Figure 4From: Neurotransmitter alterations in embryonic succinate semialdehyde dehydrogenase (SSADH) deficiency suggest a heightened excitatory state during developmentConcentrations of glutamate and glutamine in embryo extracts as a function of age. Embryos were grouped as E15–17, 18–19 and day of life 1 (P1). Abbreviations: wt, wild-type (Aldh5a1+/+ mice); mu, mutant (Aldh5a1-/- mice). Statistical analysis performed using a two-tailed t test. One-way ANOVA with Tukey post-hoc analysis revealed a significant decline in glutamate level at birth as compared to E15–17 and E18–19, whereas glutamine levels were not significantly decreased.Back to article page