Figure 6

Expression of Tle1, Tle2, Tle3 and Tle4, in relation to Pdx1, Nkx2-2, Insulin, Glucagon, Pancreatic polypeptide (PP), and Somatostatin expression, in the E18.5 pancreas. Saggital sections of E18.5 pancreases were analyzed for the expression of (A, E, I, M, Q, U) Tle1, (B, F, J, N, R, V) Tle2, (C, G, K, O, S, W) Tle3 or (D, H, L, P, T, X) Tle4 (green) in relation to (A, B, C, D) Pdx1, (E, F, G, H) Nkx2-2, (I, J, K, L) Insulin, (M, N, O, P) Glucagon, (Q, R, S, T) PP, or (U, V, W, X) Somatostatin expression (red). Blue arrows indicate cells that are Gro/TLE + but without co-localization, while yellow arrows indicate cells where the Gro/TLE proteins co-localize with Pdx1, Nkx2-2, Insulin, Glucagon, PP, or Somatostatin as appropriate, and green arrows indicate cells that express Pdx1, Nkx2-2, Insulin, Glucagon, PP, or Somatostatin, as appropriate, in the absence of Gro/TLE protein. Sections were photographed at ×200.