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Table 1 Genes differentially regulated by Wnt-5a/Rfz-2 and Wnt-1 in C57mg cells.

From: Stromelysin-1 and mesothelin are differentially regulated by Wnt-5a and Wnt-1 in C57mg mouse mammary epithelial cells

nd, not determined
   Avg. fold changes
Functional Category of Genes GenBank acc. no. Wnt-5a Rfz-2 Wnt-1
   Microarray Quant. RT-PCR Microarray Quant. RT-PCR
Cell Growth/Differentiation
BMP-4 L47480 -3 -2.4 1.4 1.2
Cell Adhesion
plasminogen activator inhibitor-1 M33960 -2.8 -2.4 2.1 1.2
osteoblast specific factor 2 D13664 -2.4 -1.6 1.4 1.1
Flt4 ligand U58112 3.3 2 1 1.2
fibronection ET62894 2 nd -1.8 nd
HTK ligand L38847 -2.1 -1.9 2.5 3.2
mesothelin D86370 -4 -2.9 8.4 2.8
stromelysin 1 X66402 3.8 4.4 -1.6 -2.5
Transcriptional Regulator
groucho-related gene 1 protein U61362 -2.1 -1.6 1.4 -1.4
retinoic acid receptor-alpha X57528 -2.3 -2 1 -1.3
Id4 helix-loop-helix protein X75018 -4.1 -3.6 1.6 -1.1
neural-restrictive silencer factor U13878 -3.5 1.1 1.6 1.8
bcl-3 M90397 1.9 2.2 -2 -1.4
Krox-20 X06746 -3.4 -1.7 6.2 1.5
Inflammation
PTX3 X83601 -2.5 -2.1 1.6 1.6
bradykinin B1 subtype receptor U47281 -2.5 4 2.7 3.2
Signaling
Rho-associated protein kinase U58513 -1.2 nd -4.9 nd
guanine nucleotide-binding protein W83658 1.6 1.7 -4.4 -4.4
signaling molecule (ATTP) U97571 -1.3 1.5 -3.5 -2.7
son of sevenless 1 Z11574 2.5 2.9 -2.6 -2
SHPS-1 D87967 -2.7 -1.4 3 -1.7
TRAF1 L35302 2.6 1.5 2 1.7
Cell surface receptor
interleukin 2 receptor gamma U21795 2 2.7 -1.4 1.9
transferrin receptor X57349 -1.6 -1.6 -2.3 -1.9
Cytokine
interleukin-6 X54542 2.1 -1.1 1.6 1
Cell Cycle
Ki-67 antigen ET62993 -1.45 -1.1 -6.5 -5.8
Axon Guidance
semaphorin F X97817 2.5 3.1 -2 -4
DM-GRASP L25274 3.3 1.8 -2.8 -2.6
  1. Acc., accession; Avg., average; Quant., quantitative; BMP-4, bone morphogenetic protein-4; HTK ligand, hepatoma transmembrane kinase ligand; PTX3, pentraxin 3; SHPS-1, src homology protein substrate-1; TRAF1, TNF receptor associated factor-1. Shown is a list of genes that are differentially regulated by Wnt-5a/Rfz2 and Wnt-1 in C57mg cells identified by DNA microarray analysis. The values determined by DNA microarray analysis were validated using quantitative RT-PCR. Average fold changes from DNA microarray analysis and quantitative RT-PCR were determined from two independent experiments and from three independent experiments performed in triplicate respectively.