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Table 3 Over-represented gene ontologies.

From: Identification of genes associated with regenerative success of Xenopus laevishindlimbs

GO Term

No. on array/total genes

No. >2x up-regulated

p

Gene ontology description

Contributing gene TC numbers

  

Fraction

% genes on array

   

GO:0030150

5/13094

4/98

80%

1.47E-08

Protein import into mitochondrial matrix

TC261859, TC262099, TC275000, TC275032

GO:0006626

22/13094

5/98

23%

5.04E-07

Protein targeting to mitochondrion

TC261859, TC261956, TC262099, TC275000, TC275032

GO:0006457

82/13094

6/98

7%

3.33E-05

Protein folding

TC261741, TC261742, TC261767, TC262099, TC263531, TC275000

GO:0009408

27/13094

4/98

14%

4.54E-05

Response to heat

TC261767, TC262099, TC275000, TC275946

GO:0006458

2/13094

2/98

100%

5.54E-05

De novo protein folding

TC261859, TC275032

GO:0006628

2/13094

2/98

100%

5.54E-05

Mitochondrial translocation

TC261859, TC275032

GO:0042026

6/13094

2/98

33%

0.001

Protein refolding

TC262099, TC263531

GO:0040007

58/13094

4/98

7%

0.001

Growth

TC2612741, TC261742, TC262099, TC275000

GO:0006364

29/13094

3/98

10%

0.001

rRNA processing

TC261435, TC275446, TC285474

GO:0007098

8/13094

2/98

25%

0.002

Centrosome cycle

TC263531, TC274052

GO:0009792

96/13094

4/98

4%

0.006

Embryonic development (metazoa)

TC261741, TC261742, TC262099, TC288722

GO:0040010

60/13094

3/98

5%

0.010

Positive regulation of growth rate

TC261741, TC261742, TC288722

GO:0015671

8/13094

5/295

63%

2.97E-07

Oxygen transport

TC262354, TC275583, TC275773, TC279855, TC289552

GO:0045104

10/13094

4/295

40%

4.76E-05

Intermediate filament organisation and biogenesis

TC260221, TC263972, TC286967, TC287917

GO:0030573

2/13094

2/295

100%

0.001

Bile acid catabolic process

TC264038, TC265106

GO:0015721

2/13094

2/295

100%

0.001

Bile acid transport

TC264038, TC265106

GO:0008544

38/13094

5/295

13%

0.002

Epidermis development

TC260221, TC263972, TC286967, TC287917, TC289357

GO:0000902

23/13094

4/295

17%

0.002

Cell morphogenesis

TC263972, TC286967, TC287917, TC289357

GO:0007155

109/13094

8/295

7%

0.003

Cell adhesion

TC260941, TC264675, TC274819, TC275243, TC275517, TC287476, TC288397, TC288694

GO:0006796

15/13094

3/295

20%

0.004

Phosphate metabolic process

TC265197, TC274479, TC292101

GO:0006810

234/13094

12/295

5%

0.007

Transport

TC262354, TC264038, TC264071, TC265834, TC271905, TC275007, TC275583, TC275773, TC276787, TC279855, TC288559, TC289552

GO:0006694

6/13094

2/295

33%

0.007

Steroid biosynthetic process

TC264038, TC265106

  1. Gene ontology terms (biological function) shown to be statistically over-represented (p < 0.01) in the WT (regenerating, top section) or the N1 (non-regenerating, bold, lower section) 2-fold up-regulated or more lists. TC numbers are tentative consensus numbers for the Affymetrix X. laevis GeneChip assigned by Resourcerer [29], around 1/3 of the genes on the chip were annotated using this method.