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Fig. 7 | BMC Developmental Biology

Fig. 7

From: Wingless and Archipelago, a fly E3 ubiquitin ligase and a homolog of human tumor suppressor FBW7, show an antagonistic relationship in wing development

Fig. 7

Overexpression of Ago increases the level of Wg in ER. Clones that overexpress Ago were generated in wing discs outlined in yellow. Endogenous intracellular Wg was detected with anti-Wg, and the clones were marked with GFP. Boxed area in (a'') and (b'') are magnified in (a''') and (b'''). a More co-localization of Wg and ER marker KDEL is observed in an Ago-expressing clone than neighboring cells (arrows). b Less co-localization of Wg and Golgi marker GM130 is seen in an Ago-expressing clone than neighboring cells (arrows). Scale bars, 5 μm

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