Genotype | ASD | VSD only | Overriding Aortab
| Gerbode’s defect | AVSDc
| No defect | Total mice |
---|
Tbx5
+/−
| 11 (27.5Â %) | 10 (25Â %) | 7 (17.5Â %) | 4 (10Â %) | 2 (5Â %) | 13 (32.5Â %) | 40 |
Ts65Dn; Tbx5
+/−
| 12 (38.7Â %) | 6 (19.4Â %) | 18 (58.1Â %) | 6 (19.4Â %) | 6 (19.4Â %) | 5 (16Â %) | 31 |
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aSeveral animals had more than one defect. (see Additional file 1: Table S1)
-
bThere is a significant difference between euploid and trisomic Tbx5 heterozygous mice in the occurrence of overriding aorta (p = 0.0004)
-
cThe difference between euploid and trisomic Tbx5 heterozygous mice in AVSD is approaching significance (p = 0.07)