Table 1 Expression of BLIMP1, PRMT5 and dimethylated histone H4/H2A in normal and neoplastic testicular tissues
BLIMP1 | PRMT5 | H4R3me2s/H2Ame2s | |
|---|---|---|---|
Normal fetal testis | |||
Gonocytes | +++ (n) | +++ (n,c) | +++ (n) |
Pre-spermatogonia | - | - | |
Normal adult testis (N = 18) | |||
Spermatogonia | - | - | ++ (n) |
Pachytene spermatocytes | - | + (n) | - |
Round spermatids | + (n,c) | ++ (n) | ++ (n) |
Elongated spermatids | - | - | - |
Testicular germ cell tumors | |||
IGCNU (N = 15) | +++ (n) 85–100% | +++ (c) 75–95% | +++ (n) 90–100% |
Seminoma (N = 20) | ++ (n) 10–75% | ++ (n+c) 30–85% | ++ (n) 20–80% |
Embryonal carcinoma (N = 15) | +/-(c)* 15–80% | ++ (c) 15–80% | (+)* |
Teratoma (N = 5) | + (n, c) | + (n, c) | + (n) |
Chorioncarcinoma (N = 3) | + (c) | - | - |