Figure 6

Abrogation of Necdin imparts neuritic extension in explants DRGs. (A, B) Photomicrographs of DRGs from E13.5 wild type (A), and Necdin mutant (B) embryos, cultured for 20 hr in the presence of NGF only (100 ng/ml). In three separate experiments, performed in four mutant and wild type lumbar DRGs, significant NGF effect was observed in explants derived from Necdin mutants (C). Scale bar: 100 μm (A and B).