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Table 1 Effect of low dose of PD0325901 in bovine embryos

From: A dose-dependent response to MEK inhibition determines hypoblast fate in bovine embryos

Treatments N Total cells ICM TE ICM:TE
DMSO 7 246 ± 24b 78 ± 13a 166 ± 14b 0,47 ± 0,12 a
PD032 (0.4 μM) 4 282 ± 29a 58 ± 10b 224 ± 20a 0,26 ± 0,07 b
PD032 (1 μM) 6 277 ± 27a 49 ± 9b 228 ± 20a 0,21 ± 0,06 c
PD032 (2 μM) 9 270 ± 26a 39 ± 7c 230 ± 20a 0,17 ± 0,05 d
  1. Number of inner cell mass (ICM), trophectoderm (TE) and total cells in embryos cultured under different conditions. Results are from three biological replicates. “N” is the number of embryos analyzed. Values are mean ± S.E. estimated by a GLMM analysis with Poisson distribution and log as link function (for Total Cells, ICM and TE), and with Binomial distribution with logit as link function for (ICM:TE ratios). Different letters denote significant differences, p < 0.05