Figure 6

Fgfr2c^+/Δ/ Fgf10^+/- double heterozygous mutant SMG is severely hypoplastic. A. Newborn R2c^+/+/Fgf10^+/+ WT SMG. B. Newborn R2c^+/Δ/Fgf10^+/+ (Fgfr2c^+/Δ/Fgf10^+/+) single heterozygous mutant SMG. C. Newborn R2c^+/+/Fgf10^+/-(Fgfr2c^+/+/Fgf10^+/-) single heterozygous mutant SMG. D. Newborn R2c^+/Δ/Fgf10^+/-(Fgfr2c^+/Δ/Fgf10^+/-) double heterozygous mutant SMG. The Fgfr2c^+/Δ/Fgf10^+/+ (B) and Fgfr2c^+/+/ Fgf10^+/- (C) single heterozygous SMGs have fewer ducts and terminal buds than seen in WT littermates (A). A much smaller, severely hypoplastic gland is seen in Fgfr2c^+/Δ/Fgf10^+/- double heterozygous mice (D) compared to Fgfr2c^+/Δ/Fgf10^+/+ (B) and Fgfr2c^+/+/Fgf10^+/- (C) littermates. Bar, 50 μm.