Figure 6

Model for a possible cooperation of Meis2, Pax3, Pax7 and Otx2 during tectal development. See text for details. Red lines indicate negative regulation, green arrows positive regulation. Dashed lines indicate hypothetical direct regulation of the Meis2 promoter/enhancer by different Pax3 concentrations. Solid lines indicate indirect regulation of Meis2 expression via Pax3/7 mediated induction of Fgf8 as previously reported: (1) Regulation of Meis2 expression in response to Ras-MAPK signaling levels reported in [19]; (2) Induction of Fgf8 by Pax3 and Pax7 reported in [11]; (3) Existence of Meis2-Otx2 containing protein complexes in the tectal anlage reported in [17].