Fig. 4
From: Dynamics of promoter bivalency and RNAP II pausing in mouse stem and differentiated cells
Promoter dynamic across cell types and chromatin states. a Hierarchical clustering of the average profile signals across clusters results in the identification of 9 major profile sub-groups. b Significant chromatin state transitions across cell types and clusters. Four major chromatin state changes across cell type pairs emerged, namely H3K27me3-only <− > bivalent-wide-H3K27me3, H3K27me3-only <− > bivalent-narrow-H3K27me3, bivalent-narrow-H3K27me3 < −> bivalent-active and bivalent-active <− > highly-active. c Bivalent-wide-H3K27me3 cluster 3 promoters in ESCs overlapped highly H3K27me3-only cluster 1 promoters in B cells and were enriched for ‘pattern specification process’ (P value < 10− 30). Bivalent-narrow-H3K27me3 cluster 5 promoters in ESCs overlapped highly with bivalent-wide-H3K27me3 cluster 3 promoters in B cells and were enriched for ‘Nervous system development’ (P value < 10− 30). Highly-active cluster 19 promoters in ESCs overlapped highly with boundary-H3K27me3-active cluster 17 promoters in B cells and were enriched for ‘ncRNA metabolic process’ (P value < 1.7.10− 23). d Significant sets of genes overlapping in 3 distinct cell types and clusters. 98 genes enriched for ‘cell fate commitment’ (P value < 3.2.10− 7) were present in B cells in cluster 1, in DCS in cluster 2 and in BMDMS in cluster 3