Figure 8
Expression of plexins and neuropilins in the spinal cord at stage 35. Plexins became more restricted during late stages of spinal cord development. Motor neurons expressed plexinA1, A2, npn-1, and npn-2 in a subpopulation-specific manner (open arrowhead). PlexinA2 expression levels were very high in the dorsal horn (arrowhead), whereas plexinA4 was found only in a restricted area of the lateral dorsal horn. PlexinC1 was still found throughout the gray matter. In contrast to earlier stages, npn-1 was now expressed in the dorsal spinal cord (arrowhead). Expression of plexinA1, A2, A4, C1, and npn-1 in DRGs is indicated by asterisks. Bar 500 μm.