Fig. 8
From: Key pathways regulated by HoxA9,10,11/HoxD9,10,11 during limb development
Heatmap comparison of Hox mutant and resting wild type gene expression patterns. The 61 genes with the greatest fold change (≥3) are shown. The most strongly down-regulated genes in aadd (Hoxa9,10,11 −/−;Hoxd9,10,11 −/−) mutants include Lef1, Shox2 and Runx3. The most strongly up-regulated genes include Sall1, Six2, Gas1, Gas2 and Osr1