Figure 4
From: Regulation of signaling genes by TGFβ during entry into dauer diapause in C. elegans
Model for gene regulatory events under the control of TGFβ signaling. Transcriptional regulatory events suggested by expression data in this paper are indicated in red. The TGFβ pathway is shown in green; DAF-3 and DAF-5 form a transcription factor complex that function in neurons to control dauer entry [9]. DAF-3 and DAF-5 are shown regulating DAF-9 and DAF-12 indirectly because these genes are likely to be regulated in non-neuronal tissues. Insulin genes are shown as directly regulated by DAF-3 and DAF-5, but it is equally likely that these genes are regulated by feedback from the insulin pathway or by DAF-12.