Table 1 Downregulated genes in Nkx2.2-/- versus Nkx2.2+/+ pancreata at e12.5.
From: Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development
Genbank Accession Number | Gene Symbol | Gene Name | e12.5 Fold Change |
|---|---|---|---|
Secreted Factors | Â | Â | Â |
NM_008100 | Gcg | GLUCAGON | -20.0 |
NM_145435 | Pyy | PEPTIDE YY | -7.6 |
NM_007694 | Chgb | CHROMOGRANIN B | -2.0 |
NM_009242 | Sparc | SECRETED ACIDIC CYSTEINE RICH GLYCOPROTEIN | -1.9 |
NM_009258 | Spink3 | SERINE PEPTIDASE INHIBITOR, KAZAL TYPE 3 | -1.8 |
NM_010257 | Gast | GASTRIN | -1.7 |
NM_008343 | Igfbp3 | INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3 | -1.6 |
NM_008386 | Ins1 | INSULIN I | -1.5 |
Transcription Factors | Â | Â | Â |
NM_010919 | Nkx2-2 | NK2 TRANSCRIPTION FACTOR RELATED, LOCUS 2 (DROSOPHILA) | -5.0 |
NM_009719 | Neurog3 | NEUROGENIN 3 | -2.7 |
NM_025824 | Bzw1 | BASIC LEUCINE ZIPPER AND W2 DOMAINS 1 | -1.9 |
NM_010894 | Neurod1 | NEUROGENIC DIFFERENTIATION 1 | -1.9 |
NM_033041 | Hes7 | HAIRY AND ENHANCER OF SPLIT 7 (DROSOPHILA) | -1.8 |
NM_008092 | Gata4 | GATA BINDING PROTEIN 4 | -1.7 |
NM_178083 | Irf6 | INTERFERON REGULATORY FACTOR 6 V-MAF MUSCULOAPONEUROTIC FIBROSARCOMA ONCOGENE | -1.6 |
NM_010658 | Mafb | FAMILY, PROTEIN B (AVIAN) | -1.6 |
NM_019738 | Nupr1 | NUCLEAR PROTEIN 1 | -1.6 |
Transmembrane Proteins | Â | Â | Â |
NM_020626 | Tmem27 | TRANSMEMBRANE PROTEIN 27 | -4.5 |
NM_011695 | Vdac2 | VOLTAGE-DEPENDENT ANION CHANNEL 2 | -2.8 |
NM_011150 | Lgals3bp | LECTIN, GALACTOSIDE-BINDING, SOLUBLE, 3 BINDING PROTEIN | -1.6 |
NM_144926 | Sez6l2 | SEIZURE RELATED 6 HOMOLOG LIKE 2 | -1.6 |
Transporters | Â | Â | Â |
NM_013697 | Ttr | TRANSTHYRETIN | -3.6 |
NM_172479 | Slc38a5 | SOLUTE CARRIER FAMILY 38, MEMBER 5 | -3.2 |
NM_007618 | Serpina6 | SERINE (OR CYSTEINE) PEPTIDASE INHIBITOR, CLADE A, MEMBER 6 | -1.7 |
NM_007423 | Afp | ALPHA FETOPROTEIN | -1.6 |
NM_007443 | Ambp | ALPHA 1 MICROGLOBULIN/BIKUNIN | -1.6 |
Peptidases | Â | Â | Â |
NM_008792 | Pcsk2 | PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 2 | -2.2 |
NM_025583 | Ctrb1 | CHYMOTRYPSINOGEN B1 | -1.8 |
NM_001024698 | Cpa2 | SIMILAR TO CARBOXYPEPTIDASE A2 PRECURSOR | -1.7 |
NM_011909 | Usp18 | UBIQUITIN SPECIFIC PEPTIDASE 18 | -1.6 |
NM_013494 | Cpe | CARBOXYPEPTIDASE E | -1.6 |
NM_146101 | Habp2 | HYALURONIC ACID BINDING PROTEIN 2 | -1.6 |
Signaling | Â | Â | Â |
NM_021356 | Gab1 | GROWTH FACTOR RECEPTOR BOUND PROTEIN 2-ASSOCIATED PROTEIN 1 | -2.5 |
NM_145736 | Pim2 | PROVIRAL INTEGRATION SITE 2 | -1.7 |
NM_009245 | Serpina1c | SERINE (OR CYSTEINE) PEPTIDASE INHIBITOR, CLADE A, MEMBER 1A | -1.6 |
NM_008052 | Dtx1 | DELTEX 1 HOMOLOG (DROSOPHILA) | -1.5 |
Metabolism | Â | Â | Â |
NM_018874 | Pnliprp1 | PANCREATIC LIPASE RELATED PROTEIN 1 | -2.5 |
NM_001081070 | Pdia2 | PROTEIN DISULFIDE ISOMERASE ASSOCIATED 2 | -2.1 |
NM_009040 | Rdh16 | RETINOL DEHYDROGENASE 16 | -1.5 |
Translation | Â | Â | Â |
NM_008774 | Pabpc1 | POLY A BINDING PROTEIN, CYTOPLASMIC 1 | -1.5 |
Other | Â | Â | Â |
CV676831 | 9330162012Rik | CDNA RIKEN 9330162012 GENE | -3.3 |
CF585856 | IMAGE = 6430431 | Unknown | -3.3 |
NM_026791 | Fbxw9 | F-BOX AND WD-40 DOMAIN PROTEIN 9 | -2.8 |
CF582515 | IMAGE = 6432606 | Unknown | -2.6 |
NM_026479 | Zcchc10 | ZINC FINGER, CCHC DOMAIN CONTAINING 10 | -2.0 |
NM_010058 | Dmwd | DYSTROPHIA MYOTONICA-CONTAINING WD REPEAT MOTIF | -1.9 |
NM_134013 | Psme4 | PROTEASOME (PROSOME, MACROPAIN) ACTIVATOR SUBUNIT 4 | -1.6 |
NM_198000 | 1700001O22Rik | RIKEN CDNA 1700001O22 GENE | -1.6 |
NM_025946 | 2010100O12Rik | RIKEN CDNA 2010100O12 GENE | -1.6 |