Figure 7
From: Generation of FGF reporter transgenic zebrafish and their utility in chemical screens
Specificity of Indolinones towards FGFR versus VEGFR signalling. (A-H) Lateral trunk views of 32 hpf Tg(Fli1:EGFP)y1 embryos treated with the chemicals shown on the bottom left. (A) DMSO control shows embryo with normal expression of EGFP within the intersegmental vessels. (B) 20 μM SU1433, (C) SU11652, (D) SU4312 (E) Oxindole I, (F) SU5402, and (G) SU5416 all suppressed ISV outgrowth as indicated by red arrows. (H) SU6656 in contrast did not alter ISV formation.