Figure 1

Remodeling of the pancreatic epithelial cell mass into polarized monolayers. Pancreatic sections from e10.5 to e15.5 embryos were examined by immunofluorescence using antibodies directed against E-cadherin, mucin-1 and laminin. Pancreatic development starts by the formation of a mass of non-polarized epithelial cells (e10.5-e11.5). This mass is then remodeled (e12.5-e13.5) and finally every epithelial cell become polarized, with its basal pole contacting laminin and its apical pole facing a lumen (e14.5-e15.5). * indicates the central duct, in connection with the duodenum. Scale bar, 100 μm.