Skip to main content

Table 1 Embryonic lethality of Notch1[12f/12f] after backcrossing to C57BL/6 J

From: A modifier in the 129S2/SvPasCrl genome is responsible for the viability of Notch1[12f/12f] mice

Cross Intercross Pairs (Litters) Notch1 [+/+] Notch1 [12f/+] Notch1 [12f/12f] Chi-Squared Test
Toronto Notch1[12f/+] X Toronto Notch1[12f/+] 5 (8) 18 36 14  
Expected ratio   17 34 17 P = 0.7
Backcrossed 11 generations (1st cohort) 19 (65) 103 178 13  
C57BL/6 J.Notch1[12f/+]
X
C57BL/6 J.Notch1[12f/+]
Expected ratio   74 147 74 P = 1.57e-15
Backcrossed 15 generations (2nd cohort) 9 (9) 19 33 2  
C57BL/6 J.Notch1[12f/+]
X
C57BL/6 J.Notch1[12f/+]
Expected ratio   14 27 14 P = 0.0013