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Figure 7 | BMC Developmental Biology

Figure 7

From: Penetrance of eye defects in mice heterozygous for mutation of Gli3 is enhanced by heterozygous mutation of Pax6

Figure 7

Summary of possible interactions between Gli3 and Pax6 in Shh signalling. The processing of Gli3 to its cleaved form (Gli3CL) from its full-length form (Gli3FL) is inhibited by Shh. Levels of Pax6 are regulated by levels of Gli3CL by a process of double repression, perhaps involving Pax2 and Vax1, such that lowering levels of Gli3CL lowers Pax6 levels. Pax6 negatively regulates Shh expression: thus, lowered Pax6 levels increase Shh's repression of Gli3CL production.

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BMC Developmental Biology

ISSN: 1471-213X

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