Figure 5

Aberrant hippocampus and cingulate cortex in Nfix -/- mice. Comparison of the shape of the hippocampus and cingulate cortex in P28 WT +/+ (A-D) and Nfix-/- (E-H) brains. A) Image of a dorsal view of the brain of a +/+ mouse. Scale bar = 5 mm. B) Coronal section of the +/+ brain at the anterior pole of the hippocampus at about Bregma -0.94. The arrowhead indicates the dentate gyrus. C) Coronal section of the +/+ brain at about Bregma -1.70. The arrowhead indicates the dentate gyrus and the arrow the dorsal most point of the hippocampus. D) Coronal section of the +/+ brain at about Bregma -2.92. The arrowhead indicates the dentate gyrus. E) Image of a dorsal view of the brain of an Nfix-/- mouse. Scale bar = 5 mm. Note the difference in A-P extent and the difference in shape of the cerebellum compared to A. F) Coronal section of the -/- brain at about Bregma -0.94. The arrowhead indicates the dentate gyrus. G) Coronal section of the -/- brain at about Bregma -1.70. The arrow indicates the dorsal enlargement of the hippocampus and the arrowhead the shortened dentate gyrus. H) Coronal section of the -/- brain at about -2.92. The arrowhead indicates the medial end of the external capsule. Scale bar = 2 mm for B-D and F-H.