Figure 2
From: RBM19 is essential for preimplantation development in the mouse
Rbm19GtXC768/GtXC768embryos undergo morula arrest. (A) Live stereoscope images of Rbm19GtXC768/+, Rbm19+/+ or Rbm19GtXC768/GtXC768E3.5 embryos (confirmed subsequently by genotyping). Homozygous mutants fail to form an inner cell mass (+), trophectoderm cell layer (arrow head), and blastocoel cavity (*). (B) Live images of embryos cultured in vitro. Embryos derived from Rbm19GtXC768/+ intercrosses were explanted at E3.5 (day 0), and grown in KSOM for the indicated number of days. Approximately 25% of the embryos arrested in the morula stage; the others hatched from the zona pellucida (Day 2) and continued to develop.