progenitor cells ...

    Authors: Lisbeth Charlotte Olsen, Ioannis Kourtesis, Henriette Busengdal, Marit Flo Jensen, Harald Hausen and Daniel Chourrout

    Citation: BMC Developmental Biology 2018 18:4

    Content type: Research article

    Published on:

  48. MiR-9 is a small non-coding RNA that is highly conserved between species and primarily expressed in the central nervous system (CNS). It is known to influence proliferation and neuronal differentiation in the ...

    Authors: A. Alwin Prem Anand, Carola Huber, John Asnet Mary, Nancy Gallus, Christoph Leucht, Ruth Klafke, Bernhard Hirt and Andrea Wizenmann

    Citation: BMC Developmental Biology 2018 18:3

    Content type: Research article

    Published on:

  50. The compound eyes of insects allow them to catch photons and convert the energy into electric signals. All compound eyes consist of numerous ommatidia, each comprising a fixed number of photoreceptors. Differe...

    Authors: Leonie Lichtenstein, Kornelia Grübel and Johannes Spaethe

    Citation: BMC Developmental Biology 2018 18:1

    Content type: Research article

    Published on:

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