3D-FISH analysis of embryonic nuclei in mouse highlights several abrupt changes of nuclear organization during preimplantation development

Table 1 Distribution of pericentromeric signals in fPN and mPN during the 1-cell stage

	Female PN (fPN)		Male PN (mPN)
	No. of NPBs	No. of NPBs not associated with pericentromeric signals	No. of NPBs	No. of NPBs not associated with pericentromeric signals
PN1/PN2	5.9 ± 2.6 ^a	1.0 ± 1.7	13.94 ± 4.6 ^a’	8.8 ± 8
(n = 16)	5.9 ± 2.6 ^a	1.0 ± 1.7	13.94 ± 4.6 ^a’	8.8 ± 8
PN3	2.8 ± 2.0 ^b	0.08 ± 0.3	7.8 ± 4. 1 ^b’c	2.5 ± 2.0
(n = 18)	2.8 ± 2.0 ^b	0.08 ± 0.3	7.8 ± 4. 1 ^b’c	2.5 ± 2.0
PN4/PN5	3.9 ± 2.3 ^b	0.2 ± 0.8	5.7 ± 3 ^b’c	1.1 ± 1.1
(n = 42)

Values with superscripts a and a’ are significantly different at p < 0.0001.
Values with superscripts b and b’, and c and c’ are significantly different at p = 0.002.
Values with superscripts a and b are significantly different at p < 0.001.
Values with superscripts c are significantly different at p = 0.05.

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