Figure 7
From: Functional modelling of planar cell polarity: an approach for identifying molecular function
Inferred and consensus functional roles of polarity proteins. The top section (A) indicates proteins involved in a mediation or global cue role. We are unable to distinguish between the two using only our model. The lower section (B) indicates proteins with roles in polarity transmission or generation. Proteins located at the cell edge in the lower section are involved in transmitting polarity between cells (model: Kalign ). Proteins located in the centre are involved in generating intrinsic polarisation (model: m asym ). Proteins are also grouped into those required to generate cell proximal and distal ends (as seen in the wildtype). Green colouring indicates the roles predicted by the model and red indicates roles concluded form other evidence. Mixed red and green indicates that the model prediction is consistent with other evidence. Yellow with hair indicates a role predicted from adult hair data.