Table 4 Pathways enriched in secondary Hoxa1 interactors
From: Protein interactions of the transcription factor Hoxa1
Pathway name | ID* | Obs$ | Odds ratio£ | FDRμ | Corr FDR§ | Source | Gene symbols | Entrez gene IDs |
|---|---|---|---|---|---|---|---|---|
RXR and RAR hetrodimerization with other nuclear receptor | pc926 | 2 | 24,83 | 2,00E-05 | 2,40E-03 | NCI-Nature | FAM120B,NR1H2 | 84498,7376 |
Cell adhesion molecules (CAMs) - Homo sapiens (human) | hsa04514 | 2 | 19,70 | 9,00E-05 | 1,35E-02 | KEGG | CLDN2,PVRL2 | 9075,5819 |
Gap junction - Homo sapiens (human) | hsa04540 | 2 | 16,59 | 8,00E-05 | 1,20E-02 | KEGG | GNAI2,PDGFRB | 2771,5159 |
Signaling events mediated by PTP1B | pc948 | 4 | 12,72 | 1,00E-05 | 1,20E-03 | NCI-Nature | CRK,SPRY2,TRPV6,PDGFRB | 1398,10253,55503,5159 |
Retinoic acid receptors-mediated signaling | pc960 | 3 | 10,19 | 2,10E-04 | 2,52E-02 | NCI-Nature | NR1H2,NRIP1,FAM120B | 7376,8204,84498 |
Integrins in angiogenesis | pc989 | 3 | 10,04 | 3,40E-04 | 4,08E-02 | NCI-Nature | CDKN1B,SPP1,VCL | 1027,6696,7414 |
Down-stream signal transduction | pc690 | 2 | 8,28 | 5,00E-05 | 3,14E-02 | Reactome | PDGFRB,NCK2 | 5159,8440 |
Signaling by PDGF | pc876 | 2 | 8,28 | 5,00E-05 | 3,14E-02 | Reactome | PDGFRB,NCK2 | 5159,8440 |
Toll-like receptor signaling pathway - Homo sapiens (human) | hsa04620 | 3 | 7,54 | 3,20E-04 | 4,80E-02 | KEGG | TRAF6,TOLLIP,SPP1 | 7189,54472,6696 |
Homologous recombination - Homo sapiens (human) | hsa03440 | 2 | 7,18 | 1,40E-04 | 2,10E-02 | KEGG | TOP3B,RAD54B | 8940,25788 |
LPA receptor mediated events | pc1042 | 4 | 7,07 | 1,30E-04 | 1,56E-02 | NCI-Nature | BIRC2,TRIP6,TRAF6,CRK | 329,7205,7189,1398 |
Focal adhesion - Homo sapiens (human) | hsa04510 | 8 | 6,55 | 3,00E-05 | 4,50E-03 | KEGG | SPP1,VCL,VASP,CRK,PDGFRB,BIRC2,CCND3,PAK7 | 6696,7414,7408,1398,5159,329,896,57144 |
TCR signaling in naive CD4+ T cells | pc1031 | 4 | 6,54 | 3,00E-04 | 3,60E-02 | NCI-Nature | BIRC2,TRAF6,GRAP2,TRPV6 | 329,7189,9402,55503 |
Axon guidance - Homo sapiens (human) | hsa04360 | 5 | 6,50 | 1,40E-04 | 2,10E-02 | KEGG | GNAI2,PAK7,NTN4,ABLIM1,NCK2 | 2771,57144,59277,3983,8440 |
TCR signaling in naive CD8+ T cells | pc997 | 4 | 6,34 | 3,80E-04 | 4,56E-02 | NCI-Nature | TRAF6,GRAP2,TRPV6,BIRC2 | 7189,9402,55503,329 |
Lysine degradation - Homo sapiens (human) | hsa00310 | 3 | 6,28 | 1,00E-04 | 1,50E-02 | KEGG | OGDH,AASDHPPT,EHMT2 | 4967,60496,10919 |
IGF1 pathway | pc1041 | 3 | 6,26 | 3,60E-04 | 4,32E-02 | NCI-Nature | CRK,NCK2,YWHAE | 1398,8440,7531 |
p75(NTR)-mediated signaling | pc978 | 5 | 6,02 | 2,60E-04 | 3,12E-02 | NCI-Nature | YWHAE,TRAF6,BIRC2,RTN4,LINGO1 | 7531,7189,329,57142,84894 |
Proteogylcan syndecan-mediated signaling events | pc1045 | 5 | 5,53 | 2,20E-04 | 2,64E-02 | NCI-Nature | BSG,HGS,CRK,SPRY2,SPP1 | 682,9146,1398,10253,6696 |
Syndecan-1-mediated signaling events | pc974 | 3 | 5,46 | 1,60E-04 | 1,92E-02 | NCI-Nature | BSG,CRK,HGS | 682,1398,9146 |
Plasma membrane estrogen receptor signaling | pc1048 | 6 | 4,07 | 3,60E-04 | 4,32E-02 | NCI-Nature | CRK,SLC9A1,IRF4,NCK2,YWHAE,TRAF6 | 1398,6548,3662,8440,7531,7189 |