Figure 2

corto regulates wing tissue differentiation in interaction with blistered ( bs) and rhomboïd ( rho ). (A): Wings from corto^07128b/+ flies exhibit ectopic veins (shown by asterisks) within intervein tissue (L1-L5: longitudinal veins; ACV and PCV: anterior and posterior cross-veins). (B, C, D): This phenotype is more severe in flies heteroallelic for corto loss-of-function mutations (corto^07128b/corto^L1; corto^07128b/corto⁴²⁰; corto ^L1/Df(3R)6-7 ). (E): corto over-expression induces ectopic veins (shown by asterisks). (F to J): corto^07128b enhances the ectopic vein phenotype (shown by asterisks) and the blistered phenotype (shown by arrows) induced by the bs^EY23316 loss-of-function allele (F, G, H) and by rho over-expression using the rho^EP3704 allele (I, J). (K, L): in situ hybridization of 30 h pupal wings from corto^L1/Df(3R)6-7 mutants with bs probe (K) or rho probe (L); white asterisks point to bs and rho deregulation.