The iridocorneal angle forms in the mammalian eye from undifferentiated mesenchyme between the root of the iris and cornea. A major component is the trabecular meshwork, consisting of extracellular matrix orga...
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Citation: BMC Developmental Biology 2001 1:3
High copy arrays containing a sequence upstream of mec-3 alter cell migration and axonal morphology in C. elegans
The Caenorhabditis elegans gene mec-3 encodes a LIM-homeodomain protein that is a master regulator of touch receptor neuron genes. Two of the touch neurons, the ALM neurons, are generated in the anterior of the a...Citation: BMC Developmental Biology 2001 1:2
Dynamic expression of a glutamate decarboxylase gene in multiple non-neural tissues during mouse development
Glutamate decarboxylase (GAD) is the biosynthetic enzyme for the neurotransmitter γ-aminobutyric acid (GABA). Mouse embryos lacking the 67-kDa isoform of GAD (encoded by the Gad1 gene) develop a complete cleft of...Citation: BMC Developmental Biology 2001 1:1