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Table 1 Effect of cyclopamine on length of regenerating tail

From: Notochord-derived hedgehog is essential for tail regeneration in Xenopus tadpole

 

Day 3

Day 5

Chemicals

ET

TO

CP

CP + PM

ET

TO

CP

CP + PM

Number

11

11

12

11

9

9

12

10

Mean (μm)

725.3

785.2

401.2

487

1528.8

1751.6

718.4

1168.2

SD

209.3

225.7

171.9

134.1

375.2

408.1

219

293.1

P-value (ET)

-

0.26

0.2 E-4

2.4 E-3

-

0.12

2.7 E-6

1.6 E-2

P-value (TO)

-

-

7.5 E-5

6.1 E-4

-

-

2.2 E-7

1.1 E-2

P-value (CP)

-

-

-

0.1

-

-

-

2.7 E-4

  1. Tail-amputated st. 48 tadpoles were maintained in water containing ethanol (ET, 0.1%), tomatidine (TO, 2.5 μM) or cyclopamine (CP, 2.5 μM) or cyclopamine plus purmorphamine (PM, 0.25 μM). Mean length of the regenerated tails was determined at day 3 and day 5. Student’s t-test was used to identify differences between indicated groups.
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BMC Developmental Biology

ISSN: 1471-213X

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