Figure 7

αPS3 Integrin interacts with mutations in genes for adhesion and adhesion signaling. Cardioblast position at stage 17 is visualised for embryos zygotically and maternally heterozygous for both scb² and zygotically heterozygous for an interacting gene. Embryos haplosufficient for scb have normal heart assembly (A). If additionally heterozygous for the gene for βPS1 Integrin (mys¹), the continuity (asterisks) and alignment (arrows) of the CBs is disrupted (B). A similar phenotype is seen in embryos also heterozygous for collagen IV (vkg^[p1003-8], C), whereas mutation in two Laminin chains (LanA ^9-32, D and Lamininα2, or wb^SF11, E) affect CB alignment, but without effect on continuity. Genetic interactions are revealed with a haplosufficiency in adhesion second messengers associated with Integrin, such as Talin (rhea¹, F) and ILK (G), as well with second messengers associated with guidance signaling, such as Disabled (dab^M54-R1, H). CBs labeled with the B2-3-20 enhancer trap. Anterior at top