Figure 4
The effects of taurine on LTP induction in P60–75 groups. (A) Representative traces were recorded from P60–75 Con, Con+Tau, Lead, Lead+PW-Tau, Lead+WL-Tau and Lead+PL-Tau slices before (a) and 60 min after (b) HFS was applied. (B) The LTP amplitude in Lead group was significantly decreased relative to Con group (Lead: 117.1 ± 4.7%, n = 8; Con: 134.0 ± 5.4%, n = 9, p < 0.01). (C) No significant difference in LTP induction was found between Con and Con+Tau groups (Con: 134.0 ± 5.4%, n = 9; Con+Tau: 131.0 ± 4.0%, n = 8, p > 0.05). (D) The LTP amplitudes in the Lead+PW-Tau, Lead+WL-Tau and Lead+PL-Tau groups were all significantly increased relative to the Lead group (Lead: 117.1 ± 4.7%, n = 8; Lead+PW-Tau:143.3 ± 8.2%, n = 8; Lead+WL-Tau: 131.2 ± 5.3%, n = 10; Lead+PL-Tau: 133.9 ± 5.2%, n = 8; p < 0.01), but were statistically indistinguishable from that of Con group (Con: 134.0 ± 5.4%, n = 9; p > 0.05). Moreover, there were no significant differences in LTP induction among three lead-exposed with taurine supplement groups (p > 0.05). (E) Histogram showing mean ± SEM percentage of fEPSP slope in 40–60 min normalized to the baseline response after HFS in six P60–75 groups. *p < 0.01, versus Lead group, respectively. **p < 0.01, compared with Con group. One-way ANOVA with the Bonferroni post hoc test were used for statistical analysis.