Figure 9
From: Wnt/β-catenin signaling is required for development of the exocrine pancreas
β-catenin KO results in a characteristic transcriptional signature in E14.5 and 16.5 pancreata. Panel A depicts a heat map demonstrating differing transcriptional profiles of Wt and β-catenin KO pancreata at E 14.5 and 16.5. Two wildtype and 4 knockout samples for each timepoint are depicted. Panel B shows quantitative RT-PCR results confirming the loss of PTF1 expression following β-catenin KO detectable as early as E12.5.