Figure 2
From: Alterations in gene expression in T1α null lung: a model of deficient alveolar sac development
Lung phenotype in T1α null mice is apparent after E15.5. H & E staining of (A-D) T1α (+/+) and (E-H) T1α (-/-) lungs at E11.5, 15.5, 18.5, and 19.5 respectively Bar = 100 μm. (I-K) T1α (+/+) at E15.5, E18.5 and E19.5 (L-M) T1α (-/-) at E15.5, E18.5 and E19.5 Bar = 25 μm. Similar lung morphology is observed in T1α (+/+) and T1α (-/-) lungs at E11.5 and 15.5. The phenotype is more severe after E18.5. Thereafter, the lungs exhibit narrower airspaces and thicker mesenchyme. P, pleura; E, epithelium; A, alveolar space.