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Fig. 9 | BMC Developmental Biology

Fig. 9

From: Key pathways regulated by HoxA9,10,11/HoxD9,10,11 during limb development

Fig. 9

Immunofluorescent staining of E15.5 Wild type HoxAADD (ad) and mutant Hoxaadd (Hoxa9,10,11 −/−;Hoxd9,10,11 −/−) (eh) forelimbs. Arrowhead: radius, Arrow: ulna, the autopod is oriented to the left of the image. a and e: Six2 immunostaining, showing an increased expression in mutant chondrocytes. b and f: Gas1 staining, showing an increase in mutant limbs that is restricted to cells flanking chondrocytes, consistent with the inclusion of some perichondrial cells in the LCM samples. c and g: Lef1 staining, showing an absence of staining in mutant chondrocytes. d and h: Runx3 staining, showing an absence of staining in mutant chondrocytes

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