Functional modelling of planar cell polarity: an approach for identifying molecular function

Table 1 Comparison of model and experimental phenotypes

Genotype		Model function				Polarity phenotype				References
Clone	Background	m_asym	K^align	CG	Clone	Generic name	Figure	Adjacent to clone	Far from clone
none	WT				none	Wildtype		Proximodistal	Proximodistal
fz	WT				Att	Attractive DNA	4A	Inward	Proximodistal	[8]
vang	WT				Rep	Repulsive DNA	4B	Outward	Proximodistal	[11]
fj	WT				Rep	Repulsive DNA	4B	Outward	Proximodistal	[43]
fz+	dsh	PH			Rep	Repulsive weak DNA	5A (Arrows reversed)	Outward	None	[14] (PH)
fz	fmi		H		Att/Rep	Autonomous	5B	Proximodistal	Proximodistal	[36] (H)
fz	dsh		H		Att/Rep	Autonomous	5B	Proximodistal	Proximodistal	[37] (H)
fz	Vang		H	H	Att	Autonomous	5B + 5C	Proximodistal	Swirling	[11] (H)
Vang	fz		H	H	Rep	Autonomous	5B + 5C	Proximodistal	Swirling	[11] (H)
fz	ds			PH/H	Att	Attractive enhanced DNA	5C	Inward	Swirling	[22, 35] (PH)/[38] (H)
fz	pk ^pk			H	Att	Attractive enhanced DNA	5C	Inward	Swirling	[39] (H)
fz+	pk ^pk-sple			PH	Rep	Repulsive enhanced DNA	5C	Outward	Swirling	[14] (PH)
fz+	ft			PH	Rep	Repulsive enhanced DNA	5C	Outward	Swirling	[22] (PH)
fz	Vang	PH	PH		Att	No polarity	6A	None	None	[14] (PH)
vang	fz	PH	PH		Rep	No polarity	6B	None	None	[14] (PH)
fz+	dsh	PH		PH	Rep	Repulsive weak DNA	6B	Outward	None	[14] (PH)
			none	none		Random	6C	Random	Random	Not observed to date

Model function is either assumed to be wild type (left blank), knocked out as supported by adult hair (H) or pre-hair initiation (PH) observations. Domineering non-autonomous is abbreviated to DNA.

ISSN: 1471-213X