Table 2 Tissue-specific Cre recombinase drivers and their relationship to cardiovascular lineages

Sox2Cre [19]

6.5

Epiblast

All embryonic tissues.

Wnt1Cre [15, 51]

8.5

Neural crest

Aorticopulmonary septum, conotruncal cushions, 3^rd, 4^th and 6^th pharyngeal arch arteries.

Hoxa3Cre [22, 44, 52]

E8.0 - E9.0

Pharyngeal arch lineages (endo, meso and ectoderm), caudal to the second arch (PA 3–6).

Pharyngeal arch arteries (smooth muscle cells), myocardium of a distal outflow tract and the base of the pulmonary trunk, outflow tract cushions.

Mesp1Cre [31,32,33]

6.5–7.0

Extraembryonic, lateral, cranio-cardiac, and pharyngeal mesoderm.

Myo-, endo- and epicardium, pharyngeal arch arteries.

Nkx2.5Cre [21, 36, 38]

7.5–7.75

Myocardial precursors of primary and secondary heart fields, pharyngeal endoderm and ectoderm of the first pharyngeal arch, proepicardium.

Myocardium; endothelium of coronary arteries, cardiac chambers, and valves; smooth muscle cells of the aorta and coronary arteries.